Uric Acid and Peripheral Arterial Disease
(Source: Angiology)
Source: Angiology - July 24, 2015 Category: Cardiology Authors: Zhan, Y., Dong, Y., Yu, J. Tags: Response Letter Source Type: research
Importance of Uric Acid Levels and Comorbidities Affecting Renal Function
(Source: Angiology)
Source: Angiology - July 24, 2015 Category: Cardiology Authors: Sertoglu, E., Uyanik, M. Tags: Letter Source Type: research
Serum Uric Acid, Gender, and Low Ankle Brachial Index in Adults With High Cardiovascular Risk
Uric acid (UA) has been reported to be associated with cardiovascular disease (CVD) in caucasians. However, it is unclear whether this association remains significant in a Chinese population. The present study aimed to investigate the association between UA and low ankle brachial index (ABI), a measurement of peripheral arterial disease, in Chinese patients. A total of 6262 hospital-based patients with high CVD risk were enrolled. Low ABI was defined as ABI ≤0.9 in either side. Low ABI was detected in 1390 (22.2%) patients. Higher UA was significantly associated with higher risk of low ABI and modified by gender (P = .0...
Source: Angiology - July 24, 2015 Category: Cardiology Authors: Zhan, Y., Dong, Y., Tang, Z., Zhang, F., Hu, D., Yu, J. Tags: Peripheral Artery Diseases Source Type: research
Vascular Reactivity Is Impaired and Associated With Walking Ability in Patients With Intermittent Claudication
We verified whether vascular reactivity is impaired and whether there is any association between vascular reactivity, walking ability, and peripheral artery disease (PAD) severity in patients with intermittent claudication (IC). We studied 63 patients and 17 age- and sex-matched volunteers without PAD. Vascular reactivity was evaluated in the brachial artery during reactive hyperemia (flow-mediated dilation [FMD]) and after a sublingual single dose of nitroglycerin (nitroglycerin-induced vasodilation [NID]). Walking ability was verified by a 6-minute walk test. Vascular reactivity and walking ability were significantly wor...
Source: Angiology - July 24, 2015 Category: Cardiology Authors: Silva, R. d. C. G. e., Wolosker, N., Yugar-Toledo, J. C., Consolim-Colombo, F. M. Tags: Peripheral Artery Diseases Source Type: research
Arterial Plaques in Peripheral Arteries Diagnosed by Ultrasound in a Cohort of Patients With Type 2 Diabetes Mellitus: A Single-Center Surveillance
In conclusion, Aplqs of lower limbs are frequent in T2DM and several factors can play a determining role. Ultrasound is a helpful diagnostic tool. (Source: Angiology)
Source: Angiology - July 24, 2015 Category: Cardiology Authors: Signorelli, S. S., Fiore, V., Mangiafico, M., Castrogiovanni, D. Tags: Peripheral Artery Diseases Source Type: research
Serum Gamma-glutamyltransferase Levels Predict the Progression of Coronary Artery Calcification in Adults With Type 2 Diabetes Mellitus
Progression of coronary artery calcification (CAC) may be more predictive of future coronary heart disease events than a baseline CAC score. We determined whether serum gamma-glutamyltransferase (GGT) activity can independently predict the progression of CAC in adults with type 2 diabetes mellitus (T2DM). Patients (n = 326) without symptomatic cardiovascular (CV) disease were evaluated by CAC imaging. The CAC scores were assessed at baseline and after 20 ± 4 months. Serum GGT activities were significantly higher in progressors compared with nonprogressors (39 ± 16 vs 27 ± 11 U/L, P < .001). Multivar...
Source: Angiology - July 24, 2015 Category: Cardiology Authors: Gang, L., Wei-Hua, L., Rong, A., Jian-Hong, Y., Zi-Hua, Z., Zhong-Zhi, T. Tags: Coronary Artery Diseases Source Type: research
Is Mitral Annular Calcification Associated With Atherosclerotic Risk Factors and Severity and Complexity of Coronary Artery Disease?
