First evidence of pulsatile pressure interaction between the macro-vasculature and micro-vasculature: proof-of-concept by association with kidney dysfunction among patients with type 2 diabetes

Objectives: It is widely thought that excess pulsatile pressure energy from increased stiffness of large central arteries (macro-vasculature) is transmitted to capillary networks (micro-vasculature) and causes end-organ damage (i.e. kidneys). However, this hypothesis has never been tested, and we sought to achieve this by examining people with increased macro-vascular stiffness (patients with type 2 diabetes T2DM) compared with non-diabetic controls.

Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Rachel Climie, Dean Picone, Sarah Blackwood, Ahmad Qasem, Stephen Rattigan, James Sharman Source Type: research