Prognostic role of the ABO blood types in Chinese patients with curatively resected non-small cell lung cancer: a retrospective analysis of 1601 cases at a single cancer center.
CONCLUSIONS: There is an association between the ABO blood types and the survival of Chinese patients with resected NSCLC. Patients with the blood type O or B had significantly prolonged OS, DFS, and LRFS compared with those with the blood type A or AB.
PMID: 26411553 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - September 30, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Structural analysis of tumor-related single amino acid mutations in human MxA protein.
CONCLUSIONS: Among all of the reported tumor-associated single-point mutations, seven of them notably affect the structure and function of MxA and therefore deserve more attention with respect to potential clinical applications. Our research provides an example for systematic analysis and consequence evaluation of single-point mutations on a given cancer-related protein.
PMID: 26411585 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - September 30, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
miR-506: a regulator of chemo-sensitivity through suppression of the RAD51-homologous recombination axis.
Authors: Liu G, Xue F, Zhang W
Abstract
Ovarian carcinoma is the most lethal gynecologic malignancy. Resistance to platinum is considered the major problem affecting prognosis. Our recent study established that microRNA-506 (miR-506) expression was closely associated with progression-free survival and overall survival in two independent patient cohorts totaling 598 epithelial ovarian cancer cases. Further functional study demonstrated that miR-506 could augment the response to cisplatin and olaparib through targeting RAD51 and suppressing homologous recombination in a panel of ovarian cancer cell lines. Sy...
Source: Chinese Journal of Cancer - September 18, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
A multilevel pan-cancer map links gene mutations to cancer hallmarks.
CONCLUSIONS: Overlaying this map with gene mutation and focal copy number data from various cancer types makes it possible to investigate the similarities and differences between tumor samples systematically at the levels of not only genes but also pathways and hallmarks.
PMID: 26369414 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - September 18, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Stem cell-derived exosomes: roles in stromal remodeling, tumor progression, and cancer immunotherapy.
Authors: Fatima F, Nawaz M
Abstract
Stem cells are known to maintain stemness at least in part through secreted factors that promote stem-like phenotypes in resident cells. Accumulating evidence has clarified that stem cells release nano-vesicles, known as exosomes, which may serve as mediators of cell-to-cell communication and may potentially transmit stem cell phenotypes to recipient cells, facilitating stem cell maintenance, differentiation, self-renewal, and repair. It has become apparent that stem cell-derived exosomes mediate interactions among stromal elements, promote genetic instability in recipie...
Source: Chinese Journal of Cancer - September 18, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Wnt3a: functions and implications in cancer.
Authors: He S, Lu Y, Liu X, Huang X, Keller ET, Qian CN, Zhang J
Abstract
Wnt3a, one of Wnt family members, plays key roles in regulating pleiotropic cellular functions, including self-renewal, proliferation, differentiation, and motility. Accumulating evidence has suggested that Wnt3a promotes or suppresses tumor progression via the canonical Wnt signaling pathway depending on cancer type. In addition, the roles of Wnt3a signaling can be inhibited by multiple proteins or chemicals. Herein, we summarize the latest findings on Wnt3a as an important therapeutic target in cancer.
PMID: 26369691 [PubM...
Source: Chinese Journal of Cancer - September 18, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
The prognostic value of Tiam1 protein expression in head and neck squamous cell carcinoma: a retrospective study.
CONCLUSION: The Tiam1 expression is shown as a promising biomarker of clinical outcomes in patients with HNSCC and should be evaluated in prospective trials.
PMID: 26369827 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - September 18, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Brain metastasis in children with stage 4 neuroblastoma after multidisciplinary treatment.
CONCLUSIONS: High-risk factors for brain metastasis in cases of neuroblastoma include bone marrow involvement and a younger age at initial diagnosis. Nevertheless, multiple treatment modalities can improve disease-free survival.
PMID: 26370236 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - September 18, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
The updated incidences and mortalities of major cancers in China, 2011.
CONCLUSIONS: The population covered by the cancer registries greatly increased from 2010 to 2011. The data quality and representativeness of cancer registries have gradually improved. Cancer registries have an irreplaceable role in research on cancer prevention and control. The disease burden of cancer is increasing, and the health department must implement effective measures to contain the increased cancer burden in China.
PMID: 26370301 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - September 18, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Autologous peripheral blood stem cell mobilization following dose-adjusted cyclophosphamide, doxorubicin, vincristine, and prednisolone chemotherapy alone or in combination with rituximab in treating high-risk non-Hodgkin's lymphoma.
CONCLUSION: The present study demonstrated that dose-adjusted CHOP chemotherapy effectively mobilized APBSCs in NHL patients and that the addition of rituximab to dose-adjusted CHOP chemotherapy elevated the CR rate for patients with B-cell lymphoma.
PMID: 26370464 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - September 18, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Association of insulin-like growth factor-binding protein-3 with radiotherapy response and prognosis of esophageal squamous cell carcinoma.
CONCLUSIONS: High level of IGFBP-3 expression in ESCC associates with early clinical stages and are predictive for favorable survival of the patients treated with radiotherapy.
PMID: 26370590 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - September 18, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Targeted therapy: resistance and re-sensitization.
Authors: Chen DH, Zhang XS
Abstract
The last two decades have witnessed a paradigm shift from cytotoxic drugs to targeted therapy in medical oncology and pharmaceutical innovation. Inspired by breakthroughs in molecular and cellular biology, a number of novel synthesized chemical compounds and recombinant antibodies have been developed to selectively target oncogenic signaling pathways in a broad array of tumor types. Although targeted therapeutic agents show impressive clinical efficacy and minimized adverse effects compared with traditional treatments, the challenging drug-resistant issue has also emerge...
Source: Chinese Journal of Cancer - September 18, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
The reversal of antineoplastic drug resistance in cancer cells by β-elemene.
Authors: Zhang GN, Ashby CR, Zhang YK, Chen ZS, Guo H
Abstract
Multidrug resistance (MDR), defined as the resistance of cancer cells to compounds with diverse structures and mechanisms of actions, significantly limits the efficacy of antitumor drugs. A major mechanism that mediates MDR in cancer is the overexpression of adenosine triphosphate (ATP)-binding cassette transporters. These transporters bind to their respective substrates and catalyze their efflux from cancer cells, thereby lowering the intracellular concentrations of the substrates and thus attenuating or even abolishing their efficacy. In addi...
Source: Chinese Journal of Cancer - September 18, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Cytochrome b5 reductase 2 suppresses tumor formation in nasopharyngeal carcinoma by attenuating angiogenesis.
CONCLUSION: CYB5R2 up-regulates the expression of genes that negatively modulate angiogenesis in NPC cells and down-regulates the expression of VEGF to reduce angiogenesis, thereby suppressing tumor formation.
PMID: 26275421 [PubMed - as supplied by publisher] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - August 17, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Subdivision of M category for nasopharyngeal carcinoma with synchronous metastasis: time to expand the M categorization system.
CONCLUSIONS: We developed an M categorization system based on the independent factors related to the prognosis of patients with metastatic NPC. This system may be helpful to further optimize individualized care for NPC patients.
PMID: 26264052 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - August 15, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
