The Impact of Hypoglycemia on the Cardiovascular System: Physiology and Pathophysiology
Intensive glycemic control may increase cardiovascular (CV) risk and mortality due to hypoglycemia. The pathophysiology of glucose counter-regulation in patients with type 1 or type 2 diabetes for over 15 years is characterized by impairment of the defense mechanisms against hypoglycemia. Hypoglycemia causes pronounced physiological and pathophysiological effects on the CV system as consequences of autonomic system activation and counter regulatory hormones release. These effects provoke a series of hemodynamic changes that include an increase in heart rate and peripheral systolic blood pressure, a decrease in central bloo...
Source: Angiology - September 15, 2016 Category: Cardiology Authors: Yang, S.-W., Park, K.-H., Zhou, Y.-J. Tags: Reviews Source Type: research
Short-Term Prognosis of Juvenile Myocardial Infarction: Role of Plasma Viscosity
(Source: Angiology)
Source: Angiology - September 15, 2016 Category: Cardiology Authors: Caimi, G., Lo Presti, R., Andolina, G., Hopps, E. Tags: Editorials Source Type: research
"Summer Dizziness" as a Neglected Phenomenon of Antihypertensive Drug Overuse in Patients With Carotid Disease: A Hypothesis
(Source: Angiology)
Source: Angiology - September 15, 2016 Category: Cardiology Authors: Radak, D., Tanaskovic, S. Tags: Editorials Source Type: research
Critical Issues and Controversies in Carotid Artery Stenosis: False Knowledge Is More Dangerous Than Ignorance
(Source: Angiology)
Source: Angiology - August 18, 2016 Category: Cardiology Authors: Paraskevas, K. I., Mikhailidis, D. P., Veith, F. J. Tags: Response Letter Source Type: research
Current Debates on the Treatment of Carotid Stenosis in Both Symptomatic and Asymptomatic Patients: A Reappraisal
(Source: Angiology)
Source: Angiology - August 18, 2016 Category: Cardiology Authors: Moris, D., Bakoyiannis, C., Kakkos, S. Tags: Letter to the Editor Source Type: research
Safe Exclusion of Deep Vein Thrombosis by a Rapid Sensitive ELISA D-dimer and Compression Ultrasonography in 1330 Outpatients With Suspected DVT
Of 1330 outpatients with suspected deep vein thrombosis (DVT), a normal enzyme-linked immunosorbent assay (ELISA) d-dimer (VIDAS) of <500 ng/mL was true negative in 382 of 384 and false negative in compression ultrasonography (CUS) in 2, indicating a sensitivity of 99.52% and a negative predictive value (NPV) of 99.48%, with a specificity of 36% irrespective of clinical score. In 1059 outpatients with no DVT, the CUS was positive for the alternative diagnoses (AD): Bakers cyst, muscle hematoma, or old DVT in 62 (5.8%); superficial vein thrombosis without DVT in 78 (7.4%), and leg edema or varices in 17%. A second CUS in...
Source: Angiology - August 18, 2016 Category: Cardiology Authors: Michiels, J. J., Maasland, H., Moossdorff, W., Lao, M., Gadiseur, A., Schroyens, W. Tags: Deep Vein Thrombosis Source Type: research
Structured Home-Based Exercise Versus Invasive Treatment: A Mission Impossible? A Pilot Randomized Study in Elderly Patients With Intermittent Claudication
We compared the effects of an original structured home-based exercise program and revascularization in elderly patients with peripheral arterial disease over a 4-month period. Twenty-seven participants (n = 21; age = 68 ± 7 years) with moderate to severe claudication were randomized into (1) a test in–train out group (Ti-To; n = 18) that performed a home-based walking program prescribed and controlled at the hospital or (2) a revascularization group (Rev; n = 9) that underwent an endovascular and/or surgical procedure. The primary end point was quality of life as evaluated by the physical component summary (PC...
Source: Angiology - August 18, 2016 Category: Cardiology Authors: Lamberti, N., Malagoni, A. M., Ficarra, V., Basaglia, N., Manfredini, R., Zamboni, P., Mascoli, F., Manfredini, F. Tags: Peripheral Artery Disease Source Type: research
Association of {beta}-Adrenergic Receptor Gene Polymorphisms With Acute Coronary Syndrome and Cardiovascular Risk Factors in an Arab Population
We evaluated the association between beta-adrenergic receptor genes (ADRB1 and ADRB2) polymorphism, cardiovascular risk, and acute coronary syndrome (ACS) in individuals from an Arab ethnicity. A total of 388 Qatari participants were assessed and genotyped for ADRB1 (rs1801252 & rs1801253) and ADRB2 (rs1042718 & rs1042713) polymorphisms using allele-specific PCR. Minor allele frequencies (MAF) in each single-nucleotide polymorphisms (SNPs) did not show statistically significant difference between cases and controls. A higher proportion of patients with ACS had homozygous minor alleles (GG) for rs1801253 (28.8% vs 1...
Source: Angiology - August 18, 2016 Category: Cardiology Authors: El-Menyar, A., Rizk, N. M., Asim, M., Al-Thani, H., Elgendy, A., Al-Suwaidi, J. Tags: Coronary Heart Disease Source Type: research
Predictors of Prolonged In-Hospital Stay After Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction
In this study, we aimed to determine the differences between long-stay and early discharged patients with STEMI. For this retrospective study, a total of 2486 consecutive patients with STEMI (mean age: 56.2 ± 11.7 years, 16.5% female) who had undergone primary percutaneous coronary intervention (pPCI) were enrolled. Patients were divided into 2 groups based on mean in-hospital stay: <6 days and ≥6 days. Anterior STEMI (odds ratio [OR]: 1.61, 95% confidence interval [CI]: 1.02-2.54; P = 0.03), angiographic failure (OR: 2.89, 95% CI: 1.19-7.01; P = .01), and peripheral vascular complications (PVCs; OR: 4.18, 95%...
