Endocytic regulation of cytokine receptor signaling

Endocytosis is coupled to regulation of signaling initiated by plasma membrane receptors. Initially, internalization of the activated receptors was considered only as a means for signal attenuation, but now it is clear that endocytosis also regulates the duration of receptor signaling as well as specificity of signaling outputs (reviewed in Barbieri et al. [1]). Endosomes can serve as mobile signaling platforms facilitating formation of multiprotein signaling assemblies and therefore enabling efficient signal transduction in space and time.
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Tags: Mini review Source Type: research