First evidence of pulsatile pressure interaction between the macro-vasculature and micro-vasculature: proof-of-concept by association with kidney dysfunction among patients with type 2 diabetes
Objectives: It is widely thought that excess pulsatile pressure energy from increased stiffness of large central arteries (macro-vasculature) is transmitted to capillary networks (micro-vasculature) and causes end-organ damage (i.e. kidneys). However, this hypothesis has never been tested, and we sought to achieve this by examining people with increased macro-vascular stiffness (patients with type 2 diabetes T2DM) compared with non-diabetic controls. (Source: Artery Research)
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Rachel Climie, Dean Picone, Sarah Blackwood, Ahmad Qasem, Stephen Rattigan, James Sharman Source Type: research
The relationship between diastolic function and central hemodynamics in diabetic hypertensive patients
Background: Diabetic hypertensives patients present different hemodynamic pattern than only hypertensive patients. We aimed to investigate the relationship between the diastolic function and the pulse pressure amplification (PPA), an index combining both arterial stiffness and wave reflexion, in diabetic hypertensives subjects compared to hypertensive subjects. (Source: Artery Research)
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Davide Agnoletti, Filippo Valbusa, Ari Lieber, Guido Arcaro, Michel Safar, Jacques Blacher Source Type: research
Antiplatelet and vascular effects of aspirin in healthy persons and patients with type 2 diabetes
Background: Treatment with aspirin is a cornerstone in the secondary prevention of cardiovascular disease (CVD) in diabetes, whereas its place in primary prevention remains controversial. (Source: Artery Research)
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Liv Vernstroem Hald, Anne-Mette Hvas, Erik Lerkevang Grove, Esben Laugesen, Kristian Loekke Funck, Per Loegstrup Poulsen Source Type: research
Peripheral sensory neuropathy and vascular angiogenic factors in type 2 diabetes patients in Ghana
Background: Impaired angiogenesis may be amongst the possible mechanism underlining the development of peripheral sensory neuropathy (PSN) in type 2 diabetes (T2DM) patients.(1) Angiogenesis is regulated by circulating vascular growth factor, notably, angiopoietin (Ang)-1, Ang-2 and vascular endothelial growth factor (VEGF).(2) We studied the relationship between PSN and circulating vascular growth factors, Ang-1, Ang-2 and VEGF in T2DM patients. (Source: Artery Research)
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Kwame Yeboah, Daniel A. Antwi, Ben Gyan Source Type: research
The detrimental effects of live firefighting on arterial function in firefighters
Background: Aging is associated with increased arterial stiffness and wave reflection, which is predictive of all-cause cardiovascular (CV) mortality (1-3). Firefighters have the highest cardiovascular mortality of any occupational group (4). High levels of heat stress, physical exertion, and elevated arterial stiffness (5) during/following firefighting provide a susceptible milieu for CV events. (Source: Artery Research)
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Alexander Rosenberg, Kanokwan Bunsawat, Tommy Wee, Tracy Baynard, Gavin Horn, Denise Smith, Bo Fernhall Source Type: research
Poor sleep quality related to worse vascular function in individuals with multiple sclerosis
Background: Poor sleep quality has been related to poor vascular function and higher risk of cardiovascular disease in the general population. Persons with multiple sclerosis (MS) exhibit a high cardiovascular risk, and report poor sleep quality. To date, the association between sleep quality and vascular health in MS has not been investigated. Objective: To investigate differences in vascular health between good and poor quality sleepers with MS. Methods: After a 10 minute rest in the supine position, resting heart rate (HR) and brachial blood pressure (BP) were collected.Aortic SBP, augmentation index (AIX), HR normalize...
