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Issue information
(Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - February 24, 2016 Category: Nanotechnology Tags: Issue Information Source Type: research

Inside Cover Image, Volume 8, Issue 2
The cover image, by Brittany Baniket al., is based on the Advanced Review Polymeric Nanoparticles: The Future of Nanomedicine, DOI: 10.1002/wnan.1364. The cover image, by Brittany Baniket al., is based on the Advanced Review Polymeric Nanoparticles: The Future of Nanomedicine, DOI: 10.1002/wnan.1364. (Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - February 24, 2016 Category: Nanotechnology Authors: Brittany L. Banik, Pouria Fattahi, Justin L. Brown Tags: Cover Image Source Type: research

Cover Image, Volume 8, Issue 2
The cover image, by Seungpyo Hong et al., is based on the Advanced Review Recent Advances in Nanotechnology‐based Detection and Separation of Circulating Tumor Cells, DOI: 10.1002/wnan.1360. The cover image, by Seungpyo Hong et al., is based on the Advanced Review Recent Advances in Nanotechnology‐based Detection and Separation of Circulating Tumor Cells, DOI: 10.1002/wnan.1360. (Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - February 24, 2016 Category: Nanotechnology Authors: Ja Hye Myung, Kevin A. Tam, Sin‐jung Park, Ashley Cha, Seungpyo Hong Tags: Cover Image Source Type: research

Development and regulation of exosome ‐based therapy products
Recently, various innovative therapies involving the ex vivo manipulation and subsequent reintroduction of exosome‐based therapeutics into humans have been developed and validated, although no exosome‐based therapeutics have yet to be brought into the clinic. Exosomes are nanosized vesicles secreted by many cells that utilize them for cell‐to‐cell communications to facilitate transport of proteins and genetic material. Comprised of cellular membranes with multiple adhesive proteins on their surface, exosomes offer distinct advantages that exceptionally position them as highly effective drug carriers. Additionally, ...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - February 16, 2016 Category: Nanotechnology Authors: Elena V. Batrakova, Myung Soo Kim Tags: Advanced Review Source Type: research

Nanoparticle formulations of cisplatin for cancer therapy
The genotoxic agent cisplatin, used alone or in combination with radiation and/or other chemotherapeutic agents, is an important first‐line chemotherapy for a broad range of cancers. The clinical utility of cisplatin is limited both by intrinsic and acquired resistance and dose‐limiting normal tissue toxicity. That cisplatin shows little selectivity for tumor versus normal tissue may be a critical factor limiting its value. To overcome the low therapeutic ratio of the free drug, macromolecular, liposomal, and nanoparticle drug delivery systems have been explored toward leveraging the enhanced permeability and retention...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - February 5, 2016 Category: Nanotechnology Authors: Xiaopin Duan, Chunbai He, Stephen J. Kron, Wenbin Lin Tags: Focus Article Source Type: research

Label‐free detection and manipulation of single biological nanoparticles
In the past several years, there have been significant advances in the field of nanoparticle detection for various biological applications. Of considerable interest are synthetic nanoparticles being designed as potential drug delivery systems as well as naturally occurring or biological nanoparticles, including viruses and extracellular vesicles. Many infectious diseases and several human cancers are attributed to individual virions. Because these particles likely display different degrees of heterogeneity under normal physiological conditions, characterization of these natural nanoparticles with single‐particle sensitiv...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - February 5, 2016 Category: Nanotechnology Authors: Michael C. DeSantis, Wei Cheng Tags: Advanced Review Source Type: research

Coaxial electrospun fibers: applications in drug delivery and tissue engineering
Coelectrospinning and emulsion electrospinning are two main methods for preparing core–sheath electrospun nanofibers in a cost‐effective and efficient manner. Here, physical phenomena and the effects of solution and processing parameters on the coaxial fibers are introduced. Coaxial fibers with specific drugs encapsulated in the core can exhibit a sustained and controlled release. Their exhibited high surface area and three‐dimensional nanofibrous network allows the electrospun fibers to resemble native extracellular matrices. These features of the nanofibers show that they have great potential in drug delivery and t...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - February 5, 2016 Category: Nanotechnology Authors: Yang Lu, Jiangnan Huang, Guoqiang Yu, Romel Cardenas, Suying Wei, Evan K. Wujcik, Zhanhu Guo Tags: Overview Source Type: research

Challenges in preclinical to clinical translation for anticancer carrier‐mediated agents
Major advances in carrier‐mediated agents (CMAs), which include nanoparticles and conjugates, have revolutionized drug delivery capabilities over the past decade. While providing numerous advantages over their small‐molecule counterparts, there is substantial variability in how individual CMA formulations and patient characteristics affect the pharmacology, pharmacokinetics (PK), and pharmacodynamics (PD) (efficacy and toxicity) of these agents. Development or selection of animal models is used to predict the effects within a particular human disease. A breadth of studies have begun to emphasize the importance of precl...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - February 5, 2016 Category: Nanotechnology Authors: Andrew T. Lucas, Andrew J. Madden, William C. Zamboni Tags: Opinion Source Type: research

