Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Advances in the development of aptamer drug conjugates for targeted drug delivery
A key goal of modern medicine is target‐specific therapeutic intervention. However, most drugs lack selectivity, resulting in ‘off‐target’ side effects. To address the requirements of ‘targeted therapy,’ aptamers, which are artificial oligonucleotides, have been used as novel targeting ligands to construct aptamer drug conjugates (ApDC) that can specifically bind to a broad spectrum of targets, including diseased cells. Accordingly, the application of aptamers in targeted drug delivery has attracted broad interest due to their impressive selectivity and affinity, low immunogenicity, easy synthesis with high rep...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - October 30, 2016 Category: Nanotechnology Authors: Ke Chen, Bo Liu , Bo Yu , Wen Zhong , Yi Lu , Jiani Zhang , Jie Liao , Jun Liu , Ying Pu , Liping Qiu , Liqin Zhang , Huixia Liu , Weihong Tan Tags: Focus Article Source Type: research

Functional carbon nanodots for multiscale imaging and therapy
As an emerging class of carbon nanomaterials, carbon dots (CDs) have garnered many researchers’ interests in the past decade due to their excellent biocompatibility, replete surface functional groups, water dispersibility, and unique photoluminescence. These extraordinary properties have opened new avenues for their advanced application in cell labeling, bioimaging, drug delivery, sensors, and energy‐related devices. In this paper, we critically review recent advances in the synthetic strategies and the application of CDs for biological purposes, specifically, imaging and therapy. Finally, a perspective has been given ...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - October 28, 2016 Category: Nanotechnology Authors: Fatemeh Ostadhossein, Dipanjan Pan Tags: Advanced Review Source Type: research

Graphene oxide as a scaffold for bone regeneration
Graphene oxide (GO), the oxidized form of graphene, holds great potential as a component of biomedical devices, deriving utility from its ability to support a broad range of chemical functionalities and its exceptional mechanical, electronic, and thermal properties. GO composites can be tuned chemically to be biomimetic, and mechanically to be stiff yet strong. These unique properties make GO‐based materials promising candidates as a scaffold for bone regeneration. However, questions still exist as to the compatibility and long‐term toxicity of nanocarbon materials. Unlike other nanocarbons, GO is meta‐stable, water ...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - October 26, 2016 Category: Nanotechnology Authors: Brian D. Holt, Zoe M. Wright, Anne M. Arnold, Stefanie A. Sydlik Tags: Advanced Review Source Type: research

Issue information
(Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - October 13, 2016 Category: Nanotechnology Tags: Issue Information Source Type: research

Cover Image, Volume 8, Issue 6
The cover image, by Gang Zheng et al., is based on the Advanced Review Multimodal micro, nano, and size conversion ultrasound agents for imaging and therapy, DOI: 10.1002/wnan.1398. The cover image, by Gang Zheng et al., is based on the Advanced Review Multimodal micro, nano, and size conversion ultrasound agents for imaging and therapy, DOI: 10.1002/wnan.1398. (Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - October 13, 2016 Category: Nanotechnology Authors: Elizabeth Huynh, Maneesha A. Rajora, Gang Zheng Tags: Cover Image Source Type: research

α‐Helical coiled‐coil peptide materials for biomedical applications
Self‐assembling coiled coils, which occur commonly in native proteins, have received significant interest for the design of new biomaterials‐based medical therapies. Considerable effort over recent years has led to a detailed understanding of the self‐assembly process of coiled coils, and a diverse collection of strategies have been developed for designing functional materials using this motif. The ability to engineer the interface between coiled coils allows one to achieve variously connected components, leading to precisely defined structures such as nanofibers, nanotubes, nanoparticles, networks, gels, and combina...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - September 5, 2016 Category: Nanotechnology Authors: Yaoying Wu, Joel H. Collier Tags: Overview Source Type: research

