Post-transcriptional regulation of cytokine and growth factor signaling in cancer

In addition to regulating cell proliferation, differentiation, and apoptosis, cytokines and growth factors also play important roles in coordinating growth signal responses during development. The ability of cytokines to affect cellular self-renewal capacity, migration, senescence, or apoptosis is often impaired in cancer. PubMed citations include approximately 7000 publications related to abnormal cytokine and growth factor signaling in cancer. Researchers have shown altered levels of expression or function of numerous cytokines, including growth factors and chemokines in malignant tissues relative to healthy tissues (reviewed in [1,2]).
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Tags: Survey Source Type: research