We assessed the association of mitral annular calcification (MAC) with atherosclerotic risk factors and severity and complexity of coronary artery disease (CAD). Cardiac catheterization reports and electronic medical records from 2010 to 2011 were retrospectively reviewed. A total of 481 patients were divided into 2 groups: MAC present (209) and MAC absent (272). All major cardiovascular risk factors, comorbidities, and coronary lesion characteristics were included. On linear regression analysis, age (P = .001, β 1.12) and female gender (P = .031, β 0.50) were the independent predictors of MAC. Mitral annular cal...
Source: Angiology - July 24, 2015 Category: Cardiology Authors: Bhatt, H., Sanghani, D., Julliard, K., Fernaine, G. Tags: Coronary Artery Diseases Source Type: research
Association of 5 Well-Defined Polymorphisms in the Gene Encoding Transforming Growth Factor-{beta}1 With Coronary Artery Disease Among Chinese Patients With Hypertension
We assessed the association between 5 well-defined polymorphisms of the transforming growth factor-β1 (TGFB1) gene and coronary artery disease (CAD) among patients with hypertension from northeast China. All study participants were classified into patients with CAD (n = 679) and controls (n = 686) according to angiographic results. Genotyping was carried out with the ligase detection reaction method. In single-locus analysis, only genotypes of rs1800469 differed significantly between patients with CAD and controls (P = .001); patients carrying the mutant allele of rs1800469 exhibited a 73% increased risk of CAD (P <...
Source: Angiology - July 24, 2015 Category: Cardiology Authors: Xu, J., Yu, X., Huang, C., Qin, R., Peng, F., Lin, J., Niu, W. Tags: Coronary Artery Diseases Source Type: research
Mild to Moderate Renal Impairment Is Associated With No-Reflow Phenomenon After Primary Percutaneous Coronary Intervention in Acute Myocardial Infarction
We investigated whether admission estimated glomerular filtration rate (eGFR) values are associated with no-reflow phenomenon in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI). Patients (n = 673; 59 ± 13 years; 77.1% men) were stratified into 3 groups according to eGFR at admission: normal renal function (eGFR ≥ 90 mL/min/1.73 m2), mild renal impairment (eGFR 60-89 mL/min/1.73 m2), and moderate renal impairment (eGFR 30-59 mL/min/1.73 m2). No-reflow phenomenon was defined as thrombolysis in myocardial infarction flow grade <3 afte...
Source: Angiology - July 24, 2015 Category: Cardiology Authors: Kurtul, A., Murat, S. N., Yarlioglues, M., Duran, M., Celik, I. E., Kilic, A. Tags: Coronary Artery Diseases Source Type: research
Increased Platelet Distribution Width Is Associated With Severity of Coronary Artery Disease in Patients With Acute Coronary Syndrome
Platelet activation plays a pivotal role in acute coronary syndrome (ACS). We investigated the relationship between platelet distribution width (PDW) and severity of coronary artery disease (CAD) in patients with ACS. A total of 502 patients with ACS were enrolled. High (n = 151) and low PDW (n = 351) groups were defined as patients having values in the third tertile (>17%) and lower 2 tertiles (≤17%). There were significantly higher Gensini score (44 [10-168] vs 36 [2-132], P < .001), and neutrophil–lymphocyte ratio (3.1 [0.8-12.4] vs 2.5 [0.3-13], P = .012) and baseline platelet counts were significantly l...
Source: Angiology - July 24, 2015 Category: Cardiology Authors: Bekler, A., Ozkan, M. T. A., Tenekecioglu, E., Gazi, E., Yener, A. U., Temiz, A., Altun, B., Barutcu, A., Erbag, G., Binnetoglu, E. Tags: Coronary Artery Diseases Source Type: research
Circulating Endothelial Cells and Platelet Microparticles in Mitral Valve Disease With and Without Atrial Fibrillation
Hypercoagulability in mitral valve disease (MVD), a cause of atrial fibrillation (AF) and stroke, is potentially due to endothelial damage/dysfunction (marked by circulating endothelial cells [CECs]), platelet activation (soluble P-selectin [sPsel], platelet microparticles [PMPs], and soluble CD40 [sCD40]), and oxidized low-density lipoprotein (oxLDL) cholesterol. We measured these variables in 24 patients with MVD as well as in 21 with MVD + AF and compared them with 20 healthy controls (HCs). The CECs and PMPs were measured by flow cytometry; sPsel, oxLDL, and CD40 by enzyme-linked immunosorbent assay. Compared with HCs,...
