Comparative gene expression analysis of the engulfment and cell motility (ELMO) protein family in the mouse brain
Publication date: Available online 12 September 2019Source: Gene Expression PatternsAuthor(s): Yumi Sato, Akira Sato, Shota Mizuno, Jun-na Hirota, Shuhei Fujima, Chiaki Ishii, Yoshitake Sano, Teiichi FuruichiAbstractEngulfment and cell motility (ELMO) proteins bind to Dock180, a guanine nucleotide exchange factor (GEF) of the Rac family, and regulate GEF activity. The resultant ELMO/Dock180/Rac module regulates cytoskeletal reorganization responsible for the engulfment of apoptotic cells, cell migration, and neurite extension. The expression and function of Elmo family proteins in the nervous system, however, are not yet f...
Source: Gene Expression Patterns - September 13, 2019 Category: Genetics & Stem Cells Source Type: research
Spatiotemporal expression profile of embryonic and adult ankyrin repeat and EF-hand domain containing protein 1-encoding genes ankef1a and ankef1b in zebrafish
Publication date: Available online 12 September 2019Source: Gene Expression PatternsAuthor(s): Jeffrey G. Daniel, Jennifer R. PanizziAbstractRecent human next-generation sequencing (NGS) studies indicate a correlation between ANKEF1 (ankyrin repeat and EF-hand domain containing protein 1) expression and cilia formation or function. Additionally, a single study conducted in the African clawed frog (Xenopus laevis) showed ankef1 is down-regulated after pharmacological fibroblast growth factor (FGF) inhibition and plays a role in protocadherin-mediated cell protrusion and adhesion. That study also revealed a critical role for...
Source: Gene Expression Patterns - September 12, 2019 Category: Genetics & Stem Cells Source Type: research
Editorial Board
Publication date: September 2019Source: Gene Expression Patterns, Volume 33Author(s): (Source: Gene Expression Patterns)
Source: Gene Expression Patterns - August 24, 2019 Category: Genetics & Stem Cells Source Type: research
Expression of transcription factors and signaling molecules in the cerebellar granule cell development
This study provides a basis for future studies on the cerebellar GC development and medulloblastoma. (Source: Gene Expression Patterns)
Source: Gene Expression Patterns - August 20, 2019 Category: Genetics & Stem Cells Source Type: research
Expression of Lhx6 in the adult and developing mouse retina
ConclusionLhx6 was expressed in RGCs and ACs in both the adult and developing mouse retina. (Source: Gene Expression Patterns)
Source: Gene Expression Patterns - July 31, 2019 Category: Genetics & Stem Cells Source Type: research
Early expression of Tubulin Beta-III in avian cranial neural crest cells
Publication date: Available online 29 July 2019Source: Gene Expression PatternsAuthor(s): Jose Chacon, Crystal D. RogersAbstractNeural crest cells are a transient stem-like cell population that forms in the dorsal neural tube of vertebrate embryos and then migrates to various locations to differentiate into diverse derivatives such as craniofacial bone, cartilage, and the enteric and peripheral nervous systems. The current dogma of neural crest cell development suggests that there is a specific hierarchical gene regulatory network (GRN) that controls the induction, specification, and differentiation of these cells at speci...
Source: Gene Expression Patterns - July 31, 2019 Category: Genetics & Stem Cells Source Type: research
Spatial analysis of RECK, MT1-MMP, and TIMP-2 proteins during early Xenopus laevis development
Publication date: Available online 26 July 2019Source: Gene Expression PatternsAuthor(s): Jessica A. Willson, Sashko DamjanovskiAbstractProper cell-cell and cell-ECM interactions are vital for cell migration and patterning of the vertebrate embryo. MMPs and their inhibitors, RECK and TIMPs, are all differentially expressed during embryogenesis to regulate such ECM remodeling and cell interactions. MT1-MMP, RECK, and TIMP-2 are unique amongst other ECM-regulating proteins as they act in the pericellular space. Past studies have shown that RECK and TIMP-2 interact with MT1-MMP on the cell surface, thereby influencing cell be...
Source: Gene Expression Patterns - July 27, 2019 Category: Genetics & Stem Cells Source Type: research
Hectd1 is essential for embryogenesis in mice
Publication date: Available online 10 July 2019Source: Gene Expression PatternsAuthor(s): Donato D'Alonzo, Fabienne Hélène Emch, Xiaoli Shen, Elisabeth Bruder, Christian De Geyter, Hong ZhangAbstractMany aspects of the functional role of the E3 ubiquitin ligase Hectd1 in embryogenesis and in cell biology still remain to be elucidated. In order to contribute to this task we now report the generation of a new transgenic mouse model for Hectd1 using the gene trap strategy. The HECT domain deletion mutant mouse was created by inserting a β-geo cassette into the Hectd1 locus. Mice homozygous for Hectd1-mutant showed early em...
Source: Gene Expression Patterns - July 10, 2019 Category: Genetics & Stem Cells Source Type: research
Genome imprinting in stem cells: A mini-review
Publication date: Available online 4 July 2019Source: Gene Expression PatternsAuthor(s): Rasoul Godini, Keyvan Karami, Hossein FallahiAbstractGenomic imprinting is an epigenetic process result in silencing of one of the two alleles (maternal or paternal) based on the parent of origin. Dysregulation of imprinted genes results in detectable developmental and differential abnormalities. Epigenetics erasure is required for resetting the cell identity to a ground state during the production of induced pluripotent stem (iPS) cells from somatic cells. There are some contradictory reports regarding the status of the imprinting mar...
