Systematic analyses of glutamine and glutamate metabolisms across different cancer types.
CONCLUSIONS: We comprehensively predicted the roles of glutamine and glutamate metabolisms in selected metabolic pathways in cancer tissues versus control tissues, which may lead to novel approaches to therapeutic development targeted at glutamine and/or glutamate metabolism. However, our predictions need further functional validation.
PMID: 29116024 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - November 9, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
The 150 most important questions in cancer research and clinical oncology series: questions 67-75 : Edited by Chinese Journal of Cancer.
Authors: Chinese Journal of Cancer
Abstract
Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology, which sparkle diverse thoughts, interesting communications, and potential collaborations among researchers all over the world. In this article, 9 more questions are presented as followed. Question 67. How could we overcome the resistance of hepatocellular carcinoma against chemotherapeutics? Question 68. Is pursuit of non-covalent small-molecule binders of RAS proteins viable as a strategy of cancer drug discovery? Questio...
Source: Chinese Journal of Cancer - November 3, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Conditional survival in patients with gallbladder cancer.
CONCLUSIONS: T and M categories were significant prognostic factors even 5 years after the initial diagnosis, whereas local treatments at the time of diagnosis were not, suggesting that patients with GB cancer at high risks might need further adjuvant therapy after primary treatments. The combined analysis of CSS and cancer-specific CS rates offered more accurate survival information for patients who have already survived a certain period of time after diagnosis.
PMID: 29084608 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - November 2, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
The influence of stage at diagnosis and molecular subtype on breast cancer patient survival: a hospital-based multi-center study.
CONCLUSIONS: Survival of breast cancer patients varied significantly by stage and molecular subtype. Cancer screening is encouraged for the early detection and early diagnosis of breast cancer. More advanced therapies and health care policies are needed on HER2 and triple-negative subtypes.
PMID: 29070080 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - October 27, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Hepatic artery infusion chemotherapy using mFOLFOX versus transarterial chemoembolization for massive unresectable hepatocellular carcinoma: a prospective non-randomized study.
CONCLUSIONS: HAIC with mFOLFOX yielded significantly better treatment responses and less serious toxicity than did TACE. HAIC might represent a feasible and promising first-line treatment for patients with massive unresectable HCC.
PMID: 29061175 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - October 26, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Chromatin remodeling factor lymphoid-specific helicase inhibits ferroptosis through lipid metabolic genes in lung cancer progression.
Authors: Jiang Y, He Y, Liu S, Tao Y
PMID: 29037212 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - October 20, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Clinicopathologic features and treatment efficacy of Chinese patients with BRAF-mutated metastatic colorectal cancer: a retrospective observational study.
CONCLUSIONS: BRAF V600E mutations were commonly identified in right-sided tumors and showed a high incidence of peritoneal and distant lymph nodes metastases. This subtype of mCRC was characterized by short OS and unique patterns of metastasis. Compared with standard treatment regimens, the FOLFOXIRI regimen had acceptable and manageable toxicities and favorable efficacy on patients with BRAF-mutated mCRC.
PMID: 29037218 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - October 20, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
The prognostic value of C-X-C motif chemokine receptor 4 in patients with sporadic malignant peripheral nerve sheath tumors.
CONCLUSION: High CXCR4 expression may define a specific subtype of sporadic MPNST with favorable prognosis.
PMID: 29020982 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - October 13, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
The 150 most important questions in cancer research and clinical oncology series: questions 57-66 : Edited by Chinese Journal of Cancer.
Authors: Chinese Journal of Cancer
Abstract
Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology, which sparkle diverse thoughts, interesting communications, and potential collaborations among researchers all over the world. In this article, 10 more questions are presented as followed. Question 57. What are the major stresses that drive the formation, progression, and metastasis of a cancer? Question 58. What is the mechanism responsible for altering an acidic intracellular pH and a basic extracellular pH in normal tis...
Source: Chinese Journal of Cancer - October 6, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Pathologic response after preoperative therapy predicts prognosis of Chinese colorectal cancer patients with liver metastases.
CONCLUSIONS: We found that the evaluation of pathologic response may predict the prognosis of Chinese colorectal cancer patients with liver metastases after preoperative chemotherapy. Small tumor diameter, long-duration chemotherapy, left primary tumor, and decreased serum CEA level after chemotherapy are associated with increased pathologic response rates.
PMID: 28969708 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - October 5, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Tripartite motif-containing 3 (TRIM3) inhibits tumor growth and metastasis of liver cancer.
CONCLUSIONS: TRIM3 plays a tumor-suppressing role in the regulation of liver cancer development by reducing cell proliferation through cell cycle arrest at the G0/G1 phase.
PMID: 28950898 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - September 29, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Effects of dosimetric inadequacy on local control and toxicities in the patients with T4 nasopharyngeal carcinoma extending into the intracranial space and treated with intensity-modulated radiotherapy plus chemotherapy.
CONCLUSIONS: With relative underdosed IMRT plus effective chemotherapy, the patients achieved satisfactory local control with few late toxicities of the central nervous system. Determining the acceptable extent of dosimetric inadequacy requires further exploration.
PMID: 28931426 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - September 23, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Prognostic value of systemic immune-inflammation index in patients with gastric cancer.
CONCLUSION: Preoperative SII level is an independent prognostic factor for OS in patients with gastric cancer.
PMID: 28899420 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - September 15, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Efficacy and safety of controlled-release oxycodone/naloxone versus controlled-release oxycodone in Korean patients with cancer-related pain: a randomized controlled trial.
CONCLUSIONS: OXN-CR was non-inferior to OX-CR in terms of pain reduction after 4 weeks of treatment and had a similar safety profile. Studies in larger populations of Korean patients with cancer-related pain are needed to further investigate the effectiveness of OXN-CR for long-term pain control and constipation alleviation. Trial registration ClinicalTrials.gov NCT01313780, registered March 8, 2011.
PMID: 28893309 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - September 13, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Medical expenditure for esophageal cancer in China: a 10-year multicenter retrospective survey (2002-2011).
CONCLUSIONS: These conservative estimates suggested that medical expenditures for esophageal cancer in China substantially increased in the last 10 years, treatment for early-stage esophageal cancer costs less than that for advanced cases, and spending on drugs continued to account for a considerable proportion of the overall expenditure.
PMID: 28882179 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - September 10, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
