Pathobiology of ovarian carcinomas.
We report herein the newly described molecular abnormalities in epithelial ovarian cancers (carcinomas). Immunohistochemistry and molecular testing help pathologists to decipher the significant heterogeneity of this disease. Our better understanding of the molecular basis of ovarian carcinomas represents the first step in the development of targeted therapies in the near future.
PMID: 25556618 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - January 10, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Fertility preservation in female cancer patients: a single center experience.
Authors: Sigismondi C, Papaleo E, Viganò P, Vailati S, Candiani M, Ottolina J, Di Mattei VE, Mangili G
Abstract
Advances in cancer treatment allow women to be cured and live longer. However, the necessary chemotherapy and radiotherapy regimens have a negative impact on future fertility. Oncofertility has emerged as a new interdisciplinary field to address the issue of gonadotoxicity associated with cancer treatment and to facilitate fertility preservation, including oocyte and ovarian tissue cryopreservation. These fertility issues are often inadequately addressed, and referral rates to oncofertility cent...
Source: Chinese Journal of Cancer - January 10, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Cancer immunotherapy.
Authors: Yan L, Chen HX
PMID: 25513442 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - December 18, 2014 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Cancer immunotherapy.
Authors: Yan L, Chen HX
PMID: 25478631 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - December 7, 2014 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Toxic epidermal necrolysis related to AP (pemetrexed plus cisplatin) and gefitinib combination therapy in apatient with metastatic non-small cell lung cancer.
We report rare presentation of TEN involving adverse effects of AP and gefitinib combination treatment in a 42-year-old woman diagnosed with metastatic NSCLC harboring an EGFR mutation. On the 21st day after administration of the first cycle of AP and the 8th day after the initiation of gefitinib, she developed an acne-like rash, oral ulcer, and conjunctivitis, which later became blisters and ultimately denuded. The characteristic clinical courses were decisive for the diagnosis of TEN. Treatment with systemic steroids and immunoglobulin as well as supportive treatment led to an improvement of her general condition and a r...
Source: Chinese Journal of Cancer - December 1, 2014 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Optimal follow-up time for evaluatingobjective response to radiotherapy in patients with hepatocellular carcinoma: a retrospective study.
The objective response rates increased over time from 15.4% at 3 months to 71.8% at 6 months and 87.2% at 9 months. Age60 years old or older and post-radiotherapy α-fetoprotein concentrations higher than pre-radiotherapy concentrationspredicted delayed treatment response.The objective response rate continued toincrease over 9 months. Therefore, to fully evaluate the treatment response of HCC, we recommend continuous observationfor at least 9 months after radiotherapy.
PMID: 25418189 [PubMed - as supplied by publisher] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - December 1, 2014 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Epstein-Barr virus and the origin of Hodgkin lymphoma.
This article reviews what is known about the contribution of EBV to the pathogenesis of cHL and focus on emerging evidence implicating chronic inflammation as a potential oncogenic co-factor in this malignancy.
PMID: 25418190 [PubMed - as supplied by publisher] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - December 1, 2014 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Breakthrough cancer medicine and its impact on novel drug development in China: report of the US Chinese Anti-Cancer Association (USCACA) and Chinese Society of Clinical Oncology (CSCO) Joint Session at the 17th CSCO Annual Meeting.
Authors: Luo R, Ding J, Chen H, Liu H, Fung MC, Koehler M, Armand JP, Jiang L, Xu X, Zhang G, Xu L, Qian P, Yan L
Abstract
USCACA teamed up with Chinese Society of Clinical Oncology (CSCO) to host a joint session at the17thCSCO Annual Meeting on September 20th, 2014 in Xiamen, China. With a focus on breakthrough cancer medicines, the session featured innovative approaches to evaluate breakthrough agents and established a platform to interactively share successful experiences from case studies of 6 novel agents from both US and China. The goal of the session is to inspire scientific and practical considerat...
Source: Chinese Journal of Cancer - December 1, 2014 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Investigation of osteosarcoma genomics and its impact on targeted therapy: an international collaboration to conquer human osteosarcoma.
Authors: Yang JL
Abstract
Osteosarcoma is a genetically unstable malignancy that most frequently occurs in children and young adults. The lack of progress in managing this devastating disease in the clinic has prompted international researchers to collaborate to profile key genomic alterations that define osteosarcoma. A team of researchers and clinicians from China, Finland, and the United States investigated human osteosarcoma by integrating transcriptome sequencing (RNA-seq), high-density genome-wide array comparative genomic hybridization (aCGH), fluorescence in situ hybridization (FISH), reverse trans...
