Association of perioperative blood pressure with long-term survival in rectal cancer patients.
CONCLUSIONS: High preoperative systolic BP was an independent risk factor for both CSS and DFS rates, and high postoperative systolic BP was significantly associated with a low CSS rate in rectal cancer patients. Additionally, our results suggest that rectal cancer patients may get survival benefit from BP control in perioperative care. However, further studies should be conducted to determine the association between BP and CSS and targets of BP control.
PMID: 27067550 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - April 15, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Cell-free circulating tumor DNA in cancer.
Authors: Qin Z, Ljubimov VA, Zhou C, Tong Y, Liang J
Abstract
Cancer is a common cause of death worldwide. Despite significant advances in cancer treatments, the morbidity and mortality are still enormous. Tumor heterogeneity, especially intratumoral heterogeneity, is a significant reason underlying difficulties in tumor treatment and failure of a number of current therapeutic modalities, even of molecularly targeted therapies. The development of a virtually noninvasive "liquid biopsy" from the blood has been attempted to characterize tumor heterogeneity. This review focuses on cell-free circulating tumor ...
Source: Chinese Journal of Cancer - April 9, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Forty-six cases of nasopharyngeal carcinoma treated with 50 Gy radiotherapy plus hematoporphyrin derivative: 20 years of follow-up and outcomes from the Sun Yat-sen University Cancer Center.
CONCLUSION: Some NPC patients were sensitive to 50 Gy radiotherapy plus HPD, and this sensitivity was characterized by long-term survival without significant late treatment morbidities.
PMID: 27056488 [PubMed - as supplied by publisher] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - April 9, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Primary site and regional lymph node involvement are independent prognostic factors for early-stage extranodal nasal-type natural killer/T cell lymphoma.
CONCLUSIONS: The primary site and regional lymph node involvement are independent prognostic factors for early-stage ENKTCL treated with chemotherapy followed by definitive radiotherapy.
PMID: 27044275 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - April 6, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Effect of preoperative injection of carbon nanoparticle suspension on the outcomes of selected patients with mid-low rectal cancer.
CONCLUSIONS: Injecting a carbon nanoparticle suspension improved the outcomes of patients who underwent laparoscopic resection for mid-low rectal cancer; it also improved the accuracy of pathologic staging. Moreover, for selected patients, this technique narrowed the scope of lateral lymph node dissection.
PMID: 27044280 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - April 6, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Prospective study found that peripheral lymph node sampling reduced the false-negative rate of sentinel lymph node biopsy for breast cancer.
CONCLUSIONS: The FNR of SLNB was associated with the number of SLNs. For patients with ≤3 detected SLNs, PLN sampling can reduce the FNR of SLNB to an acceptable level of less than 5%. Because of the existence of the "skip metastasis" and distinct metastasis patterns, the FNR of SLNB cannot be completely eliminated.
PMID: 27044285 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - April 6, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Altered expression of stromal interaction molecule (STIM)-calcium release-activated calcium channel protein (ORAI) and inositol 1,4,5-trisphosphate receptors (IP3Rs) in cancer: will they become a new battlefield for oncotherapy?
Authors: Wen J, Huang YC, Xiu HH, Shan ZM, Xu KQ
Abstract
The stromal interaction molecule (STIM)-calcium release-activated calcium channel protein (ORAI) and inositol 1,4,5-trisphosphate receptors (IP3Rs) play pivotal roles in the modulation of Ca(2+)-regulated pathways from gene transcription to cell apoptosis by driving calcium-dependent signaling processes. Increasing evidence has implicated the dysregulation of STIM-ORAI and IP3Rs in tumorigenesis and tumor progression. By controlling the activities, structure, and/or expression levels of these Ca(2+)-transporting proteins, malignant cancer cells can ...
Source: Chinese Journal of Cancer - March 27, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Accelerated partial breast irradiation: advances and controversies.
Authors: Akhtari M, Teh BS
Abstract
The management of localized breast cancer has changed dramatically over the past three to four decades. Breast-conserving therapy, which involved lumpectomy followed by adjuvant irradiation, is now widely considered the standard of care in women with early-stage breast cancer. Accelerated partial breast irradiation (APBI), which involves focal irradiation of the lumpectomy cavity over a short period of time, has developed over the past two decades as an alternative to whole breast irradiation (WBI). Multiple APBI modalities have been developed including brachytherapy, ex...
Source: Chinese Journal of Cancer - March 27, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Clinical outcomes of EGFR-TKI treatment and genetic heterogeneity in lung adenocarcinoma patients with EGFR mutations on exons 19 and 21.
CONCLUSIONS: Patients with EGFR 19 del exhibit longer PFS and higher ORR compared with those with L858R mutations. Whether the heterogeneity of tumors with EGFR 19 del and L858R mutations contribute to a therapeutic response difference needs further investigation.
PMID: 27001083 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - March 25, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Association of HBV DNA replication with antiviral treatment outcomes in the patients with early-stage HBV-related hepatocellular carcinoma undergoing curative resection.
CONCLUSIONS: High baseline HBV DNA levels are associated with poor prognosis in the patients with early-stage HCC, and the antiviral treatment could generate survival benefits for the patients. Therefore, antiviral treatment should be given for these patients. However, the effect of antiviral treatment on the patients with low viral load remains unclear, and further investigation is warranted.
PMID: 26992891 [PubMed - as supplied by publisher] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - March 21, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Chinese Journal of Cancer reviewer acknowledgement 2015.
Authors: Xu RH, Theissen SM
PMID: 26993110 [PubMed - as supplied by publisher] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - March 21, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Meeting report on the first Sino-Dutch symposium on oncology.
Authors: Peppelenbosch MP
Abstract
On October 31, 2015, the first Sino-Dutch symposium on oncology was organized in Guangzhou (China). The symposium revealed similarities between Chinese and Dutch efforts to improve the care of tumor patients and to create enhanced insight into the nature of cancers. In particular, it became evident for some types of cancer that immunotherapy should focus on counteracting interleukin-17-associated immunity and targeting cancer stroma. Targeting specific cancer microenvironment and stroma also opens new therapeutic options, including the use of radio-active theranostics and...
Source: Chinese Journal of Cancer - March 19, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Survival and clinical outcomes in patients with metastatic epidural spinal cord compression after spinal surgery: a prospective, multicenter, observational cohort study.
CONCLUSIONS: With the alarming increase in the incidence of cancer in China and China's parallel growing cancer control efforts, China would offer a fantastic platform to set up a national metastatic spinal lesion registry. Such registry would not only enhance metastatic epidural spinal cord compression translational research but also optimize patient care.
PMID: 26984792 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - March 19, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Prospective, single-center cohort study analyzing the efficacy of complete laparoscopic resection on recurrent hepatocellular carcinoma.
CONCLUSIONS: For the patients who previously underwent conventional open surgical resection of HCC, complete laparoscopic resection was safe and effective for recurrent HCC and resulted in a shorter operation time, less intraoperative blood loss, and a faster postoperative recovery than conventional open surgery. Laparoscopic resection was especially advantageous for the patients with contralateral HCC recurrence.
PMID: 26956022 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - March 10, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Epidemiologic characteristics of oral cancer: single-center analysis of 4097 patients from the Sun Yat-sen University Cancer Center.
CONCLUSION: The incidence of oral cancer in South China presents typical characteristics to which doctors should pay attention when diagnosing and treating oral cancer patients.
PMID: 26940066 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - March 6, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
