JMJ24 antagonizes histone H3K9 demethylase IBM1/JMJ25 function and interacts with RNAi pathways for gene silencing
Publication date: November 2017 Source:Gene Expression Patterns, Volumes 25–26 Author(s): Laure Audonnet, Yuan Shen, Dao-Xiu Zhou Dimethylation of histone H3 lysine 9 (H3K9me2) is a heterochromatic mark linked to DNA methylation and gene repression. Removal of H3K9me2 from gene bodies by the jmjC histone demethylase IBM1/JMJ25 inhibits DNA methylation and derepresses gene expression. In this work, we analyzed the function of a closely related homolog of IBM1/JMJ25, namely JMJ24. We show that jmj24 mutations produced a number of subtle developmental defects, while affecting only a relatively small number of genes at ...
Source: Gene Expression Patterns - May 24, 2017 Category: Genetics & Stem Cells Source Type: research
Expression patterns of prune2 is regulated by Notch and retinoic acid signaling pathways in the zebrafish embryogenesis
Publication date: Available online 11 March 2017 Source:Gene Expression Patterns Author(s): Mrudhula Anuppalle, Sateesh Maddirevula, Ajeet Kumar, Tae-Lin Huh, Joonho Choe, Myungchull Rhee PRUNE2 has been identified as a susceptible gene for Alzheimer's disease and a marker for leiomyosarcomas. Isoforms of Prune2 regulate neuronal cell differentiation and synaptogenesis. Although expression pattern of Prune2 has been reported in the murine brain, its expression patterns and regulation along vertebrate embryogenesis remain to be further investigated. We thus defined the expression profiles and transcriptional regulat...
Source: Gene Expression Patterns - March 10, 2017 Category: Genetics & Stem Cells Source Type: research
Temporal profiling of photoreceptor lineage gene expression during murine retinal development
Publication date: Available online 10 March 2017 Source:Gene Expression Patterns Author(s): Tooka Aavani, Nobuhiko Tachibana, Valerie Wallace, Jeffrey Biernaskie, Carol Schuurmans Rod and cone photoreceptors are photosensitive cells in the retina that convert light to electrical signals that are transmitted to visual processing centres in the brain. During development, cones and rods are generated from a common pool of multipotent retinal progenitor cells (RPCs) that also give rise to other retinal cell types. Cones and rods differentiate in two distinct waves, peaking in mid-embryogenesis and the early postnatal pe...
Source: Gene Expression Patterns - March 9, 2017 Category: Genetics & Stem Cells Source Type: research
Characterization of arteriovenous identity in the developing neonate mouse retina
In this study, we describe the expression of previously established AV markers and assess arteriovenous acquisition and identity in the murine neonatal retina. Using in situ hybridization and immunofluorescent antibody staining techniques, we analyzed numerous AV differentiation markers such as EphB4-EphrinB2 and members of the Notch pathway. We find that at postnatal day 3 (P3), when blood vessels are beginning to populate the retina, AV identity is not immediately established. However, by P5 expression of many molecular identifiers of arteries and veins become restricted to their respective vessel types. This molecular d...
Source: Gene Expression Patterns - February 2, 2017 Category: Genetics & Stem Cells Source Type: research
A visual screen for diet-regulated proteins in the Drosophila ovary using GFP protein trap lines
Publication date: Available online 16 January 2017 Source:Gene Expression Patterns Author(s): Hwei-Jan Hsu, Daniela Drummond-Barbosa The effect of diet on reproduction is well documented in a large number of organisms; however, much remains to be learned about the molecular mechanisms underlying this connection. The Drosophila ovary has a well described, fast and largely reversible response to diet. Ovarian stem cells and their progeny proliferate and grow faster on a yeast-rich diet than on a yeast-free (poor) diet, and death of early germline cysts, degeneration of early vitellogenic follicles and partial block in ov...
Source: Gene Expression Patterns - January 15, 2017 Category: Genetics & Stem Cells Source Type: research
Temporal and spatial expression pattern of Nnat during mouse eye development
Conclusions The expression pattern suggests that Nnat may play an important role during eye development and in the maintenance of mature eye. (Source: Gene Expression Patterns)
Source: Gene Expression Patterns - December 27, 2016 Category: Genetics & Stem Cells Source Type: research
Expression profile of rrbp1 genes during embryonic development and in adult tissues of Xenopus laevis
This study reports Xenopus rrbp1 expression during early embryonic development and in adult tissues. Our study will facilitate the functional analysis of Rrbp1 family during embryonic development. (Source: Gene Expression Patterns)
Source: Gene Expression Patterns - December 25, 2016 Category: Genetics & Stem Cells Source Type: research
The expression patterns of Tetratricopeptide repeat domain 36 (Ttc36)
Publication date: Available online 5 November 2016 Source:Gene Expression Patterns Author(s): Yuru Zhou, Ya Zhao, Xiaoyan Lv, Yunhong Liu, Zhaomin Mao, Qingling He, Zhongshi Lyu, Dongsheng Ni, Yaoshui Long, Pan Ju, Jianing Liu, Yuping Gu, Qin Zhou Tetratricopeptide repeat domain 36 (Ttc36), whose coding protein belongs to tetratricopeptide repeat (TPR) motif family, has not been studied extensively. We for the first time showed that Ttc36 is evolutionarily conserved across mammals by bioinformatics. Rabbit anti-mouse Ttc36 polyclonal antibody was generated by injecting synthetic full-length peptides through ...
