Endocytic regulation of cytokine receptor signaling
Endocytosis is coupled to regulation of signaling initiated by plasma membrane receptors. Initially, internalization of the activated receptors was considered only as a means for signal attenuation, but now it is clear that endocytosis also regulates the duration of receptor signaling as well as specificity of signaling outputs (reviewed in Barbieri et al. [1]). Endosomes can serve as mobile signaling platforms facilitating formation of multiprotein signaling assemblies and therefore enabling efficient signal transduction in space and time. (Source: Cytokine and Growth Factor Reviews)
Source: Cytokine and Growth Factor Reviews - July 14, 2016 Category: Molecular Biology Authors: Jaroslaw Cendrowski, Agnieszka Mami ńska, Marta Miaczynska Tags: Mini review Source Type: research
Role of interleukin-18 in the pathophysiology of allergic diseases
Interleukin (IL)-18, discovered only 20 years ago, was first known as interferon (IFN)- γ inducing factor due to its ability to induce Type 1 helper T (Th1) cells to release IFN-γ [1]. Since then, this novel cytokine has been found to be expressed by macrophages, dendritic cells (DCs), epithelial cells, and keratinocytes and to activate a wide variety of lymphoid- and myeloid-derived cell types [2–4]. Induced IL-18 is now identified in a number of disorders, like autoimmunity, atopic and allergen-induced allergic responses, and defense against pathogens, most notably helminths. (Source: Cytokine and Growth Factor Reviews)
Source: Cytokine and Growth Factor Reviews - July 13, 2016 Category: Molecular Biology Authors: Nathan L. Sanders, Anil Mishra Source Type: research
Role of interleukin-18 in the pathophysiology of allergic diseases
Interleukin (IL)-18, discovered only 20 years ago, was first known as interferon (IFN)-γ inducing factor due to its ability to induce Type 1 helper T (Th1) cells to release IFN-γ [1]. Since then, this novel cytokine has been found to be expressed by macrophages, dendritic cells (DCs), epithelial cells, and keratinocytes and to activate a wide variety of lymphoid- and myeloid-derived cell types [2–4]. Induced IL-18 is now identified in a number of disorders, like autoimmunity, atopic and allergen-induced allergic responses, and defense against pathogens, most notably helminths. (Source: Cytokine and Growth Factor Reviews)
Source: Cytokine and Growth Factor Reviews - July 13, 2016 Category: Molecular Biology Authors: Nathan L. Sanders, Anil Mishra Source Type: research
WFIKKN1 and WFIKKN2: “Companion” proteins regulating TGFB activity
WFIKKN1 and WFIKKN2 (also called Growth and differentiation factor Associated Serum Protein (GASP) 2 and 1, respectively) are secreted proteins originally discovered in 2000 and 2002 by Trexler et al. [1,2]. Due to their predicted protein domain composition and their ubiquitous expression, these proteins are assumed to form a family of multivalent protease inhibitors. In 2003, a major advance in the understanding of the function of this gene family was made when WFIKKN2 was described as an MSTN associated protein found in human and mouse sera that could specifically inhibit MSTN, but not activin activity [3]. (Source: Cyto...
