Mechanism of programmed cell death factor 4/nuclear factor-{kappa}B signaling pathway in porcine coronary micro-embolization-induced cardiac dysfunction
In conclusion, PDCD4/NF-B signaling pathway activation is an important mechanism for CME-induced cardiac dysfunction, suggesting that inhibition of PDCD4/NF-B signaling pathway may be a potential target for the prevention and treatment of CME. (Source: Experimental Biology and Medicine)
Source: Experimental Biology and Medicine - October 30, 2015 Category: Research Authors: Su, Q., Li, L., Wang, J., Zhou, Y., Liu, Y. Tags: Biochemistry & amp;amp; Molecular Biology Source Type: research
Curcumin sensitizes human lung cancer cells to apoptosis and metastasis synergistically combined with carboplatin
Although carboplatin is one of the standard chemotherapeutic agents for non-small cell lung cancer (NSCLC), it has limited therapeutic efficacy due to activation of a survival signaling pathway and the induction of multidrug resistance. Curcumin, a natural compound isolated from the plant Curcuma longa, is known to sensitize tumors to different chemotherapeutic agents. The aim of this study is to evaluate whether curcumin can chemosensitize lung cancer cells to carboplatin and to analyze the signaling pathway underlying this synergism. We investigated the synergistic effect of both agents on cell proliferation, apoptosis, ...
Source: Experimental Biology and Medicine - October 30, 2015 Category: Research Authors: Kang, J. H., Kang, H. S., Kim, I. K., Lee, H. Y., Ha, J. H., Yeo, C. D., Kang, H. H., Moon, H. S., Lee, S. H. Tags: Biochemistry & amp;amp; Molecular Biology Source Type: research
The effect of physical training on the N-methyl-N-nitrosourea-induced mammary carcinogenesis of Sprague-Dawley rats
The impact of physical activity on carcinogenesis has been demonstrated in many studies. Taking into account the discrepant results of physical exercise on the cell proliferation and apoptosis of breast cancer, we aimed to examine the impact of physical training on N-methyl-N-nitrosourea-(MNU)-induced mammary carcinogenesis. Fifty female rats were divided into four groups according to the intensity of physical activity they undertook. The number of developed tumors, tumor volume, and histopathological diagnoses were noted. Apoptosis and cell proliferation were studied by the number of TUNEL-positive and Ki-67-expressing ce...
Source: Experimental Biology and Medicine - October 30, 2015 Category: Research Authors: Malicka, I., Siewierska, K., Pula, B., Kobierzycki, C., Haus, D., Paslawska, U., Cegielski, M., Dziegiel, P., Podhorska-Okolow, M., Wozniewski, M. Tags: Anatomy & amp;amp; Pathology Source Type: research
Influence of renovascular hypertension on the distribution of vasoactive intestinal peptide in the stomach and heart of rats
Arterial hypertension is associated with serious dysfunction of the cardiovascular system and digestive system. Given the relevant role of vasoactive intestinal peptide (VIP) in the regulation of digestion process, control of blood pressure and heart rate as well as cardio- and gastro-protective character of the peptide, it appeared worthwhile to undertake the research aimed at immunohistochemical identification and evaluation of VIP-positive structures in the pylorus and heart of hypertensive rats. Up to now, this issue has not been investigated. The experimental model of hypertension in rats according to Goldblatt (two-k...
Source: Experimental Biology and Medicine - October 30, 2015 Category: Research Authors: Kasacka, I., Piotrowska, Z., Janiuk, I. Tags: Anatomy & amp;amp; Pathology Source Type: research
Recent discoveries concerning the involvement of transcription factors from the Grainyhead-like family in cancer
The Grainyhead-like (GRHL) family of transcription factors has three mammalian members, which are currently termed Grainyhead-like 1 (GRHL1), Grainyhead-like 2 (GRHL2), and Grainyhead-like 3 (GRHL3). These factors adopt a DNA-binding immunoglobulin fold homologous to the DNA-binding domain of key tumor suppressor p53. Their patterns of expression are tissue and developmentally specific. Earlier studies of the GRHL proteins focused on their functions in mammalian development. In recent years, these factors have been linked to many different types of cancer: squamous cell carcinoma of the skin, breast cancer, gastric cancer,...
Source: Experimental Biology and Medicine - October 30, 2015 Category: Research Authors: Mlacki, M., Kikulska, A., Krzywinska, E., Pawlak, M., Wilanowski, T. Tags: Minireviews Source Type: research
