Expert consensus on robotic surgery for colorectal cancer (2015 edition).
Authors: Xu J, Qin X
PMID: 26916742 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - February 29, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Twenty years after: the beautiful hypothesis and the ugly facts.
Authors: Pezzella F, Gatter K, Qian CN
Abstract
The limited clinical benefits from current antiangiogenic therapy for cancer patients have triggered some critical thoughts and insightful investigations aiming to further elucidate the relationship between vessels and cancer. Tumors need blood perfusion but there are mounting evidences that angiogenesis alone does not explain it in all the neoplasms. In this editorial, for a special issue on tumor and vessels published in the Chinese Journal of Cancer, we briefly introduce the history of the evidences that solid tumors can sometimes obtain blood perfusion by...
Source: Chinese Journal of Cancer - February 27, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Why some tumours trigger neovascularisation and others don't: the story thus far.
CONCLUSIONS: Our observations thus far indicate that both angiogenic and non-angiogenic tumours experience hypoxia/HIF and vascular endothelial growth factor (VEGF) pathway protein expression in a comparable fashion. However, angiogenesis does not ensue in the non-angiogenic tumours. Surprisingly, metabolic reprogramming seems to distinguish these two types of neoplastic growth. On the basis of these results, we raise the hypothesis that in some, but not in all cases, initial tissue remodeling and/or inflammation could be one of the secondary steps necessary to trigger angiogenesis. In the non-angiogenic tumours, in which ...
Source: Chinese Journal of Cancer - February 19, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Mechanisms of vascularization in murine models of primary and metastatic tumor growth.
Authors: Bugyik E, Renyi-Vamos F, Szabo V, Dezso K, Ecker N, Rokusz A, Nagy P, Dome B, Paku S
Abstract
Directed capillary ingrowth has long been considered synonymous with tumor vascularization. However, the vasculature of primary tumors and metastases is not necessarily formed by endothelial cell sprouting; instead, malignant tumors can acquire blood vessels via alternative vascularization mechanisms, such as intussusceptive microvascular growth, vessel co-option, and glomeruloid angiogenesis. Importantly, in response to anti-angiogenic therapies, malignant tumors can switch from one vascularization mecha...
Source: Chinese Journal of Cancer - February 19, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Long-term outcomes of a phase II randomized controlled trial comparing intensity-modulated radiotherapy with or without weekly cisplatin for the treatment of locally recurrent nasopharyngeal carcinoma.
CONCLUSION: Compared with radiotherapy alone, concomitant chemoradiotherapy can improve OS of the patients with locally recurrent NPC, especially those with advanced T category (rT3-4) and stage (III-IV) diseases, recurrence intervals >30 months, and tumor volume >26 cm(3).
PMID: 26879049 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - February 19, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Future options of anti-angiogenic cancer therapy.
Authors: Cao Y
Abstract
In human patients, drugs that block tumor vessel growth are widely used to treat a variety of cancer types. Many rigorous phase 3 clinical trials have demonstrated significant survival benefits; however, the addition of an anti-angiogenic component to conventional therapeutic modalities has generally produced modest survival benefits for cancer patients. Currently, it is unclear why these clinically available drugs targeting the same angiogenic pathways produce dissimilar effects in preclinical models and human patients. In this article, we discuss possible mechanisms of various ant...
Source: Chinese Journal of Cancer - February 19, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Frederick W. Alt received the 2015 Szent-Györgi Prize for Progress in Cancer Research.
This report highlights the pioneering work led by the 2015 Prize winner, Dr. Frederick Alt. Dr. Alt's work in the area of cancer genetics over four decades has helped to shape the very roots of modern cancer research. His work continues to profoundly impact the approaches that doctors around the globe use to diagnose and treat cancer. In particular, his seminal discoveries of gene amplification and his pioneering work on molecular mechanisms of DNA damage repair have helped to usher in the era of genetically targeted therapy and personalized medicine.
PMID: 26843073 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - February 9, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Comparisons of biophysical properties and bioactivities of mono-PEGylated endostatin and an endostatin analog.
CONCLUSIONS: M2ES has a more compact tertiary structure, is more stable for trypsin digestion and GdmCl-induced unfolding, exhibits increased cellular uptake and shows equivalent inhibitory effects on cell migration relative to MZBP-ES, indicating that M2ES is a more promising candidate for anticancer drug development compared with MZBP-ES.
PMID: 26792627 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - January 24, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Segmental ureteroileal conduit resection for the treatment of distal upper urinary tract recurrence of bladder cancer following cystectomy.