Label ‐free detection and manipulation of single biological nanoparticles
In the past several years, there have been significant advances in the field of nanoparticle detection for various biological applications. Of considerable interest are synthetic nanoparticles being designed as potential drug delivery systems as well as naturally occurring or biological nanoparticles, including viruses and extracellular vesicles. Many infectious diseases and several human cancers are attributed to individual virions. Because these particles likely display different degrees of heterogeneity under normal physiological conditions, characterization of these natural nanoparticles with single‐particle sensitiv...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - February 4, 2016 Category: Nanotechnology Authors: Michael C. DeSantis, Wei Cheng Tags: Advanced Review Source Type: research

Challenges in preclinical to clinical translation for anticancer carrier ‐mediated agents
Major advances in carrier‐mediated agents (CMAs), which include nanoparticles and conjugates, have revolutionized drug delivery capabilities over the past decade. While providing numerous advantages over their small‐molecule counterparts, there is substantial variability in how individual CMA formulations and patient characteristics affect the pharmacology, pharmacokinetics (PK), and pharmacodynamics (PD) (efficacy and toxicity) of these agents. Development or selection of animal models is used to predict the effects within a particular human disease. A breadth of studies have begun to emphasize the importance of precl...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - February 4, 2016 Category: Nanotechnology Authors: Andrew T. Lucas, Andrew J. Madden, William C. Zamboni Tags: Opinion Source Type: research

Cyclodextrin ‐based nanosponges: a versatile platform for cancer nanotherapeutics development
Nanosponges (NSs) are a new age branched cyclodextrin (CD) polymeric systems exhibiting tremendous potential in pharmaceutical, agro science, and biomedical applications. Over the past decade, different varieties of NS based on the type of CD and the crosslinker have been developed tailored for specific applications. NS technology has been instrumental in achieving solubilization, stabilization, sustained release, enhancement of activity, permeability enhancement, protein delivery, ocular delivery, stimuli sensitive drug release, enhancement of bioavailability, etc. There is a major explosion of research in the area of NS�...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - January 21, 2016 Category: Nanotechnology Authors: Shankar Swaminathan, Roberta Cavalli, Francesco Trotta Tags: Advanced Review Source Type: research

Virus ‐based nanoparticles as platform technologies for modern vaccines
Nanoscale engineering is revolutionizing the development of vaccines and immunotherapies. Viruses have played a key role in this field because they can function as prefabricated nanoscaffolds with unique properties that are easy to modify. Viruses are immunogenic via multiple pathways, and antigens displayed naturally or by engineering on the surface can be used to create vaccines against the cognate virus, other pathogens, specific molecules or cellular targets such as tumors. This review focuses on the development of virus‐based nanoparticle systems as vaccines indicated for the prevention or treatment of infectious di...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - January 18, 2016 Category: Nanotechnology Authors: Karin L. Lee, Richard M. Twyman, Steven Fiering, Nicole F. Steinmetz Tags: Advanced Review Source Type: research

pH ‐Sensitive stimulus‐responsive nanocarriers for targeted delivery of therapeutic agents
In recent years miscellaneous smart micro/nanosystems that respond to various exogenous/endogenous stimuli including temperature, magnetic/electric field, mechanical force, ultrasound/light irradiation, redox potentials, and biomolecule concentration have been developed for targeted delivery and release of encapsulated therapeutic agents such as drugs, genes, proteins, and metal ions specifically at their required site of action. Owing to physiological differences between malignant and normal cells, or between tumors and normal tissues, pH‐sensitive nanosystems represent promising smart delivery vehicles for transport an...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - January 13, 2016 Category: Nanotechnology Authors: Mahdi Karimi, Masoud Eslami, Parham Sahandi ‐Zangabad, Fereshteh Mirab, Negar Farajisafiloo, Zahra Shafaei, Deepanjan Ghosh, Mahnaz Bozorgomid, Fariba Dashkhaneh, Michael R. Hamblin Tags: Advanced Review Source Type: research

Development and regulation of exosome‐based therapy products
Recently, various innovative therapies involving the ex vivo manipulation and subsequent reintroduction of exosome‐based therapeutics into humans have been developed and validated, although no exosome‐based therapeutics have yet to be brought into the clinic. Exosomes are nanosized vesicles secreted by many cells that utilize them for cell‐to‐cell communications to facilitate transport of proteins and genetic material. Comprised of cellular membranes with multiple adhesive proteins on their surface, exosomes offer distinct advantages that exceptionally position them as highly effective drug carriers. Additionally, ...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - January 1, 2016 Category: Nanotechnology Authors: Elena V. Batrakova, Myung Soo Kim Tags: Advanced Review Source Type: research

Peptide nanostructures in biomedical technology
Nanostructures of peptides have been investigated for biomedical applications due to their unique mechanical and electrical properties in addition to their excellent biocompatibility. Peptides may form fibrils, spheres and tubes in nanoscale depending on the formation conditions. These peptide nanostructures can be used in electrical, medical, dental, and environmental applications. Applications of these nanostructures include, but are not limited to, electronic devices, biosensing, medical imaging and diagnosis, drug delivery, tissue engineering and stem cell research. This review offers a discussion of basic synthesis me...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - January 1, 2016 Category: Nanotechnology Authors: Hamid Feyzizarnagh, Do‐Young Yoon, Mark Goltz, Dong‐Shik Kim Tags: Advanced Review Source Type: research