Nutraceuticals in Lipid-Lowering Treatment: A Narrative Review on the Role of Chitosan
Lipid-lowering drugs may cause adverse effects and, although lipid targets may be achieved, a substantial residual cardiovascular (CV) risk remains. Treatment with agents mimicking proteins present in the body, such as incretin-based therapies, provided promising results. However, in order to improve lipids and CV risk, lifestyle measures remain important. Some researchers focused on nutraceuticals that may beneficially affect metabolic parameters and minimize CV risk. Chitosan, a dietary fiber, can regulate lipids with benefit on anthropometric parameters. The beneficial properties of dietary supplements (such as green te...
Source: Angiology - April 15, 2015 Category: Cardiology Authors: Patti, A. M., Katsiki, N., Nikolic, D., Al-Rasadi, K., Rizzo, M. Tags: Reviews Source Type: research
South Asian Ethnicity and Cardiovascular Risk: The Known, the Unknown, and the Paradox
South Asians (SAs), in their countries or after migration, are at high risk of coronary artery disease (CAD) and mortality compared to other ethnic groups. It has been shown that >90% of CAD global risk could be attributed to 9 modifiable risk factors (RFs) worldwide. However, these conventional RFs may not fully explain this high risk of CAD among SAs. Therefore, attention has been directed toward nonconventional RFs. In this narrative review, we evaluate the conventional and emerging cardiovascular RFs characterizing SAs. These factors may explain the high morbidity and mortality among SAs. Further prospective studies...
Source: Angiology - April 15, 2015 Category: Cardiology Authors: Ahmed, E., El-Menyar, A. Tags: Reviews Source Type: research
Methylenetetrahydrofolate Reductase C677T Polymorphism, Venous Thrombosis, Cardiovascular Risk, and Other Effects
(Source: Angiology)
Source: Angiology - April 15, 2015 Category: Cardiology Authors: Whayne, T. F. Tags: Editorial Source Type: research
Mean Platelet Volume in Chronic Urticaria and Beyond
(Source: Angiology)
Source: Angiology - April 9, 2015 Category: Cardiology Authors: Gurdol, F., Isıksacan, N., Koser, M. Tags: Response Letter Source Type: research
Confounding Factors May Affect Mean Platelet Volume in Chronic Urticaria
(Source: Angiology)
Source: Angiology - April 9, 2015 Category: Cardiology Authors: Varol, E. Tags: Letter Source Type: research
Platelet and Other Hemostatic Characteristics in Patients With Chronic Urticaria
Several publications have pointed out the importance of coagulation and fibrinolysis in the occurrence of chronic urticaria (CU), but only a few indicated the direct role of platelets. We assessed platelet aggregation and evaluated parameters of coagulation and fibrinolysis in patients with CU. Patients (n = 34) diagnosed as having CU and 36 healthy controls were enrolled. Platelet aggregation was assayed using an impedance aggregometer and adenosine diphosphate, arachidonic acid, thrombin receptor-activating peptide (TRAP), and ristocetin as agonists. In patients with CU, significantly decreased platelet aggregation to so...
Source: Angiology - April 9, 2015 Category: Cardiology Authors: Isiksacan, N., Koser, M., Cemsitoglu, F., Kucuksezer, U. C., Gurdol, F. Tags: Thrombosis Source Type: research
Time Course and the Recanalization Rate of Superficial Vein Thrombosis Treated With Low-Molecular-Weight Heparin
The aim of this study was to follow the thrombus progression and regression in superficial veins of lower limbs in patients with superficial vein thrombosis (SVT) treated with low-molecular-weight heparin. Patients (n = 68) with a first symptomatic SVT of the lower limbs received 2 different dosages of dalteparin. The primary outcome was a change in the diameter and length of thrombus in the affected veins. The regression of thrombus was not significantly different between the groups (P = .19). The reduction in the length of thrombus as well as thrombus diameter was significantly greater in females. At the end of the obser...
