Corrigendum to “The untold story of IFN-γ in cancer biology” [Cytokine Growth Factor Rev. 31 (2016) 73–81]
Since the publication of this article, the authors and Editor have noticed an error in the article type, as listed on PubMed. The correct article type is Review. The html and online versions have been amended. The authors apologize for any inconvenience caused. (Source: Cytokine and Growth Factor Reviews)
Source: Cytokine and Growth Factor Reviews - February 27, 2017 Category: Molecular Biology Authors: M. Alper Kursunel, Gunes Esendagli Tags: Corrigendum Source Type: research
Role of NOD- like Receptors in Glioma Angiogenesis: Insights into future therapeutic interventions
Gliomas are the most prevalent solid tumors accounting for 46 –70% of all central nervous system (CNS) tumors [1]. There are more than 100 histologically distinct types of primary brain and CNS tumors. Nearly 78,000 new cases of primary brain tumors are expected to be diagnosed this year [2]. This figure includes nearly 25,000 primary malignant and 53,000 no n-malignant brain tumors [2]. There are nearly 700,000 people in the U.S. living with a primary CNS tumor [2]. These tumors can be composed of either heterogeneous or homogenous population of cells such as microglia, astrocytes and oligodendrocytes. (Source: Cytokine...
Source: Cytokine and Growth Factor Reviews - February 9, 2017 Category: Molecular Biology Authors: Shivanjali Saxena, Sushmita Jha Tags: Survey Source Type: research
Crosstalk between insulin-like growth factor (IGF) receptor and integrins through direct integrin binding to IGF1
Insulin-like growth factor-1 (IGF1) is a polypeptide hormone that is homologous to proinsulin. Most of (80%) of the IGF1 in serum is synthesized by the liver and secreted, and it functions as an endocrine hormone. The remaining 20% of the IGF1 is synthesized in the periphery. Usually, connective tissue cell types, such as stromal cells, and IGF1 that is synthesized in the periphery can function to regulate cell survival by autocrine and paracrine mechanisms [1]. IGF1 is also secreted by many cancer cells at abnormally high levels. (Source: Cytokine and Growth Factor Reviews)
Source: Cytokine and Growth Factor Reviews - February 1, 2017 Category: Molecular Biology Authors: Yoshikazu Takada, Yoko K. Takada, Masaaki Fujita Tags: Mini review Source Type: research
Editorial Board and Publication information
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Source: Cytokine and Growth Factor Reviews - January 31, 2017 Category: Molecular Biology Source Type: research
Effects of adipokines and obesity on uterine contractility
The prevalence of obesity, as defined by a body mass index (BMI)>30kg/m2, has sharply increased in developed countries and the World Health Organization (WHO) considers it is a significant health threat, particularly because of its association with cardiovascular disease. It represents a new challenge for healthcare professionals because it alters patients ’ classical management. (Source: Cytokine and Growth Factor Reviews)
Source: Cytokine and Growth Factor Reviews - January 13, 2017 Category: Molecular Biology Authors: Henri Aza ïs, Audrey Leroy, Louise Ghesquiere, Philippe Deruelle, Sandy Hanssens Tags: Mini review Source Type: research
Bone morphogenetic protein-2 and tumor growth: diverse effects and possibilities for therapy
Currently, all clinical situations in which recombinant human bone morphogenetic protein-2 (rhBMP-2) is employed are orthopaedic in nature. As is evident from the name, “BMP-2”, this material induces a recapitulation of endochondral bone formation when appropriate undifferentiated cells are exposed to it. It should not be forgotten, however, that BMPs, including BMP-2, are found in many tissues and perform physiological functions that have nothing to do with bo ne formation or skeletal physiology whatsoever [1]. (Source: Cytokine and Growth Factor Reviews)
Source: Cytokine and Growth Factor Reviews - January 13, 2017 Category: Molecular Biology Authors: Haijun Tian, Jie Zhao, Elsa J. Brochmann, Jeffrey C. Wang, Samuel S. Murray Tags: Survey Source Type: research
Expression and signaling of NGF in the healthy and injured retina
The nerve growth factor (NGF) is a polypeptide member of the small family of evolutionarily well-conserved neurotrophins which also includes brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT3), and NT4/5 [1]. Mature NGF is derived from its precursor form proNGF after proteolytic cleavage within the extracellular space [2] where it activates two distinct cell surface receptors. The receptor tyrosine kinase A (TrkA) is selective to NGF binding and can trigger different signaling pathways related to cell survival, proliferation and differentiation [3,4], while the p75 neurotrophin receptor (p75NTR) binds non-specif...
