The prognostic value of serum C-reactive protein-bound serum amyloid A in early-stage lung cancer.
CONCLUSION: CRP-SAA could be a better prognostic marker for lung cancer than total SAA or CRP, especially in early-stage patients.
PMID: 26264146 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - August 15, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Clinical parameters predicting pathologic complete response following neoadjuvant chemoradiotherapy for rectal cancer.
CONCLUSIONS: The pretreatment CEA level and neoadjuvant chemoradiotherapy-surgery interval were independent clinical predictors for achieving pCR. These results may help clinicians predict the prognosis of patients and develop adaptive treatment strategies.
PMID: 26268466 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - August 15, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Incidence trends and age distribution of colorectal cancer by subsite in Guangzhou, 2000-2011.
CONCLUSIONS: The crude incidence of CRC increased significantly between 2000 and 2011 because of the aging, whereas the ASRs kept stable. The percentage of colon cancer in all CRCs increased significantly. Further surveillance, research, and intervention are needed to identify the causes of these changes and to reduce the incidence and mortality of CRC.
PMID: 26245843 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - August 10, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Effects of subsampling on characteristics of RNA-seq data from triple-negative breast cancer patients.
CONCLUSIONS: Our results reveal important characteristics of RNA-seq data that must be understood before one can apply such an approach to translational medicine.
PMID: 26253000 [PubMed - as supplied by publisher] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - August 10, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Can radical parametrectomy be omitted in occult cervical cancer after extrafascial hysterectomy?
CONCLUSIONS: Perioperative complications following RP were common, whereas the incidence of parametrial involvement was very low among selected early-stage cervical cancer patients. Based on these results, we thought that patients with very low-risk parametrial involvement(tumor size ≤2 cm, no LVSI, less than 50% stromal invasion, negative lymph nodes) may benefit from omitting RP. Further prospective data are warranted.
PMID: 26253113 [PubMed - as supplied by publisher] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - August 10, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Carcinogenic effects of circadian disruption: an epigenetic viewpoint.
Authors: Salavaty A
Abstract
Circadian rhythms refer to the endogenous rhythms that are generated to synchronize physiology and behavior with 24-h environmental cues. These rhythms are regulated by both external cues and molecular clock mechanisms in almost all cells. Disruption of circadian rhythms, which is called circadian disruption, affects many biological processes within the body and results in different long-term diseases, including cancer. Circadian regulatory pathways result in rhythmic epigenetic modifications and the formation of circadian epigenomes. Aberrant epigenetic modifications, such as ...
Source: Chinese Journal of Cancer - August 10, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Clinicopathologic characteristics and therapeutic responses of Chinese patients with non-small cell lung cancer who harbor an anaplastic lymphoma kinase rearrangement.
CONCLUSIONS: ALK-rearranged NSCLC tends to occur in younger individuals who are either non-smokers or light smokers with adenocarcinoma. Patients with ALK rearrangement might benefit from ALK inhibitor therapy.
PMID: 26253541 [PubMed - as supplied by publisher] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - August 10, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Secular trend analysis of lung cancer incidence in Sihui city, China between 1987 and 2011.
CONCLUSIONS: Increasing trends of the incidence of lung cancer in Sihui were dominated by the effects of age and birth cohorts. Social aging, smoking, and environmental changes may play important roles in such trends.
PMID: 26227634 [PubMed - as supplied by publisher] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - August 2, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Global efforts in conquering lung cancer in China.
Authors: Yan L, Xu L
Abstract
Lung cancer, the most prevalent and deadly malignancy in the world, poses a particularly critical healthcare challenge to China due to the rapidly increasing new cases and the unique cancer genetics in Chinese patient population. Substantial progress has been made in molecular diagnosis and personalized treatment of the disease. The field is now moving towards multiple new directions to include (1) new generation of targeted agents such as epidermal growth factor receptor and anaplastic lymphoma kinase inhibitors to overcome resistance to their early generation counterparts; a...
Source: Chinese Journal of Cancer - July 31, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Targeted therapies for patients with advanced NSCLC harboring wild-type EGFR: what's new and what's enough.
Authors: Zhou F, Zhou CC
Abstract
Historically, non-small cell lung cancer (NSCLC) is divided into squamous and nonsquamous subtypes based on histologic features. With a growing number of oncogenic drivers being identified in squamous and nonsquamous NSCLC, this malignancy has been recently divided into several distinct subtypes according to the specific molecular alterations. This new paradigm has substantially highlighted the treatment of advanced NSCLC, shifting it from standard chemotherapy according to specific histologic subtypes to targeted therapy according to specific oncogenic drivers. The applic...
Source: Chinese Journal of Cancer - July 21, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Anti-tumor activities and apoptotic mechanism of ribosome-inactivating proteins.
Authors: Zeng M, Zheng M, Lu D, Wang J, Jiang W, Sha O
Abstract
Ribosome-inactivating proteins (RIPs) belong to a family of enzymes that attack eukaryotic ribosomes and potently inhibit cellular protein synthesis. RIPs possess several biomedical properties, including anti-viral and anti-tumor activities. Multiple RIPs are known to inhibit tumor cell proliferation through inducing apoptosis in a variety of cancers, such as breast cancer, leukemia/lymphoma, and hepatoma. This review focuses on the anti-tumor activities of RIPs and their apoptotic effects through three closely related pathways: mitochondrial,...
Source: Chinese Journal of Cancer - July 18, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Insight into early-phase trials for lung cancer in the United States.
CONCLUSIONS: These data suggest that a significantly higher percentage of phase 1 trials for lung cancer were conducted in the US than in China. Early-phase oncology trials with robust preclinical data had a higher chance of being approved by the Investigational Drug Branch at the CTEP/NCI. Given the importance of early-phase oncology trials in developing innovative cancer medicines, such studies should be highly encouraged and strategically funded in China.
PMID: 26162603 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - July 15, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Parallel phase 1 clinical trials in the US and in China: accelerating the test of avitinib in lung cancer as a novel inhibitor selectively targeting mutated EGFR and overcoming T790M-induced resistance.
Authors: Xu X
Abstract
Avitinib, a new generation inhibitor of epidermal growth factor receptor (EGFR), was approved for clinical trial in both China and the United States, and the phase 1 trials were initiated in both countries in parallel. In the preclinical studies, avitinib showed three novel features including (1) irreversibly binding EGFR by forming a covalent bound with Cys 797 in the ATP-binding pocket, (2) sparing wild-type EGFR, and (3) overcoming T790M-induced resistance. Avitinib is the first China-developed novel EGFR inhibitor that has entered in global clinical trials, and will provide a pre...
Source: Chinese Journal of Cancer - July 11, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Early-Phase Oncology Research Training (EFFORT) program: a Hengrui-USCACA joint scholarship.
Authors: Yan L, Xu L
PMID: 26152230 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - July 11, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Predictive biomarkers in precision medicine and drug development against lung cancer.
Authors: Fang B, Mehran RJ, Heymach JV, Swisher SG
Abstract
The molecular characterization of various cancers has shown that cancers with the same origins, histopathologic diagnoses, and clinical stages can be highly heterogeneous in their genetic and epigenetic alterations that cause tumorigenesis. A number of cancer driver genes with functional abnormalities that trigger malignant transformation and that are required for the survival of cancer cells have been identified. Therapeutic agents targeting some of these cancer drivers have been successfully developed, resulting in substantial improvements in cl...
Source: Chinese Journal of Cancer - July 5, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
