Wnt3a: functions and implications in cancer.

Wnt3a: functions and implications in cancer. Chin J Cancer. 2015 Mar;34(3):50 Authors: He S, Lu Y, Liu X, Huang X, Keller ET, Qian CN, Zhang J Abstract Wnt3a, one of Wnt family members, plays key roles in regulating pleiotropic cellular functions, including self-renewal, proliferation, differentiation, and motility. Accumulating evidence has suggested that Wnt3a promotes or suppresses tumor progression via the canonical Wnt signaling pathway depending on cancer type. In addition, the roles of Wnt3a signaling can be inhibited by multiple proteins or chemicals. Herein, we summarize the latest findings on Wnt3a as an important therapeutic target in cancer. PMID: 26369691 [PubMed - in process]
Source: Chinese Journal of Cancer - Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research