Source: Gene Expression Patterns - July 5, 2019 Category: Genetics & Stem Cells Source Type: research
Expression pattern of Kmt2d in murine craniofacial tissues
Publication date: Available online 19 June 2019Source: Gene Expression PatternsAuthor(s): Chunmin Dong, Meenakshi Umar, Garrett Bartoletti, Apurva Gahankari, Lauren Fidelak, Fenglei HeAbstractFormation of the calvaria is a multi-staged process and is regulated by multiple genetic factors. Disruption of normal calvarial development usually causes craniosynostosis, a prevalent birth defect characterized by premature fusion of calvarial bone. Recent studies have identified mutations of KMT2D allele in patients with craniosynostosis, indicating a potential role for Kmt2d in calvarial development. KMT2D mutations have also been...
Source: Gene Expression Patterns - June 21, 2019 Category: Genetics & Stem Cells Source Type: research
Primary cilia in murine palatal rugae development
Publication date: Available online 19 June 2019Source: Gene Expression PatternsAuthor(s): Mayuko Nakaniwa, Maiko Kawasaki, Katsushige Kawasaki, Akane Yamada, Fumiya Meguro, Maeda Takeyasu, Atsushi OhazamaAbstractPeriodic patterning of iterative structures is a fundamental process during embryonic development, since these structures are diverse across the animal kingdom. Therefore, elucidating the molecular mechanisms in the formation of these structures promotes understanding of the process of organogenesis. Periodically patterned ridges, palatal rugae (situated on the hard palate of mammals), are an excellent experimental...
Source: Gene Expression Patterns - June 19, 2019 Category: Genetics & Stem Cells Source Type: research
Analysis of the novel excretory cell expressed ECP-1 protein and its proposed ECP-1/IFC-2 fusion protein EXC-2 in the nematode Caenorhabditis elegans
Publication date: Available online 15 June 2019Source: Gene Expression PatternsAuthor(s): Anton Karabinos, Ekkehard Schulze, Ralf BaumeisterAbstractThe multigene family of cytoplasmic intermediate filament (IF) proteins in C. elegans covers eleven members, of which four (IFA-1 to IFA-3, IFB-1), which form an obligate heteropolymeric IF system, are essential for development. The six other C. elegans IF proteins IFB-2, IFC-1, IFC-2, IFD-1, IFD-2 and IFP-1 are co-expressed in the intestinal terminal web during different developmental stages, reveal various differently penetrant RNAi phenotypes and form another heteropolymeric...
Source: Gene Expression Patterns - June 15, 2019 Category: Genetics & Stem Cells Source Type: research
Expression pattern of ABCDE model genes in floral organs of bolting garlic clone
Publication date: Available online 13 June 2019Source: Gene Expression PatternsAuthor(s): Fahimeh Ghaemizadeh, Farshad Dashti, Alireza ShafeiniaAbstractA correct understanding of the ABCDE model genes expression, especially genes involved in the development of the reproductive floral organs, in bolting and fertile garlic clones improves the process of its fertilization and breeding programs. Therefore, Real-Time PCR was employed to evaluate the temporal and spatial expression patterns of some floral organ identity genes in the inflorescence and different floret organs in the two stages of green and purple florets of boltin...
Source: Gene Expression Patterns - June 13, 2019 Category: Genetics & Stem Cells Source Type: research
Evaluation and validation of experimental condition-specific reference genes for normalization of gene expression in Asia II-I Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae)
Publication date: Available online 8 June 2019Source: Gene Expression PatternsAuthor(s): Ramandeep Kaur, Mridula Gupta, Satnam Singh, Suneet PandherAbstractFunctional genomics in whitefly, Bemisia tabaci is gaining impetus due to its polyphagous nature, worldwide distribution and recently sequenced whole genome. These studies require an in-depth evaluation and validation of reference genes in different development stages and variable experimental setups. Normalization with reference genes is an essential step in the gene expression studies. Rather than selecting a reference gene empirically, the suitability of these genes ...
Source: Gene Expression Patterns - June 9, 2019 Category: Genetics & Stem Cells Source Type: research
Expression of the guanine nucleotide exchange factor, RAPGEF5, during mouse and human embryogenesis
Publication date: Available online 1 June 2019Source: Gene Expression PatternsAuthor(s): Reham Alharatani, John N. Griffin, Karen J. LiuAbstractRap GTPases mediate fundamental cellular processes, including cell adhesion, migration and intracellular signal transduction. The subcellular activity of these GTPases is regulated by dedicated activators (guanine nucleotide exchange factors, GEFs) and deactivators (GTPase-activating proteins, GAPs). RAPGEF5 is a potent activator of Rap proteins and mutations in RAPGEF5 have been linked to both neurological disorders and congenital heart disease. In the frog model, Xenopus tropical...
Source: Gene Expression Patterns - June 1, 2019 Category: Genetics & Stem Cells Source Type: research