Source: Angiology - August 18, 2016 Category: Cardiology Authors: Isik, T., Ayhan, E., Uluganyan, M., Gunaydin, Z. Y., Uyarel, H. Tags: Coronary Heart Disease Source Type: research
Endocan Levels and Subclinical Atherosclerosis in Patients With Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of unknown etiology. A major cause of morbidity and mortality in SLE is accelerated atherosclerosis. Endothelial-specific molecule 1 (endocan) is a potential predictor of vascular events and is expressed in response to inflammatory cytokines in endothelial cells. We investigated the relationship between endocan and carotid intima–media thickness (cIMT) as a marker of early atherosclerosis. We included 44 women with SLE and 44 healthy women as controls. Disease severity of SLE was evaluated using the SLE Disease Activity Index. Endocan, C-reactive prot...
Source: Angiology - August 18, 2016 Category: Cardiology Authors: Icli, A., Cure, E., Cure, M. C., Uslu, A. U., Balta, S., Mikhailidis, D. P., Ozturk, C., Arslan, S., Sakız, D., Sahin, M., Kucuk, A. Tags: Inflammation and Vascular Disease Source Type: research
The Impact of Routine Angiographic Follow-Up in a Population of Patients Undergoing Percutaneous Coronary Intervention Within the Left Main Coronary Artery
Prognostic value of angiographic follow-up in patients undergoing percutaneous coronary interventions (PCIs) of the left main coronary artery (LMCA) still remains uncertain. The aim of the study was to compare clinical characteristics, mortality, and major cardiovascular events in patients with versus without angiographic follow-up after PCI of the LMCA as well as to identify independent risk factors for death after PCI of the LMCA. Study population consisted of 217 patients of 290 consecutive participants who underwent PCI of the LMCA and subsequently were divided into 2 groups: angiographic follow-up group (angio FU grou...
Source: Angiology - August 18, 2016 Category: Cardiology Authors: Mencel, G., Kowalczyk, J., Lenarczyk, R., Chodor, P., Was, T., Swierad, M., Honisz, G., Swiatkowski, A., Wozniak, A., Kalarus, Z., Sredniawa, B. Tags: Coronary Heart Disease Source Type: research
Utility of {gamma}-Glutamyl Transferase in Predicting Troponin Elevation in Emergency Departments
Serum -glutamyl transferase (GGT) activity is a risk predictor for the development of coronary artery disease and is related to cardiovascular morbidity and mortality. We evaluated the clinical utility of GGT activity in predicting high troponin levels in patients with acute coronary syndrome (ACS) admitted to the emergency department with chest pain. A total of 200 troponin-positive and 203 troponin-negative patients were classified into groups 1 and 2, respectively. -Glutamyl transferase activity was significantly higher in group 1 (44 ± 34 U/L) compared with group 2 (31 ± 26 U/L, P = .001). A GGT activity ...
Source: Angiology - August 18, 2016 Category: Cardiology Authors: Demirelli, S., Firtina, S., Askin, L., Akgol Gur, S. T., Tanrikulu, C. S., Ermis, E., Ipek, E., Kalkan, K., Yildirim, E., Kiziltunc, A. Tags: Coronary Heart Disease Source Type: research
Serum Potassium Levels and Short-Term Outcomes in Patients With ST-Segment Elevation Myocardial Infarction
Current guidelines recommend maintaining serum potassium levels between 4.0 and 5.0 mEq/L (1 mEq/L = mmol/L) in patients with acute myocardial infarction. However, these guidelines are based on studies conducted before the β blocker and reperfusion era. We retrospectively analyzed 6613 patients diagnosed with ST-segment elevation myocardial infarction (STEMI) who presented without renal insufficiency. Patients were categorized into 5 groups according to mean serum potassium levels: <3.5, 3.5 to <4.0, 4.0 to <4.5, 4.5 to <5.0, and ≥5.0 mEq/L. Patients with potassium levels of 4.0 to <4.5 mEq/L had the...
Source: Angiology - August 18, 2016 Category: Cardiology Authors: Ma, W., Liang, Y., Zhu, J., Yang, Y., Tan, H., Yu, L., Gao, X., Feng, G., Li, J. Tags: Coronary Heart Disease Source Type: research
MyoK+ardial Infarction: Potassium Levels and Outcomes Following Acute Myocardial Infarction
(Source: Angiology)
Source: Angiology - August 18, 2016 Category: Cardiology Authors: Shiyovich, A., Plakht, Y. Tags: Editorial Source Type: research
Venous Thromboembolism in Patients Diagnosed With Lung Cancer
Conclusions:
Efforts to assess thrombotic risk in patients with lung cancer may improve therapeutic and preventive strategies in the future, with final goal to minimize the burden and consequences of thrombotic events in patients with lung cancer. (Source: Angiology)
Source: Angiology - August 18, 2016 Category: Cardiology Authors: Salla, E., Dimakakos, E. P., Tsagkouli, S., Giozos, I., Charpidou, A., Kainis, E., Syrigos, K. N. Tags: Review Source Type: research
