Gastric cancer: current and evolving treatment landscape.
Authors: Sun W, Yan L
Abstract
Gastric (including gastroesophageal junction) cancer is the third leading cause of cancer-related death in the world. In China, an estimated 420,000 patients were diagnosed with gastric cancer in 2011, ranking this malignancy the second most prevalent cancer type and resulting in near 300,000 deaths. The treatment landscape of gastric cancer has evolved in recent years. Although systemic chemotherapy is still the mainstay treatment of metastatic disease, the introduction of agents targeting human epidermal growth factor receptor 2 and vascular endothelial growth factor/vascul...
Source: Chinese Journal of Cancer - September 2, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
The journey of personalizing gastric cancer treatment.
Authors: Yan L
Abstract
Gastric cancer ranks the fourth most prevalent malignancy yet it is the second leading cause of cancer-related death. Every year, gastric cancer adds nearly 1 million new cancer cases, and 723,000 or 10% of cancer deaths to the global cancer burden. Approximately, 405,000 or 43% of the new cases and 325,000 or 45% of the deaths are in China, making gastric cancer a particularly challenging malignancy. This thematic series discusses the molecular classifications of gastric cancer by the Cancer Genome Atlas (TCGA) and the Asian Cancer Research Group (ACRG) as well as the implications ...
Source: Chinese Journal of Cancer - September 2, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Combined hepatocellular and cholangiocarcinoma originating from the same clone: a pathomolecular evidence-based study.
CONCLUSIONS: Our results suggest that the HCC and ICC components of CHC may originate from the same clone, having the potential for dual-directional differentiation similar to HPCs. CHC tended to exhibit the biological behaviors of both HCC and ICC, which may enhance the infiltrative capacity of tumor cells, leading to poor clinical outcomes for patients with CHC.
PMID: 27552844 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - August 26, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Subtype distribution and long-term titer fluctuation patterns of serum anti-Epstein-Barr virus antibodies in a non-nasopharyngeal carcinoma population from an endemic area in South China: a cohort study.
CONCLUSIONS: Age- and sex-specific cutoff titer values for serum anti-EBV antibodies as well as their specific titer fluctuation patterns should be considered when defining high NPC risk criteria for follow-up diagnostics and monitoring.
PMID: 27527073 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - August 18, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Clinical and molecular characteristics of East Asian patients with von Hippel-Lindau syndrome.
CONCLUSIONS: Evidence suggests that the genotypic and phenotypic characteristics of East Asian patients with VHL syndrome differ from other populations. This should be considered when making screening recommendations for VHL syndrome in Asia.
PMID: 27527340 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - August 18, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Prognostic factors affecting postoperative survival of patients with solitary small hepatocellular carcinoma.
CONCLUSIONS: Tumor size and vascular invasion are feasible and useful prognostic factors for sHCC. The proposed prognostic model, based on tumor size and vascular invasion, is informative in predicting survival in sHCC patients undergoing hepatectomy.
PMID: 27527497 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - August 18, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Association of microRNA polymorphisms with the risk of head and neck squamous cell carcinoma in a Chinese population: a case-control study.
CONCLUSION: Our study provided the evidence that miR-605 rs2043556 and miR-196a2 rs11614913 may have an impact on genetic susceptibility to OSCC in Chinese population.
PMID: 27515039 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - August 16, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
A comprehensive genomic characterization of esophageal squamous cell carcinoma: from prognostic analysis to in vivo assay.
CONCLUSIONS: We found the independent ESCC survival predictors and potential therapy targets. Nevertheless, the effects of numerous low-frequency mutations need to be explored using larger sample sequencing. Overall, constructing multi-gene prognostic signatures will remain a great challenge in the future.
PMID: 27515178 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - August 16, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Overweight/obese status associates with favorable outcome in patients with metastatic nasopharyngeal carcinoma: a 10-year retrospective study.
CONCLUSION: For patients with metastatic NPC, overweight/obese status was associated with longer OS but not longer PFS compared with underweight or normal weight status.
PMID: 27507261 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - August 13, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Leveraging the power of pooled data for cancer outcomes research.
CONCLUSION: As China and other Asian countries continue to conduct oncology clinical trials, efforts to collate patient-level information from these studies into a large data repository should be strongly considered since pooled data can increase future capacity for cancer outcomes research, which, in turn, can enhance patient-physician discussions and optimize clinical care.
PMID: 27484162 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - August 5, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
The incidence and mortality of major cancers in China, 2012.
CONCLUSIONS: Continuous cancer registry data provides basic information in cancer control programs. The cancer burden in China is gradually increasing, both in urban and rural areas, in males and females. Efficient cancer prevention and control, such as health education, tobacco control, and cancer screening, should be paid attention by the health sector and the whole society of China.
PMID: 27484217 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - August 5, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Epidemiology of lung cancer and approaches for its prediction: a systematic review and analysis.
CONCLUSIONS: Our findings provide an inclusive understanding of the incidences, mortalities, and survival rates of lung cancer in the UK, the US, India, and Egypt. The combined use of data mining and evolutionary algorithm can be efficient in lung cancer detection.
PMID: 27473753 [PubMed - as supplied by publisher] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - August 1, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Chromatin remodeling factor LSH affects fumarate hydratase as a cancer driver.
Authors: Liu S, Tao YG
Abstract
Cancer metabolism and epigenetic alteration are two critical mechanisms for tumorigenesis and cancer progression; however, the dynamic interplay between them remains poorly understood. As reported in the article entitled "Chromatin remodeling factor LSH drives cancer progression by suppressing the activity of fumarate hydratase," which was recently published in Cancer Research, our group examined the physiological role of lymphocyte-specific helicase (LSH) in nasopharyngeal carcinoma (NPC) by focusing on cancer progression and the tricarboxylic acid cycle. We found that LSH ...
Source: Chinese Journal of Cancer - August 1, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
EYA4 gene functions as a prognostic marker and inhibits the growth of intrahepatic cholangiocarcinoma.
CONCLUSION: EYA4 gene functioned as a molecular prognostic marker in ICC, and its overexpression inhibited tumor growth in vitro and in vivo.
PMID: 27469137 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - July 30, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Evolution of gastric surgery techniques and outcomes.
Authors: Shiozaki H, Shimodaira Y, Elimova E, Wadhwa R, Sudo K, Harada K, Estrella JS, Das P, Badgwell B, Ajani JA
Abstract
Surgical management of gastric cancer improves survival. However, for some time, surgeons have had diverse opinions about the extent of gastrectomy. Researchers have conducted many clinical studies, making slow but steady progress in determining the optimal surgical approach. The extent of lymph node dissection has been one of the major issues in surgery for gastric cancer. Many trials demonstrated that D2 dissection resulted in greater morbidity and mortality than D1 dissection. Howe...
Source: Chinese Journal of Cancer - July 29, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