Source: Cytokine and Growth Factor Reviews - June 9, 2016 Category: Molecular Biology Authors: Olivier Monestier, V éronique Blanquet Tags: Survey Source Type: research
Interleukin 15: A key cytokine for immunotherapy
Interleukin (IL)-15 is a γc cytokine, produced by various cells in the body [1]. It is a multifunctional cytokine that targets many cell types and connects the innate with the adaptive immune system [1]. It is a member of the 4-α-helical bundle family of cytokines, with 14–15kDa molecular weight and 114 amino acids [2]. Its widespread expression and the ability to influence both immune and non-immune systems of the vertebrates warrants tight regulation [3]. It critically modulates the host defense against intracellular pathogens [3]. (Source: Cytokine and Growth Factor Reviews)
Source: Cytokine and Growth Factor Reviews - June 6, 2016 Category: Molecular Biology Authors: Manoj Patidar, Naveen Yadav, Sarat K. Dalai Tags: Survey Source Type: research
Interleukin 15: A key cytokine for immunotherapy
Interleukin (IL)-15 is a γc cytokine, produced by various cells in the body [1]. It is a multifunctional cytokine that targets many cell types and connects the innate with the adaptive immune system [1]. It is a member of the 4-α-helical bundle family of cytokines, with 14–15kDa molecular weight and 114 amino acids [2]. Its widespread expression and the ability to influence both immune and non-immune systems of the vertebrates warrants tight regulation [3]. It critically modulates the host defense against intracellular pathogens [3]. (Source: Cytokine and Growth Factor Reviews)
Source: Cytokine and Growth Factor Reviews - June 6, 2016 Category: Molecular Biology Authors: Manoj Patidar, Naveen Yadav, Sarat K. Dalai Tags: Survey Source Type: research
A panoramic review and in silico analysis of IL-11 structure and function
Interleukin (IL)-11 is a multifunctional cytokine that was discovered almost 25 years ago. IL-11 has megakaryocytopoiesis activity, which led to its clinical indication for thrombocytopenia prevention in cancer patients. Due to its functional similarity with IL-6, IL-11 was less explored for many years. However, recently, IL-11 regained attention because its role in a diverse range of biological activities and diseases, especially in inflammations and cancers, were revealed. In this review, different aspects of IL-11 features, from structural points to clinical findings, are discussed, and bioinformatics tools are employed...
Source: Cytokine and Growth Factor Reviews - June 4, 2016 Category: Molecular Biology Authors: Manica Negahdaripour, Navid Nezafat, Younes Ghasemi Tags: Survey Source Type: research
Deep insights into IL-11: A panoramic review and in silico approach
Interleukin (IL)-11 is a multifunctional cytokine that was discovered almost 25 years ago. IL-11 has megakaryocytopoiesis activity, which led to its clinical indication for thrombocytopenia prevention in cancer patients. Due to its functional similarity with IL-6, IL-11 was less explored for many years. However, recently, IL-11 regained attention because its role in a diverse range of biological activities and diseases, especially in inflammations and cancers, were revealed. In this review, different aspects of IL-11 features, from structural points to clinical findings, are discussed, and bioinformatics tools are employed...
Source: Cytokine and Growth Factor Reviews - June 4, 2016 Category: Molecular Biology Authors: Manica Negahdaripour, Navid Nezafat, Younes Ghasemi Tags: Survey Source Type: research
Cytokines 2015 – A most memorable meeting
The 2015 Annual Meeting of ICIS in beautiful Bamberg, a UNESCO world heritage site in Germany, will be remembered for its outstanding science, its friendly atmosphere, and an extraordinarily interactive and stimulating setting. The meeting took place on the premises of the Bamberg Symphony Orchestra, which provided an ideal environment to discuss the nature of cytokines and their many roles in health and disease. Outstanding presentations by a fantastic line-up of speakers highlighted the most recent developments in the field. (Source: Cytokine and Growth Factor Reviews)
Source: Cytokine and Growth Factor Reviews - May 31, 2016 Category: Molecular Biology Tags: Editorial Source Type: research
Editorial Board and Publication information
(Source: Cytokine and Growth Factor Reviews)
Source: Cytokine and Growth Factor Reviews - May 31, 2016 Category: Molecular Biology Source Type: research
Cytokines 2015 – A most memorable meeting
The 2015 Annual Meeting of ICIS in beautiful Bamberg, a UNESCO world heritage site in Germany, will be remembered for its outstanding science, its friendly atmosphere, and an extraordinarily interactive and stimulating setting. The meeting took place on the premises of the Bamberg Symphony Orchestra, which provided an ideal environment to discuss the nature of cytokines and their many roles in health and disease. Outstanding presentations by a fantastic line-up of speakers highlighted the most recent developments in the field. (Source: Cytokine and Growth Factor Reviews)
Source: Cytokine and Growth Factor Reviews - May 31, 2016 Category: Molecular Biology Tags: Editorial Source Type: research
Editorial Board and Publication information
(Source: Cytokine and Growth Factor Reviews)
Source: Cytokine and Growth Factor Reviews - May 31, 2016 Category: Molecular Biology Source Type: research