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Thessa Hilgenkamp, Garett Griffith, Robert Motl, Tracy Baynard, Bo Fernhall Source Type: research
Assessment of blood pressure and heart rate variability in Multiple Sclerosis
Background: Reported cardiovascular autonomic dysfunction (CAD) prevalence in Multiple Sclerosis (MS) varies between studies. As CAD lowers quality of life and may contribute to sudden death in MS, early CAD detection may assist treatment and risk identification. (Source: Artery Research)
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Fatemeh Shirbani, Edward Barin, Mark Butlin, Alberto Avolio Source Type: research
Higher carotid strain in individuals with Down Syndrome at rest and during hypovolemic sympathoexcitation
Background: Arterial stiffness and large artery function are independent risk factors for cardiovascular disease.(1) Individuals with Down Syndrome (DS) have autonomic dysfunction and known to have lower incidence of cardiovascular disease.(2) Limited literatures showed no difference in arterial stiffness in DS compared to a healthy, non-DS population using a longitudinal view of the carotid artery.(3,4) However, it is unknown if individuals with DS exhibit different circumferential strain compared to individuals without DS at rest or during a sympathoexcitation stimulus. (Source: Artery Research)
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Sang Ouk Wee, Alexander Rosenberg, Bunsawat Kanokwan, Garett Griffith, Tracy Baynard, Bo Fernhall Source Type: research
Retinal vessel responses to flickering light provocation in a cohort of black and white teachers: the SABPA study
Background: Retinal microvascular function can be assessed using flicker light induced provocation (FLIP). Reduced vessel dilation responses to FLIP are noted in various disease conditions. Comparative studies between ethnic groups are scarce, while the importance of different phases of the vessel responses during and following FLIP are not well studied. We compared retinal vessel dilation, constriction and vessel diameter parameters following FLIP in a cohort of black (n=152) and white (n=178) teachers. (Source: Artery Research)
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Wayne Smith, Walthard Vilser, Konstantin Kotliar Source Type: research
The difference in glutathione peroxidase activity on arteries of a bi-ethnic population: the SABPA study
Background and objectives: From the literature it is evident that increased oxidative stress is integral in the development of cardiovascular disease. We therefore aimed to compare glutathione peroxidase (GPx) and glutathione reductase (GR) activity between black and white Africans, and to investigate whether the activity of these enzymes are linked with cardiovascular function. (Source: Artery Research)
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Johannes van Rooyen, Zurietta Schoeman, Carina Mels Source Type: research
The effect of marine n-3 polyunsaturated fatty acids on cardiac autonomic and hemodynamic function in patients with psoriatic arthritis: A randomised, double-blind, placebo-controlled trial
Background: Patients with psoriatic arthritis are at high cardiovascular risk. Marine n-3 polyunsaturated fatty acids (PUFA) may reduce the incidence of cardiovascular disease. The aim of this study was to investigate the effect of marine n-3 PUFA on cardiac autonomic function and vascular function in patients with psoriatic arthritis. (Source: Artery Research)
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Salome Kristensen, Erik Berg Schmiddt, Annette Schlemmer, Claus Rasmussen, Esther Lindgreen, Martin Berg Johansen, Jeppe Hagstrup Christensen Source Type: research
Arterial stiffness and systemic inflammation in COPD patients
Background: COPD is one of the leading causes of mortality worldwide. Systemic low-grade inflammation is a common finding in COPD. Soluble urokinase-type plasminogen activator receptor (suPAR) indicates an inflammatory state and it has an association with atherosclerosis and cardiovascular disease (CVD). ThesuPAR reflects different aspects of inflammation as high sensitive C-reactive protein (hsCRP) and IL-6. Elevated CVD risk is observed in COPD. However the correlation between COPD and arterial stiffness is rarely investigated in the literature. (Source: Artery Research)
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Renata Marietta Bocskei, Lilla Tamasi, Bela Benczur, Attila Cziraki, Gyorgy Losonczy, Aniko Bohacs Source Type: research
Carotid artery stiffness is associated with CT-measured lung air-trapping in COPD patients and controls independent of age, blood pressure and smoking history
Background: Early stages of chronic obstructive pulmonary disease (COPD) are characterized by loss of the terminal bronchioles and ‘air trapping’ often before overt emphysema manifests (1). COPD patients are also at risk for cardiovascular disease (CVD), therefore, we hypothesized that the degree of air trapping on computed tomography (CT) (2) would be associated with higher aortic (carotid femoral pulse wave velocity, CFPW V) and carotid artery stiffness (β-stiffness), biomarkers of CVD risk. (Source: Artery Research)
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Gary Pierce, John Newell, Alejandro Comellas, Eric Hoffman, Kelsey Warner, Anna Croghan, Lyndsey DuBose, Peg Nopoulos, Vince Magnotta, Stephan Arndt, Karin Hoth Source Type: research
Aortic stiffness and Body Mass Index (BMI) in Chronic Obstructive Pulmonary Disease (COPD)
Background: Patients with COPD have increased Cardiovascular (CV) risk and commonly present with altered body composition. Patients with COPD and a low BMI have poorer health outcomes1, while obesity may increase CV risk2. The aim of this analysis was to explore BMI, CV risk, exercise capacity and systemic inflammation in COPD. (Source: Artery Research)
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Nichola Gale, Ali Albarrati, Margaret Munnery, Dennis Shale, John Cockcroft Source Type: research
Arterial stiffness, blood pressure and cardiac output study
We are planning a prospective study in 200 patients with an abdominal artery aneurysm (AAA). Non-invasive measurements will be performed including tonometry-based pulse wave analysis (PWA) and pulse wave velocity (PWV), echocardiography, and 24-hour blood pressure measurements. (Source: Artery Research)
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Suzanne Holewijn, Erik Groot Jebbink, Wim Aengevaeren, Jasper Martens, Marcel Hovens, Michel Reijnen Source Type: research
