Abstract PP01-01: A funny thing happened to me while trying to cure ovarian cancer; I became a cancer prevention research specialist
First, I want to thank Dr. Marge Foti and the AACR Administration and Members for continuing to provide such an outstanding forum for research presentations, education and training. My AACR Membership # is 28, so you can intuit that I am as, "old as the hills." I started my working career as a summer concrete finisher in Milwaukee in 1960, earning $2.50 an hour. In May, 1962 just as was to start my 3rd "tour" on a concrete team, I received a call from my first cousin, Dr. Bruce Alberts, a Harvard biophysicist (who later in life became President of the National Academy of Science, and the Editor in Chief of the Journal, SCI...
Source: Cancer Prevention Research - October 2, 2015 Category: Cancer & Oncology Authors: Alberts, D. S. Tags: Other Topics in Behavioral and Social Science: Oral Presentations - Invited Abstracts Source Type: research
Abstract PL01-01: Meet your microbiome: An introduction to the who, what, and how of mixed microbial communities
The human microbiome is comprised of the bacteria, archaea, fungi, protists, and viruses that live in and on our bodies. It is estimated that the microbial cells that comprise your individual microbiome outnumber your own cells by a factor of 10 and that their collective gene content outnumbers your own by a factor of 100. Although scientists and physicians have appreciated the diversity of our "fellow travelers" for decades, our ability to count, study, and categorize our microbes was long limited by the challenges associated with their culture in the laboratory. The utilization of high-throughput sequencing platforms, de...
Source: Cancer Prevention Research - October 2, 2015 Category: Cancer & Oncology Authors: Hollister, E. B. Tags: Other Topics in Epidemiology/Lifestyle Factors: Oral Presentations - Invited Abstracts Source Type: research
Abstract CN01-01: Big challenges of big data: Biomedical science in the petabyte era
Next-generation sequencing technologies (NGS) have exploded in popularity in recent years thanks to their ability to produce an enormous volume of data quickly and at relatively low cost compared to traditional sequencing methods such as Sanger sequencing. The emergence of NGS has pushed forward the goal of personalized medicine, but looking at the entire scope of a study from experimental design to data analysis to the ultimate goal of dose selection based on a patient's genome reveals many more challenges. Sample size for RNA-seq studies has been a persistent problem that has only recently received attention. Sequencing ...
Source: Cancer Prevention Research - October 2, 2015 Category: Cancer & Oncology Authors: Shyr, Y. Tags: Bioinformatics and ' Omics : Oral Presentations - Invited Abstracts Source Type: research
Abstract A59: Dietary tomato and lycopene inhibition of prostate carcinogenesis in the TRAMP Model is {beta},{beta}-carotene 9',10'-oxygenase (BCO2)-dependent
Conclusions: Overall, dietary tomato and lycopene inhibited the progression of prostate cancer in TRAMP in a BCO2-dependent manner. Future human studies to examine the role of lycopene metabolism and BCO2 genotype in cancer risk reduction are warranted.Citation Format: Hsueh-Li Tan, Jennifer M. Thomas-Ahner, Nancy E. Moran, Gregory S. Young, John W. Erdman, Jr., Steven K. Clinton. Dietary tomato and lycopene inhibition of prostate carcinogenesis in the TRAMP Model is β,β-carotene 9',10'-oxygenase (BCO2)-dependent. [abstract]. In: Proceedings of the Thirteenth Annual AACR International Conference on Frontiers in C...
Source: Cancer Prevention Research - October 2, 2015 Category: Cancer & Oncology Authors: Tan, H.-L., Thomas-Ahner, J. M., Moran, N. E., Young, G. S., Erdman, J. W., Clinton, S. K. Tags: Pediatric Malignancies: Poster Presentations - Proffered Abstracts Source Type: research
Abstract A56: Metformin targets Rho GTPases to inhibit neuroblastoma cell growth; implications in the treatment of neuroblastoma
In recent years, oncologists are paying considerable attention to metformin (N', N'-dimethylbiguanide) in the treatment of various types of cancers, as some population-based studies have shown low cancer incidences and mortalities among diabetic-patients treated with metformin. In the present study, using neuroblastoma cells, we explored the anti-tumor activity and the underlying mechanisms of metformin. Neuroblastoma is a malignant cancer of the postganglionic sympathetic nervous system; it develops in the adrenal gland and metastasizes to liver, bone, bone marrow, lymph nodes, neck and chest. It is the most common cancer...
Source: Cancer Prevention Research - October 2, 2015 Category: Cancer & Oncology Authors: Kumar, A., Al-Sammarraie, N., DiPette, D. J., Singh, U. S. Tags: Pediatric Malignancies: Poster Presentations - Proffered Abstracts Source Type: research
