Detection of newly antibody‐defined epitopes on HLA class I alleles reacting with antibodies induced during pregnancy

This report describes a HLAMatchmaker‐based analysis of 16 postpregnancy sera tested in single HLA‐ABC allele binding assays. Most sera reacted with alleles carrying epitopes that have been antibody‐verified, and this study focused on the reactivity of additional alleles that share other epitopes corresponding to eplets and other amino acid residue configurations. This analysis led in the identification of 16 newly antibody‐defined epitopes, seven are equivalent to eplets and nine correspond to combinations of eplets in combination with other nearby residue configurations. These epitopes will be added to the repertoire of antibody‐verified epitopes in the HLA Epitope Registry.

Source: International Journal of Immunogenetics - June 15, 2016 Category: Genetics & Stem Cells Authors: R. J. Duquesnoy, G. Hönger, I. Hösli, M. Marrari, S. Schaub Tags: Original Article Source Type: research