Molecular pathogenesis of sporadic colorectal cancers.
Authors: Yamagishi H, Kuroda H, Imai Y, Hiraishi H
Abstract
Colorectal cancer (CRC) results from the progressive accumulation of genetic and epigenetic alterations that lead to the transformation of normal colonic mucosa to adenocarcinoma. Approximately 75% of CRCs are sporadic and occur in people without genetic predisposition or family history of CRC. During the past two decades, sporadic CRCs were classified into three major groups according to frequently altered/mutated genes. These genes have been identified by linkage analyses of cancer-prone families and by individual mutation analyses of candidate ...
Source: Chinese Journal of Cancer - January 12, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Carcinogenesis of nasopharyngeal carcinoma: an alternate hypothetical mechanism.
Authors: Poh SS, Chua ML, Wee JT
Abstract
Current proposed mechanisms implicate both early and latent Epstein-Barr virus (EBV) infection in the carcinogenic cascade, whereas epidemiological studies have always associated nasopharyngeal carcinoma (NPC) with early childhood EBV infection and with chronic ear, nose, and sinus conditions. Moreover, most patients with NPC present with IgA antibody titers to EBV capsid antigen (VCA-IgA), which can precede actual tumor presentation by several years. If early childhood EBV infection indeed constitutes a key event in NPC carcinogenesis, one would have to explain th...
Source: Chinese Journal of Cancer - January 12, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Resectable left lower lobe non-small cell lung cancer with lymph node metastasis is related to unfavorable outcomes.
CONCLUSIONS: Tumor location is related to the long-term CSS of NSCLC patients with lymph node metastasis. LLL tumors may be upstaged in node-positive patients to facilitate an optimal treatment strategy.
PMID: 26738896 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - January 12, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Neoadjuvant chemotherapy plus intensity-modulated radiotherapy versus concurrent chemoradiotherapy plus adjuvant chemotherapy for the treatment of locoregionally advanced nasopharyngeal carcinoma: a retrospective controlled study.
CONCLUSIONS: The treatment outcomes of the NAC + IMRT and CCRT + AC groups were similar. Distant metastasis remained the predominant mode of treatment failure.
PMID: 26739148 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - January 12, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Differentiation therapy: a promising strategy for cancer treatment.
Authors: Yan M, Liu Q
Abstract
Poor differentiation is an important hallmark of cancer cells, and differentiation therapy holds great promise for cancer treatment. The restoration of IkB kinase α (IKKα) leads to the differentiation of nasopharyngeal carcinoma cells with reduced tumorigenicity. The findings by Yan et al. validate the polycomb protein enhancer of zeste homologue 2 (EZH2) as a target for intervention.
PMID: 26739838 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - January 12, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Phase II study of oxaliplatin combined with S-1 and leucovorin (SOL) for Chinese patients with metastatic colorectal cancer.
CONCLUSIONS: The data indicate that the SOL regimen is effective and moderately tolerated in Chinese patients with mCRC.
TRIAL REGISTRATION:
CLINICAL TRIAL INFORMATION: ChiCTR-TNRC-100000838.
PMID: 26739998 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - January 12, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Prognostic significance of the pre-chemotherapy lymphocyte-to-monocyte ratio in patients with previously untreated metastatic colorectal cancer receiving FOLFOX chemotherapy.
CONCLUSIONS: For patients with previously untreated mCRC receiving FOLFOX chemotherapy, an elevated pre-chemotherapy LMR is an independent favorable prognostic factor for PFS and OS, and changes in the LMR before and after chemotherapy seem to predict the benefit of chemotherapy.
PMID: 26740116 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - January 12, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Revisiting tumor angiogenesis: vessel co-option, vessel remodeling, and cancer cell-derived vasculature formation.
Authors: Qian CN, Tan MH, Yang JP, Cao Y
Abstract
Tumor growth and metastasis depend on the establishment of tumor vasculature to provide oxygen, nutrients, and other essential factors. The well-known vascular endothelial growth factor (VEGF) signaling is crucial for sprouting angiogenesis as well as recruitment of circulating progenitor endothelial cells to tumor vasculature, which has become therapeutic targets in clinical practice. However, the survival benefits gained from targeting VEGF signaling have been very limited, with the inevitable development of treatment resistance. In this article, we discu...
Source: Chinese Journal of Cancer - January 12, 2016 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Award for outstanding contributions to the Chinese Journal of Cancer.
Authors: Ruan J
Abstract
At the 4th Guangzhou International Symposium on Oncology, Rui-Hua Xu, Chao-Nan Qian, and Wei Zhang-the chairmen and editors of the Chinese Journal of Cancer-announced and presented awards to 14 authors in recognition of their outstanding contributions to the journal.
PMID: 26700159 [PubMed - as supplied by publisher] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - December 27, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
SHMT1 C1420T polymorphism contributes to the risk of non-Hodgkin lymphoma: evidence from 7309 patients.
CONCLUSION: SHMT1 C1420T polymorphism may be associated with NHL risk, which needs to be validated in large, prospective studies.
PMID: 26666829 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - December 20, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
A single nucleotide polymorphism in the Epstein-Barr virus genome is strongly associated with a high risk of nasopharyngeal carcinoma.
CONCLUSIONS: Our study identified an EBV variation specifically and significantly associated with a high risk of NPC. These findings provide insights into the pathogenesis of NPC and strategies for prevention.
PMID: 26675171 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - December 20, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Prognostic values of interim and post-therapy (18)F-FDG PET/CT scanning in adult patients with Burkitt's lymphoma.
CONCLUSIONS: (18)F-FDG uptake was intense in Burkitt's lymphoma, and there was a significant reduction in SUVmax during the interim and post-therapy PET/CT procedures. A ∆SUVmax of greater than 50% was a favorable cutoff point to predict the OS of Burkitt's lymphoma patients.
PMID: 26630874 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - December 5, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Estimation of cancer burden in Guangdong Province, China in 2009.
CONCLUSIONS: Cancer imposes a heavy disease burden, and cancer patterns are unevenly distributed throughout Guangdong Province. More health resources should be allocated to cancer control, especially in the western and northern mountain areas.
PMID: 26573607 [PubMed - as supplied by publisher] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - November 19, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Long-term survival trends of gastric cancer patients between 1972 and 2011 in Qidong.
CONCLUSION: The survival outcome of registered gastric cancer cases in Qidong showed gradual progress over the past two decades.
PMID: 26481511 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - October 23, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Incidence and mortality of liver cancer in China in 2011.
CONCLUSIONS: Liver cancer is a common cancer in China, particularly for males and residents in rural areas. Targeted prevention, early detection, and treatment programs should be carried out.
PMID: 26472328 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - October 18, 2015 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
