The relationship between functional arterial response and circulating biomarkers of patients with fibromuscular dysplasia
Background: Fibromuscular dysplasia (FMD) is a rare idiopathic, non-atherosclerotic non-inflammatory vascular disease. This work represents the first study of the pathophysiology of FMD. We investigated the relationships between circulating biomarkers and the non-invasive vascular parameters. (Source: Artery Research)
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Thi-Phuong-Nhung Hoang, Pierre Boutouyrie, Hakim Hettab, Louise Marais, Aurelien Lorthioir, Michael Frank, Ralph Niarra, Jean-Marie Renard, Yann Chambon, Xavier Jeunemaitre, Pierre-Fran çois Plouin, Stéphane Laurent, Chantal Boulanger, Michel Azizi Source Type: research
Ventricular-arterial uncoupling does not depend on arterial elastance after myocardial infarction
Objective: Ventricular remodeling may occur following myocardial infarction (MI) of the left ventricle (LV) and such remodeling has been shown to be correlated with increased patient morbidity and mortality. It is important to estimate the likelihood of remodeling from the state of the infarcted LV. The aim of the study was to assess the ventricular-arterial coupling (VAC) in patients with ST segment elevation (STEMI) and non ST segment elevation MI (NSTEMI) treated with percutaneous coronary intervention (PCI). (Source: Artery Research)
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Elena Zharikova, Svetlana Villevalde, Zhanna Kobalava Source Type: research
Ventricular arterial coupling in isometric handgrip test in untreated hypertensive patients
Aim: To evaluate cardiovascular adaptation to increased afterload during handgrip isometric exercise (HIE) in untreated hypertensive patients. (Source: Artery Research)
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Anna Bogomaz, Yulia Kotovskaya, Zhanna Kobalava Source Type: research
Reduced ventricular-arterial coupling as an early marker of cardiovascular remodeling in hypertensive men
Objective: To evaluate ventricular-arterial coupling (VAC), left ventricular hypertrophy (LVH), diastolic function and arterial stiffness in young and middle-aged men with uncomplicated arterial hypertension (Source: Artery Research)
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Anna Bogomaz, Yulia Kotovskaya, Zhanna Kobalava Source Type: research
Sarcopenia and vascular risk in a healthy elderly UK population (BRAVES Study)
Introduction: Sarcopenia, the loss of skeletal muscle mass and strength that occurs with advancing age [1] is correlated with functional decline and disability but little is known about its relationship with cardiovascular risk. Bioimpedence analysis (BIA) is a validated technique for measuring muscle mass, convenient for use in large cohort studies. Arterial stiffness (compliance) is an independent predictor of cardiovascular events. (Source: Artery Research)
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: A. Nagy, I. Ramsay, J. Wright, C. Morrison, C. Bulpitt, F. Fantin, M. Zamboni, C. Rajkumar Source Type: research
The effects of alpha 1-adrenoceptor-blockade and angiotensin converting enzyme-inhibition on indices of aortic stiffness measured by an oscillometric single cuff method in hypertension: the doxazosin ramipril study
Objectives: To study whether inhibition of the renin-angiotensin-aldosterone system has effects on arterial stiffness beyond blood pressure (BP) reduction alone. (Source: Artery Research)
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Andreas Jekell, Majid Kalani, Thomas Kahan Source Type: research
Effects on vascular structure and function of single at1r blockade or its combination with CCB, diuretics or their triple association
Environment/Objectives: The antihypertensive efficacy of Valsartan (VAL) is largely known in monotherapy and combination with CCB and diuretics (D) but there is scarce evidence of its vascular effects in subjects younger than 60 y.o. Otherwise, there is a rationale supporting using combinations in high CV risk or patients with higher BP but vascular findings are not considered still as a reason. (Source: Artery Research)
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Pedro Forcada, Carlos Castellaro, Jorge Chiabaut, Sergio Gonzalez, Carol Kotliar, Sebastian Obregon Source Type: research
Sacubitril/valsartan therapy is associated with decrease of arterial elastance in stable patients with heart failure with reduced ejection fraction
