Higher carotid strain in individuals with Down Syndrome at rest and during hypovolemic sympathoexcitation

Background: Arterial stiffness and large artery function are independent risk factors for cardiovascular disease.(1) Individuals with Down Syndrome (DS) have autonomic dysfunction and known to have lower incidence of cardiovascular disease.(2) Limited literatures showed no difference in arterial stiffness in DS compared to a healthy, non-DS population using a longitudinal view of the carotid artery.(3,4) However, it is unknown if individuals with DS exhibit different circumferential strain compared to individuals without DS at rest or during a sympathoexcitation stimulus.

Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Sang Ouk Wee, Alexander Rosenberg, Bunsawat Kanokwan, Garett Griffith, Tracy Baynard, Bo Fernhall Source Type: research