Source: Cytokine and Growth Factor Reviews - December 1, 2016 Category: Molecular Biology Authors: Tarcyane Barata Garcia, Margrit Hollborn, Andreas Bringmann Tags: Survey Source Type: research
Expression and signaling of NGF in the healthy and injured rodent retina
The nerve growth factor (NGF) is a polypeptide member of the small family of evolutionarily well-conserved neurotrophins which also includes brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT3), and NT4/5 [1]. Mature NGF is derived from its precursor form proNGF after proteolytic cleavage within the extracellular space [2] where it activates two distinct cell surface receptors. The receptor tyrosine kinase A (TrkA) is selective to NGF binding and can trigger different signaling pathways related to cell survival, proliferation and differentiation [3,4], while the p75 neurotrophin receptor (p75NTR) binds non-specif...
Source: Cytokine and Growth Factor Reviews - December 1, 2016 Category: Molecular Biology Authors: Tarcyane Barata Garcia, Margrit Hollborn, Andreas Bringmann Tags: Survey Source Type: research
Post-transcriptional regulation of cytokine and growth factor signaling in cancer
In addition to regulating cell proliferation, differentiation, and apoptosis, cytokines and growth factors also play important roles in coordinating growth signal responses during development. The ability of cytokines to affect cellular self-renewal capacity, migration, senescence, or apoptosis is often impaired in cancer. PubMed citations include approximately 7000 publications related to abnormal cytokine and growth factor signaling in cancer. Researchers have shown altered levels of expression or function of numerous cytokines, including growth factors and chemokines in malignant tissues relative to healthy tissues (rev...
Source: Cytokine and Growth Factor Reviews - December 1, 2016 Category: Molecular Biology Authors: Irina Vlasova-St. Louis, Paul R. Bohjanen Tags: Survey Source Type: research
Role of neurotrophic factors in attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder (ADHD) is characterized by inattention, impulsivity, and hyperactivity, and is highly prevalent in children worldwide. The etiology of ADHD has not been clearly identified, although evidence supports neurobiological and genetic origins [1]. ADHD is frequently comorbid with a variety of psychiatric disorders, including oppositional defiant disorder, conduct disorder, affective disorder, and tic disorders [2]. The impact of ADHD on individuals and families is great, involving financial costs, stress to families, and adverse academic and vocational outcomes [1]. (Source: Cytokine and G...
Source: Cytokine and Growth Factor Reviews - November 29, 2016 Category: Molecular Biology Authors: Shih-Jen Tsai Tags: Mini review Source Type: research
Editorial Board and Publication information
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Source: Cytokine and Growth Factor Reviews - November 24, 2016 Category: Molecular Biology Source Type: research
Cytokine signatures in hereditary fever syndromes (HFS)
Autoinflammatory disorders (AIDs) are a group of inherited diseases characterized by unprovoked episodes of systemic inflammation. These disorders differ from autoimmune diseases as their pathogenesis is not mediated by self-reactive antibodies or T lymphocytes [1]. Another distinction between these two groups of disorders is the primary role of the innate immune system in mediating autoinflammatory diseases, versus the recognized importance of the adaptive immune system in autoimmune disorders [2]. (Source: Cytokine and Growth Factor Reviews)
Source: Cytokine and Growth Factor Reviews - November 21, 2016 Category: Molecular Biology Authors: Jos é Noel Ibrahim, Isabelle Jéru, Jean-Claude Lecron, Myrna Medlej-Hashim Source Type: research
DNA damage talks to inflammation
Interleukin-1 alpha (IL-1 α) and Interleukin-1 beta (IL-1β) are classical cytokines that are mostly known for their extracellular activity following their binding the IL-1 receptor (IL-1R), and for their biological role as pro-inflammatory agents. Despite the fact that both proteins have been intensively studied, the funda mental differences between the two molecules and their effects on non-conventional inflammatory processes, aside from their role in acute inflammation, are often disregarded. For instance, the two IL-1 proteins (solely or synergistically) were shown to play distinct roles in numerous physiological p ro...
Source: Cytokine and Growth Factor Reviews - November 17, 2016 Category: Molecular Biology Authors: Idan Cohen Tags: Mini review Source Type: research
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Source: Cytokine and Growth Factor Reviews - October 27, 2016 Category: Molecular Biology Authors: Hans Bluyssen Tags: Letter to the Editor Source Type: research
Myokines and adipokines: Involvement in the crosstalk between skeletal muscle and adipose tissue
Skeletal muscle-derived factors “myokines” and adipose tissue-derived factors “adipokines” exert their effects mainly in the organs of adipose tissue and/or skeletal muscle to form the muscle-adipose axis that regulates body composition. (Source: Cytokine and Growth Factor Reviews)
Source: Cytokine and Growth Factor Reviews - October 12, 2016 Category: Molecular Biology Authors: Fengna Li, Yinghui Li, Yehui Duan, Chien-An A. Hu, Yulong Tang, Yulong Yin Source Type: research
