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Methodologies and approaches for the analysis of cell –nanoparticle interactions
How to study nanoparticle–cell interactions is the key question that puzzles researchers in the fields of nanomedicine as well as in nanotoxicology. In nanotoxicology, the amount of nanoparticles internalized by the cells or bound to the external surfaces of cells determines the toxic profile of those particles. In medical applications, cellular uptake and binding of medically effective nanoparticles decides their efficacy. Despite the importance of understanding the extent and mode of nanoparticle–cell interactions, these processes are underinvestigated, mainly due to the lack of suitable user‐friendly methodologies...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - July 1, 2017 Category: Nanotechnology Authors: Angela Ivask, Andrew J. Mitchell, Anzhela Malysheva, Nicolas H. Voelcker, Enzo Lombi Tags: Advanced Review Source Type: research

Plant viral and bacteriophage delivery of nucleic acid therapeutics
Nucleic acid therapeutics have emerged as a powerful method for treatment of many diseases. However, the challenge lies in safe and efficient delivery of nucleic acids to their target site, as they need to cross various extracellular and intracellular barriers. Mammalian viruses have initially been favored for delivery of nucleic acid therapeutics, but safety concerns regarding their immunogenicity and potential of integration have fueled the search for alternative delivery strategies. For example, chemistry and bioengineering have led to advances in the use of nonviral vectors composed of lipids and other polymers; nevert...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - July 1, 2017 Category: Nanotechnology Authors: Patricia Lam, Nicole F. Steinmetz Tags: Advanced Review Source Type: research

Genetically encoded iron ‐associated proteins as MRI reporters for molecular and cellular imaging
All cell imaging applications rely on some form of specific cell labeling to achieve visualization of cells contributing to disease or cell therapy. The purpose of this review article is to summarize the published data on genetically encoded iron‐based imaging reporters. The article overviews regulation of iron homeostasis as well as genetically encoded iron‐associated molecular probes and their applications for noninvasive magnetic resonance imaging (MRI) of transplanted cells. Longitudinal repetitive MRI of therapeutic cells is extremely important for providing key functional endpoints and insight into mechanisms of ...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - July 1, 2017 Category: Nanotechnology Authors: Anna V. Naumova, Greetje Vande Velde Tags: Advanced Review Source Type: research

Issue Information
(Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - June 16, 2017 Category: Nanotechnology Tags: Issue Information Source Type: research

Inside Cover Image, Volume 9, Issue 4
The inside cover image, by Tatjana Opacic et al., is based on the Advanced Review Status and trends in the development of clinical diagnostic agents, DOI: 10.1002/wnan.1441. The inside cover image, by Tatjana Opacic et al., is based on the Advanced Review Status and trends in the development of clinical diagnostic agents, DOI: 10.1002/wnan.1441. (Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - June 16, 2017 Category: Nanotechnology Authors: Tatjana Opacic, Vera Paefgen, Twan Lammers, Fabian Kiessling Tags: Cover Image Source Type: research

Cover Image, Volume 9, Issue 4
The front cover image, by Yi Cui et al., is based on the Advanced Review Beyond quantification: in situ analysis of transcriptome and pre‐mRNA alternative splicing at the nanoscale, DOI: 10.1002/wnan.1443. The front cover image, by Yi Cui et al., is based on the Advanced Review Beyond quantification: in situ analysis of transcriptome and pre‐mRNA alternative splicing at the nanoscale, DOI: 10.1002/wnan.1443. (Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - June 16, 2017 Category: Nanotechnology Authors: Yi Cui, Jing Liu, Joseph Irudayaraj Tags: Cover Image Source Type: research

Cell tracking using gold nanoparticles and computed tomography imaging
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology,Volume 10, Issue 2, March/April 2018. (Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - May 24, 2017 Category: Nanotechnology Source Type: research

Oral nucleic acid therapy using multicompartmental delivery systems
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology,Volume 10, Issue 2, March/April 2018. (Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - May 24, 2017 Category: Nanotechnology Source Type: research