Objective: Angiotensin receptor-neprilysin inhibition with LCZ696 is a novel approach for the treatment of heart failure with reduced ejection fraction (HFrEF). The aim of the study was to assess the effects of valsartan/sacubitril on parameters of ventricular-arterial coupling and left ventricular (LV) work efficiency in patients with stable HFrEF. (Source: Artery Research)
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Zhanna Kobalava, Svetlana Villevalde, Olga Lukina, Evgenii Tyukhmenev Source Type: research
Sacubitril/valsartan therapy is associated with decrease of pulse wave velocity in stable patients with heart failure with reduced ejection fraction
Objective: Dual neprilysin inhibition and angiotensin receptor blockade with LCZ696 has been shown therapeutic benefits in chronic heart failure (CHF) patients. The aim of the study was to assess sacubitril/valsartan effects on parameters of arterial stiffness in stable heart failure with reduced ejection fraction (HFrEF). (Source: Artery Research)
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Zhanna Kobalava, Svetlana Villevalde, Olga Lukina Source Type: research
Ventricular-arterial coupling during treatment with bisoprolol and bisiprolol/amlodipin in hypertensive patients
Objective: To evaluate ventricular-arterial coupling in hypertensive patients after therapy with a beta-blocker and its fixed dose combination (FDC) with amlodipine. (Source: Artery Research)
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Anna Bogomaz, Yulia Kotovskaya, Zhanna Kobalava Source Type: research
Switching to bisoprolol/amlodipine fdc eliminates adverse effect of a beta-blocker on aortic pulse pressure augmentation
Objective: The aim of the study was to evaluate if combination with amlodipine eliminates the adverse effect of beta-blockers on aortic pulse pressure (PP) augmentation. (Source: Artery Research)
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Anna Bogomaz, Yulia Kotovskaya, Zhanna Kobalava Source Type: research
Ventriculo-vascular interactions and the arterial Windkessel: new insights from cardiovascular magnetic resonance imaging before and after renal denervation
We present the feasibility of both methods. (Source: Artery Research)
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Giovanni Biglino, Amy Burchell, Jonathan Rodrigues, Robert D.M. Gray, Emma C. Hart, Julian F.R. Paton, Nathan E. Manghat, Andreas Baumbach, Angus K. Nightingale Source Type: research
The effect of rosuvastatin added to a standard antihypertensive therapy on arterial stiffness in patients with uncontrolled hypertension
We studied the influence of rosuvastatin added to a standard therapy on central BP and pulse wave velocity (PWV) in patients with uncontrolled hypertension. 60 patients (31 men and 29 women aged 51.19.1) with uncontrolled hypertension were randomized into two groups. Group 1 included 30 patients who received a fixed combination of 10 mg/day lisinopril and 5 mg/day amlodipine (Ekvator ®, Richter Gedeon, Hungary). Group 2 consisted of 30 patients who followed the same regimen of therapy with addition of 20 mg/day of rosuvastatin. (Source: Artery Research)
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Anna Torunova Source Type: research
Impact of the glycemic control status on the 2-year progression of the arterial stiffness in add-on a dipeptidyl peptidase 4 inhibitor treatment
Aims: The effect of sitagliptin on the 2-year progression of the arterial stiffness and also to determine the effect of good glycemic control on the rate of progression of the arterial stiffness was examined. (Source: Artery Research)
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Hirofumi Tomiyama, Koichi Node, Akira Yamashina Source Type: research
Effects of dapagliflozin on early alterations of the micro- and macrocirculation
Background: Diabetes mellitus, primarily a metabolic disorder, must be considered also as a vascular disease. Early vascular changes are characterized by hyperperfusion (e.g. eye), vascular remodeling of small arteries and increased pulse wave reflection leading to increased (central) aortic pressure. We investigated the effects of the SGLT-2 inhibitor dapagliflozin on parameters of early micro- and macrovascular changes in patients with type-2 diabetes. (Source: Artery Research)
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Christian Ott, Iris Kistner, Agnes Jumar, Stephanie Friedrich, Peter Bramlage, Roland Schmieder Source Type: research