Source: Angiology - April 9, 2015 Category: Cardiology Authors: Spirkoska, A., Jezovnik, M. K., Poredos, P. Tags: Thrombosis Source Type: research
Evaluation of Platelet Distribution Width and Mean Platelet Volume in Patients With Carotid Artery Stenosis: Author's Reply
(Source: Angiology)
Source: Angiology - April 9, 2015 Category: Cardiology Authors: Adam, G., Kocak, E., Reşorlu, M. Tags: Response Letter Source Type: research
Platelet Indices in Patients With Carotid Artery Stenosis
(Source: Angiology)
Source: Angiology - April 9, 2015 Category: Cardiology Authors: Akin, F., Altun, I., Ayca, B. Tags: Letter Source Type: research
Evaluation of Platelet Distribution Width and Mean Platelet Volume in Patients With Carotid Artery Stenosis
This study showed that PDW, not MPV, is related to the degree of CS. Platelet distribution width could be a useful biomarker for CS. Whether targeting PDW will be of clinical benefit remains to be established. (Source: Angiology)
Source: Angiology - April 9, 2015 Category: Cardiology Authors: Adam, G., Kocak, E., Ozkan, A., Reşorlu, M., Cınar, C., Bozkaya, H., Kurt, T., Altun, B., Şen, H. M., Akbal, A., Bozkurt, N., Sacar, M. Tags: Carotid disease Source Type: research
Reliability of the Vascular Claudication Reporting in Diabetic Patients With Peripheral Arterial Disease: A Study With Near-Infrared Spectroscopy
We evaluated whether altered reporting of ischemic symptoms occurs in diabetic patients with peripheral arterial disease (PAD) and stable claudication. Patients (n = 152) with claudication were enrolled (120 males; mean age: 71.0 ± 8.6 years): 74 with diabetes (DM-PAD) and 78 without (DMfree-PAD). The degree of muscle oxygenation at symptom onset and maximal speed (Smax) during an incremental treadmill test was recorded at the gastrocnemius by near-infrared spectroscopy (NIRS) and quantified by area under the curve of oxygenated hemoglobin (AUC-Hbo 2) and area under the curve of differential hemoglob...
Source: Angiology - April 9, 2015 Category: Cardiology Authors: Manfredini, F., Lamberti, N., Malagoni, A. M., Zambon, C., Basaglia, N., Mascoli, F., Manfredini, R., Zamboni, P. Tags: Abdominal Aortic Aneurysm Source Type: research
Prevalence and Severity of Asymptomatic Coronary and Carotid Artery Disease in Patients With Abdominal Aortic Aneurysm
We evaluated the prevalence and severity of occult coronary artery disease (CAD) and cerebrovascular disease (CeVD) in patients with abdominal aortic aneurysm (AAA). We studied 100 consecutive patients with no history of CAD, normal electrocardiogram, normal systolic function, and no angina or dyspnea. All patients underwent carotid Doppler study and invasive coronary angiography. Significant CAD was observed in 61% of patients. In all, 51% of patients with significant CAD showed either left main (n = 7), 3-vessel (n = 17), or proximal left anterior descending (n = 7) CAD, corresponding to 31% of the total cohort. Cerebrov...
Source: Angiology - April 9, 2015 Category: Cardiology Authors: Marsico, F., Giugliano, G., Ruggiero, D., Parente, A., Paolillo, S., Guercio, L. D., Esposito, G., Trimarco, B., Filardi, P. P. Tags: Abdominal Aortic Aneurysm Source Type: research
Clot Strength is Negatively Associated With Ambulatory Function in Patients With Peripheral Artery Disease and Intermittent Claudication
In conclusion, clot strength and platelet aggregation correlated with objective and self-perceived ambulatory measures. Patients with PAD having more severe walking impairment may be likely to form stronger clots. (Source: Angiology)
Source: Angiology - April 9, 2015 Category: Cardiology Authors: Mauer, K., Gardner, A. W., Dasari, T. W., Stoner, J. A., Blevins, S. M., Montgomery, P. S., Saucedo, J. F., Exaire, J. E. Tags: Peripheral Artery Disease Source Type: research
Lipid Target Achievement Among Patients With Very High and High Cardiovascular Risk in a Lipid Clinic
This was a retrospective study that assessed achievement of lipid-lowering treatment targets in the setting of a University Hospital Lipid Clinic. Low-density lipoprotein cholesterol (LDL-C) goal attainment according to National Cholesterol Education Program-Adult Treatment Panel III (NCEP ATP III) and European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) guidelines was recorded in 1000 consecutive adult patients followed for ≥3 years (mean 8 years). The LDL-C targets according to the NCEP ATP III were attained by 66% and 86% of patients with "very high" (n = 477) and "high" (n = 408) cardiovascular ...
Source: Angiology - April 9, 2015 Category: Cardiology Authors: Barkas, F., Liberopoulos, E. N., Kostapanos, M. S., Liamis, G., Tziallas, D., Elisaf, M. Tags: Lipids Source Type: research
Oxidative Stress and Paraoxonase 1 Activity Predict Contrast-Induced Nephropathy in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Reactive oxygen species have been implicated in the pathogenesis of contrast-induced nephropathy (CIN). We investigated the relationship between CIN with paraoxonase 1 (PON-1) activity and oxidative stress markers (total antioxidant status [TAS], total oxidant status [TOS], and oxidative stress index [OSI]) in patients with anterior ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention; 289 consecutive patients with STEMI were prospectively included. The patients were divided into 2 groups: CIN (n = 69) and non-CIN (n = 220). Activity of PON-1 and TAS levels were significa...
Source: Angiology - April 9, 2015 Category: Cardiology Authors: Borekci, A., Gur, M., Turkoğlu, C., Caylı, M., Selek, Şahbettin, Kaypaklı, O., Ucar, H., Coşkun, M., Şeker, T., Koc, M., Gokdeniz, T., Gozukara, M. Y. Tags: Contrast-Induced Nephropathy Source Type: research
