Bone morphogenetic protein-2 and tumor growth: diverse effects and possibilities for therapy

Currently, all clinical situations in which recombinant human bone morphogenetic protein-2 (rhBMP-2) is employed are orthopaedic in nature. As is evident from the name, “BMP-2”, this material induces a recapitulation of endochondral bone formation when appropriate undifferentiated cells are exposed to it. It should not be forgotten, however, that BMPs, including BMP-2, are found in many tissues and perform physiological functions that have nothing to do with bo ne formation or skeletal physiology whatsoever [1].
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Tags: Survey Source Type: research