This study was to determine the feasibility of segmental ureteroileal conduit resection (SUICR) for patients with distal upper urinary tract recurrence of bladder cancer following radical cystectomy. Four patients with high-grade distal upper urinary tract recurrence underwent SUICR 15-108 months after radical cystectomy. The surgical technique details of SUICR, operative results, and follow-up outcomes are reported. The median operation time was 280 min, and estimated blood loss was less than 100 mL. One patient suffered from ileus 5 days after surgery and was managed conservatively. Histopathologic evaluation showed ...
Source: Chinese Journal of Cancer - January 24, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Co-infection of Epstein-Barr virus and human papillomavirus in human tumorigenesis.
Authors: Shi Y, Peng SL, Yang LF, Chen X, Tao YG, Cao Y
Abstract
Viral infections contribute to approximately 12% of cancers worldwide, with the vast majority occurring in developing countries and areas. Two DNA viruses, Epstein-Barr virus (EBV) and human papillomavirus (HPV), are associated with 38% of all virus-associated cancers. The probability of one patient infected with these two distinct types of viruses is increasing. Here, we summarize the co-infection of EBV and HPV in human malignancies and address the possible mechanisms for the co-infection of EBV and HPV during tumorigenesis.
PMID: 2...
Source: Chinese Journal of Cancer - January 24, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Cumulative scores based on plasma D-dimer and serum albumin levels predict survival in esophageal squamous cell carcinoma patients treated with transthoracic esophagectomy.
CONCLUSIONS: Our study suggests that preoperative DA scores are notably associated with postoperative survival of ESCC patients.
PMID: 26754834 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - January 17, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Genomic profiling of lower-grade gliomas uncovers cohesive disease groups: implications for diagnosis and treatment.
Authors: Zhang CM, Brat DJ
Abstract
Lower-grade gliomas (including low- and intermediate-grade gliomas, World Health Organization grades II and III) are diffusely infiltrative neoplasms that arise most often in the cerebral hemispheres of adults and have traditionally been classified based on their presumed histogenesis as astrocytomas, oligodendrogliomas, or oligoastrocytomas. Although the histopathologic classification of lower-grade glioma has been the accepted standard for nearly a century, it suffers from high intra- and inter-observer variability and does not adequately predict clinical outcomes. Bas...
Source: Chinese Journal of Cancer - January 17, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Expert consensus on maintenance treatment for metastatic colorectal cancer in China.
Authors: Xu RH, Shen L, Li J, Xu JM, Bi F, Ba Y, Bai L, Shu YQ, Liu TS, Li YH, Bai CM, Yuan XL, Zhang J, Chen G, Zhou AP, Yuan Y, Wang XJ, Qian XP, Deng YH
Abstract
The impact of maintenance therapy on progression-free survival and overall survival as well as quality of life of Chinese patients with metastatic colorectal cancer has long been under discussion. Recently, some phase III clinical trials have revealed that maintenance therapy can significantly prolong the progression-free survival while maintain an acceptable safety profile. Based on this evidence and common treatment practice in China, we now ...
Source: Chinese Journal of Cancer - January 17, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Occipital lymph node metastasis from nasopharyngeal carcinoma: a special case report and literature review.
Authors: Yang J, Xia WX, Xiang YQ, Lv X, Ke LR, Yu YH, Guo X
Abstract
Cervical lymph node metastasis is common in patients with nasopharyngeal carcinoma (NPC), but occipital lymph node metastasis in NPC patients has not yet been reported. In this case report, we describe an NPC patient with occipital lymph node metastasis. The clinical presentation, diagnostic procedure, treatment, and outcome of this case were presented, with a review of the related literature.
PMID: 26728009 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - January 12, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Roles of low-density lipoprotein receptor-related protein 1 in tumors.
Authors: Xing P, Liao Z, Ren Z, Zhao J, Song F, Wang G, Chen K, Yang J
Abstract
Low-density lipoprotein receptor-related protein 1 (LRP1, also known as CD91), a multifunctional endocytic and cell signaling receptor, is widely expressed on the surface of multiple cell types such as hepatocytes, fibroblasts, neurons, astrocytes, macrophages, smooth muscle cells, and malignant cells. Emerging in vitro and in vivo evidence demonstrates that LRP1 is critically involved in many processes that drive tumorigenesis and tumor progression. For example, LRP1 not only promotes tumor cell migration and invasion by regul...
Source: Chinese Journal of Cancer - January 12, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