Source: Gene Expression Patterns - November 5, 2016 Category: Genetics & Stem Cells Source Type: research
Developmental expression of mGlu2 and mGlu3 in the mouse brain
Publication date: Available online 4 November 2016 Source:Gene Expression Patterns Author(s): Caitlin E. McOmish, Elena Y. Demireva, Jay A. Gingrich The glutamatergic system directs central nervous system (CNS) neuronal activity and may underlie various neuropsychiatric disorders. Glutamate transmits its effects through multiple receptor classes. Class II metabotropic glutamate receptors, mGlu2 and mGlu3, play an important role in regulating synaptic release of different neurotransmitter systems and consequently modulate signaling across several neuronal subtypes. Drugs targeting mGlu2 and mGlu3 are seen as potential ...
Source: Gene Expression Patterns - November 4, 2016 Category: Genetics & Stem Cells Source Type: research
Expression of the insulinoma-associated 1 (insm1) gene in Xenopus laevis tadpole retina and brain
We report the detailed expression pattern of insm1 in the X. laevis tadpole retina and brain. X. laevis insm1 is expressed in most of the ciliary marginal zone of the mature retina and the optic tectum, dorsal pallium, hypothalamus and preoptic areas of the developing tadpole brain. Overall, insm1 is expressed in regions of the tadpole brain and retina harboring populations of progenitor cells. (Source: Gene Expression Patterns)
Source: Gene Expression Patterns - September 23, 2016 Category: Genetics & Stem Cells Source Type: research
Gene expression analysis during the induction and patterning of the conjunctival papillae in the chick embryonic eye
This study also outlines the similarities between the conjunctival papillae and other placodes and may provide insights into the evolution and development of the conjunctival papillae. (Source: Gene Expression Patterns)
Source: Gene Expression Patterns - September 20, 2016 Category: Genetics & Stem Cells Source Type: research
Embryonic expression patterns of Hox genes in the oligochaete annelid Tubifex tubifex
Publication date: Available online 6 September 2016 Source:Gene Expression Patterns Author(s): Mao Endo, Chiharu Sakai, Takashi Shimizu We have cloned and characterized the expression of seven Hox genes (designated Ttu-lab, Ttu-Dfd, Ttu-Scr1, Ttu-Scr2, Ttu-Lox5, Ttu-Lox4 and Ttu-Lox2) from the oligochaete annelid Tubifex tubifex. RT-PCR analyses show that except for Ttu-Lox4 and Ttu-Lox2 which begin expression as early as cleavage stages, Tubifex Hox genes are expressed during stages 13–18 when embryos undergo germ band formation, segmentation and body elongation. In terms of combination of tissues (or organs) exhib...
Source: Gene Expression Patterns - September 6, 2016 Category: Genetics & Stem Cells Source Type: research
Expression profiles of the G α subunits during Xenopus tropicalis embryonic development
Publication date: Available online 7 September 2016 Source:Gene Expression Patterns Author(s): Jaime Fuentealba, Gabriela Toro-Tapia, Marion Rodriguez, Cecilia Arriagada, Alejandro Maureira, Andrea Beyer, Soraya Villaseca, Juan I. Leal, Maria V. Hinrichs, Juan Olate, Teresa Caprile, Marcela Torrejón Heterotrimeric G protein signaling plays major roles during different cellular events. However, there is a limited understanding of the molecular mechanisms underlying G protein control during embryogenesis. G proteins are highly conserved and can be grouped into four subfamilies according to sequence homology an...
Source: Gene Expression Patterns - September 6, 2016 Category: Genetics & Stem Cells Source Type: research
Development of the cardiac conduction system in zebrafish
Publication date: Available online 1 September 2016 Source:Gene Expression Patterns Author(s): Kar-Lai Poon, Michael Liebling, Igor Kondrychyn, Thomas Brand, Vladimir Korzh The cardiac conduction system (CCS) propagates and coordinates the electrical excitation that originates from the pacemaker cells, throughout the heart, resulting in rhythmic heartbeat. Its defects result in life-threatening arrhythmias and sudden cardiac death. Understanding of the factors involved in the formation and function of the CCS remains incomplete. By transposon assisted transgenesis, we have developed enhancer trap (ET) lines of zebra...
Source: Gene Expression Patterns - September 1, 2016 Category: Genetics & Stem Cells Source Type: research
Differential gene expression patterns and colocalization of ATP-gated P2X6/P2X4 ion channels during rat small intestine ontogeny
Publication date: Available online 19 August 2016 Source:Gene Expression Patterns Author(s): Karla Padilla, David Gonzalez-Mendoza, Laura C. Berumen, Jesica E. Escobar, Ricardo Miledi, Guadulupe García-Alcocer Gene coding for ATP-gated receptor ion channels (P2X1–7) has been associated with the developmental process in various tissues; among these ion channel subtypes, P2X6 acts as a physiological regulator of P2X4 receptor functions when the two receptors form heteroreceptors. The P2X4 receptor is involved in pain sensation, the inflammatory process, and body homeostasis by means of Mg(2+) absorption through th...
Source: Gene Expression Patterns - August 19, 2016 Category: Genetics & Stem Cells Source Type: research