Source: Angiology - July 24, 2015 Category: Cardiology Authors: Idriss, N. K., Blann, A. D., Sayed, D. M., Gaber, M. A., Hassen, H. A., Kishk, Y. T. Tags: Valve Disease Source Type: research
Contrast Volume-to-Creatinine Clearance Ratio Predicts the Risk of Contrast-Induced Nephropathy After Percutaneous Coronary Intervention in Patients With Reduced Ejection Fraction
We determined a relatively safe contrast media volume-to-creatinine clearance (V/CrCl) cutoff value to avoid contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI) in patients (n = 111) with reduced ejection fraction (<40%). Improved prediction of CIN in these patients would be useful. Multivariate regression models were used to evaluate whether V/CrCl is an independent risk factor for CIN. Nine (8.1%) patients developed CIN. The V/CrCl was significantly (P = .023) higher in patients with CIN than in those without. The incidence of CIN in patients with the highest tertile of V/CrCl was signifi...
Source: Angiology - July 24, 2015 Category: Cardiology Authors: Liu, Y., Chen, S.-Q., Duan, C.-Y., Tan, N., Chen, J.-Y., Zhou, Y.-L., Chen, P.-Y., Huang, S.-J., Liu, X.-Q. Tags: Contrast-induced Nephropathy Source Type: research
Epicardial Fat Tissue Predicts Increased Long-Term Major Adverse Cardiac Event in Patients With Moderate Cardiovascular Risk
We investigated the relationship between epicardial fat volume (EFV) measured by multislice computed tomography (MDCT) and long-term major adverse cardiac events (MACEs). Consecutive patients (n = 564) were enrolled in this retrospective study. Patients were divided into tertiles according to EFV. Patients were followed up for an average of 18 months. Patients in each tertile were similar in terms of gender and risk factors. Patients with greater EFV in the third group were more likely to be overweight (P = .001) and older (P = .001). High-density lipoprotein cholesterol levels were relatively lower in the third tertile (4...
Source: Angiology - July 24, 2015 Category: Cardiology Authors: Ulucan, S., Kaya, Z., Efe, D., Keser, A., Katlandur, H., Aygun, F., Ulgen, M. S., Avci, A., Calapkorur, B., Kaya, M. G. Tags: Coronary Artery Disease Source Type: research
Vitamin D and Dysfunctional Adipose Tissue in Obesity
In conclusion, a positive trend was established between vitamin D and the protective adipocytokine adiponectin. The clinical relevance of this relationship needs to be investigated in larger studies. (Source: Angiology)
Source: Angiology - July 24, 2015 Category: Cardiology Authors: Stokic, E., Kupusinac, A., Tomic-Naglic, D., Smiljenic, D., Kovacev-Zavisic, B., Srdic-Galic, B., Soskic, S., Isenovic, E. R. Tags: Obesity Source Type: research
Review of the Use of Ionizing Radiation in Endovascular Aneurysm Repair
Endovascular repair for aortic aneurysm (EVAR) is rapidly increasing in popularity. The nature of this intervention requires significant exposure to ionizing radiation both during the procedure and for postoperative surveillance, generally in the form of computed tomography. Here the authors review the literature for radiation exposure during EVAR, both for the patient and the physician. (Source: Angiology)
Source: Angiology - July 24, 2015 Category: Cardiology Authors: Dindyal, S., Rahman, S., Kyriakides, C. Tags: Review Source Type: research