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Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology,Volume 10, Issue 2, March/April 2018. (Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - May 24, 2017 Category: Nanotechnology Source Type: research

Oral nucleic acid therapy using multicompartmental delivery systems
Nucleic acid‐based therapeutics has the potential for treating numerous diseases by correcting abnormal expression of specific genes. Lack of safe and efficacious delivery strategies poses a major obstacle limiting clinical advancement of nucleic acid therapeutics. Oral route of drug administration has greater delivery challenges, because the administered genes or oligonucleotides have to bypass degrading environment of the gastrointestinal (GI) tract in addition to overcoming other cellular barriers preventing nucleic acid delivery. For efficient oral nucleic acid delivery, vector should be such that it can protect enca...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - May 24, 2017 Category: Nanotechnology Authors: Husain Attarwala, Murui Han, Jonghan Kim, Mansoor Amiji Tags: Advanced Review Source Type: research

Cell tracking using gold nanoparticles and computed tomography imaging
Cell‐based therapies utilize transplantation of living cells with therapeutic traits to alleviate numerous diseases and disorders. The use of such biological agents is an attractive alternative for diseases that existing medicine cannot effectively treat. Although very promising, translating cell therapy to the clinic has proven to be challenging, due to inconsistent results in preclinical and clinical studies. To examine the underlying cause for these inconsistencies, it is crucial to noninvasively monitor the accuracy of cell injection, and cell survival and migration patterns. The combination of classical imaging tech...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - May 24, 2017 Category: Nanotechnology Authors: Rinat Meir, Rachela Popovtzer Tags: Advanced Review Source Type: research

Effects of food ‐borne nanomaterials on gastrointestinal tissues and microbiota
Ingestion of engineered nanomaterials is inevitable due to their addition to food and prevalence in food packaging and domestic products such as toothpaste and sun cream. In the absence of robust dosimetry and particokinetic data, it is currently challenging to accurately assess the potential toxicity of food‐borne nanomaterials. Herein, we review current understanding of gastrointestinal uptake mechanisms, consider some data on the potential for toxicity of the most commonly encountered classes of food‐borne nanomaterials (including TiO2 , SiO2 , ZnO, and Ag nanoparticles), and discuss the potential impact of the lum...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - May 1, 2017 Category: Nanotechnology Authors: Hans Bouwmeester, Meike van der Zande, Mark A. Jepson Tags: Advanced Review Source Type: research

Nanotherapeutic systems for local treatment of brain tumors
Malignant brain tumor, including the most common type glioblastoma, are histologically heterogeneous and invasive tumors known as the most devastating neoplasms with high morbidity and mortality. Despite multimodal treatment including surgery, radiotherapy, chemotherapy, and immunotherapy, the disease inevitably recurs and is fatal. This lack of curative options has motivated researchers to explore new treatment strategies and to develop new drug delivery systems (DDSs); however, the unique anatomical, physiological, and pathological features of brain tumors greatly limit the effectiveness of conventional chemotherapy. In ...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - May 1, 2017 Category: Nanotechnology Authors: Rami Walid Chakroun, Pengcheng Zhang, Ran Lin, Paula Schiapparelli, Alfredo Quinones ‐Hinojosa, Honggang Cui Tags: Advanced Review Source Type: research

Functional magnetic hybrid nanomaterials for biomedical diagnosis and treatment
Magnetic nanomaterials integrating supplemental functional materials are called magnetic hybrid nanomaterials (MHNs). Such MHNs have drawn increasing attention due to their biocompatibility and the potential applications either as alternative contrast enhancing agents or effective heat nanomediators in hyperthermia therapy. The joint function comes from the hybrid nanostructures. Hybrid nanostructures of different modification can be easily achieved owing to the large surface‐area‐to‐volume ratio and sophisticated surface characteristic. In this focus article, we mainly discussed the design and synthesis of MHNs and ...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - May 1, 2017 Category: Nanotechnology Authors: Xin Tian, Lechuan Zhang, Mo Yang, Lei Bai, Yiheng Dai, Zhiqiang Yu, Yue Pan Tags: Focus Article Source Type: research