Source: Chinese Journal of Cancer - December 1, 2014 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Epstein-Barr virus and nasopharyngeal carcinoma.
Authors: Young LS, Dawson CW
Abstract
Since its discovery 50 years ago, Epstein-Barr virus (EBV) has been linked to the development of cancers originating from both lymphoid and epithelial cells. Approximately 95% of the world's population sustains an asymptomatic, life-long infection with EBV. The virus persists in the memory B-cell pool of normal healthy individuals, and any disruption of this interaction results in virus-associated B-cell tumors. The association of EBV with epithelial cell tumors, specifically nasopharyngeal carcinoma (NPC) and EBV-positive gastric carcinoma (EBV-GC), is less clear and ...
Source: Chinese Journal of Cancer - December 1, 2014 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Plasma Epstein-Barr virus DNA as a biomarker for nasopharyngeal carcinoma.
Authors: Chan KC
Abstract
Nasopharyngeal carcinoma (NPC) is common in southern China and Southeast Asia. Epstein-Barr virus (EBV) infection is an important etiology for NPC, and EBV genome can be detected in almost all tumor tissues of NPC in this region. Quantitative measurement of plasma EBV DNA using real-time polymerase chain reaction (PCR) analysis has developed as a biomarker for NPC. In this review, the different clinical applications of plasma EBV DNA in the management of NPC, including screening, monitoring and prognostication, are discussed. In addition, the biological issues of circulating EBV D...
Source: Chinese Journal of Cancer - December 1, 2014 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Epstein-Barr virus and Burkitt lymphoma.
Authors: Rowe M, Fitzsimmons L, Bell AI
Abstract
In 1964, a new herpesvirus, Epstein-Barr virus (EBV), was discovered in cultured tumor cells derived from a Burkitt lymphoma (BL) biopsy taken from an African patient. This was a momentous event that reinvigorated research into viruses as a possible cause of human cancers. Subsequent studies demonstrated that the EBV was a potent growth-transforming agent for primary B cells, and that all cases of BL carried characteristic chromosomal translocations resulting in constitutive activation of the c-MYC oncogene. These results hinted at simple oncogenic mechanism...
Source: Chinese Journal of Cancer - December 1, 2014 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Use of subsequent PET/CT in diffuse large B-cell lymphoma patients in complete remission following primary therapy.
In conclusion, our results indicate that I-PET/CT should be performed after 2 rather than 4 cycles of immunochemotherapy in DLBCL patients. There is a limited role for subsequent PET/CT in the detection of relapse in PET/CT2-negative patients, but repeat PET/CT is required if the PET/CT2 findings are positive.
PMID: 25418196 [PubMed - as supplied by publisher] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - December 1, 2014 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Intraarterial chemotherapy with gemcitabine and cisplatin in locally advanced or recurrent penile squamous cell carcinoma.
This study aimed to evaluate the therapeutic effects of intraarterial chemotherapy with gemcitabine and cisplatin on locally advanced or recurrent SCC of the penis. Between April 1999 and May 2011, we treated 5 patients with locally advanced penile SCC and 7 patients with recurrent disease with intraarterial chemotherapy. The response rate and toxicity data were analyzed, and survival rates were calculated. After 2 to 6 cycles of intraarterial chemotherapy with gemcitabine and cisplatin, 1 patients with locoregionally advanced disease achieved a complete response, and 4 achieved partial response. Of the 7 patients with rec...
Source: Chinese Journal of Cancer - November 19, 2014 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Clinical implications of microRNAs in liver cancer stem cells.
Authors: Chai S, Ma S
Abstract
The prognosis of patients diagnosed with hepatocellular carcinoma (HCC) is often dismal, mainly due to late presentation, high recurrence rate, and frequent resistance to chemotherapy and radiotherapy. Accumulating evidence on the differential microRNA (miRNA) expression patterns between non-tumor and HCC tissues or between liver cancer stem cells (CSCs) and non-CSC subsets and the significant clinical implications of these differences suggest that miRNAs are a promising, non-invasive marker for the prognosis and diagnosis of the disease. This perspective article summarizes t...
Source: Chinese Journal of Cancer - November 19, 2014 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
