Anti-tumor activities and apoptotic mechanism of ribosome-inactivating proteins.

Anti-tumor activities and apoptotic mechanism of ribosome-inactivating proteins. Chin J Cancer. 2015;34(1):30 Authors: Zeng M, Zheng M, Lu D, Wang J, Jiang W, Sha O Abstract Ribosome-inactivating proteins (RIPs) belong to a family of enzymes that attack eukaryotic ribosomes and potently inhibit cellular protein synthesis. RIPs possess several biomedical properties, including anti-viral and anti-tumor activities. Multiple RIPs are known to inhibit tumor cell proliferation through inducing apoptosis in a variety of cancers, such as breast cancer, leukemia/lymphoma, and hepatoma. This review focuses on the anti-tumor activities of RIPs and their apoptotic effects through three closely related pathways: mitochondrial, death receptor, and endoplasmic reticulum pathways. PMID: 26184404 [PubMed - as supplied by publisher]
Source: Chinese Journal of Cancer - Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research