Crosstalk between insulin-like growth factor (IGF) receptor and integrins through direct integrin binding to IGF1

Insulin-like growth factor-1 (IGF1) is a polypeptide hormone that is homologous to proinsulin. Most of (80%) of the IGF1 in serum is synthesized by the liver and secreted, and it functions as an endocrine hormone. The remaining 20% of the IGF1 is synthesized in the periphery. Usually, connective tissue cell types, such as stromal cells, and IGF1 that is synthesized in the periphery can function to regulate cell survival by autocrine and paracrine mechanisms [1]. IGF1 is also secreted by many cancer cells at abnormally high levels.
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Tags: Mini review Source Type: research