Recent advances of using polyhydroxyalkanoate ‐based nanovehicles as therapeutic delivery carriers
Polyhydroxyalkanoates (PHAs) are a class of diverse biodegradable polyesters that can be produced either by natural bioconversion process or by chemical synthesis via the ring‐opening polymerization of β‐lactones. Because of the excellent biodegradability and biocompatibility, the development of PHA‐based nanovehicles as therapeutic delivery carriers, including nanoparticles, micelles, liposomes, and vesicles, has received considerable attention in recent years, and these sophisticated materials have demonstrated significant impact on the drug bioavailability, better encapsulation, and less toxic properties of biode...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - August 31, 2016 Category: Nanotechnology Authors: Zibiao Li, Xian Jun Loh Tags: Advanced Review Source Type: research

Challenges to develop novel anti ‐inflammatory and analgesic drugs
Chronic inflammatory diseases and persistent pain of different origin represent common medical, social, and economic burden, and their pharmacotherapy is still an unresolved issue. Therefore, there is a great and urgent need to develop anti‐inflammatory and analgesic agents with novel mechanisms of action, but it is a very challenging task. The main problem is the relatively large translational gap between the preclinical experimental data and the clinical results due to characteristics of the models, difficulties with the investigational techniques particularly for pain, as well as species differences in the mechanisms....
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - August 31, 2016 Category: Nanotechnology Authors: B álint Botz, Kata Bölcskei, Zsuzsanna Helyes Tags: Advanced Review Source Type: research

Systems ‐level thinking for nanoparticle‐mediated therapeutic delivery to neurological diseases
Neurological diseases account for 13% of the global burden of disease. As a result, treating these diseases costs $750 billion a year. Nanotechnology, which consists of small (~1–100 nm) but highly tailorable platforms, can provide significant opportunities for improving therapeutic delivery to the brain. Nanoparticles can increase drug solubility, overcome the blood–brain and brain penetration barriers, and provide timed release of a drug at a site of interest. Many researchers have successfully used nanotechnology to overcome individual barriers to therapeutic delivery to the brain, yet no platform has translated i...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - August 26, 2016 Category: Nanotechnology Authors: Chad Curtis, Mengying Zhang, Rick Liao, Thomas Wood, Elizabeth Nance Tags: Advanced Review Source Type: research

Microtubule ‐based force generation
Microtubules are vital to many important cell processes, such as cell division, transport of cellular cargo, organelle positioning, and cell migration. Owing to their diverse functions, understanding microtubule function is an important part of cell biological research that can help in combating various diseases. For example, microtubules are an important target of chemotherapeutic drugs such as paclitaxel because of their pivotal role in cell division. Many functions of microtubules relate to the generation of mechanical forces. These forces are generally either a direct result of microtubule polymerization/depolymerizati...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - August 24, 2016 Category: Nanotechnology Authors: Ian A. Kent, Tanmay P. Lele Tags: Focus Article Source Type: research

Issue information
(Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - August 11, 2016 Category: Nanotechnology Tags: Issue Information Source Type: research

Inside Cover Image, Volume 8, Issue 5
The inside cover image, by Evan K. Wujcik et al., is based on the Overview Coaxial electrospun fibers: applications in drug delivery and tissue engineering, DOI: 10.1002/wnan.1391. The inside cover image, by Evan K. Wujcik et al., is based on the Overview Coaxial electrospun fibers: applications in drug delivery and tissue engineering, DOI: 10.1002/wnan.1391. (Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - August 11, 2016 Category: Nanotechnology Authors: Yang Lu, Jiangnan Huang, Guoqiang Yu, Romel Cardenas, Suying Wei, Evan K. Wujcik, Zhanhu Guo Tags: Cover Image Source Type: research

Cover Image, Volume 8, Issue 5
The cover image, by Michael C. DeSantis and Wei Cheng, is based on the Advanced Review Label‐free detection and manipulation of single biological nanoparticles, DOI: 10.1002/wnan.1392. The cover image, by Michael C. DeSantis and Wei Cheng, is based on the Advanced Review Label‐free detection and manipulation of single biological nanoparticles, DOI: 10.1002/wnan.1392. (Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - August 11, 2016 Category: Nanotechnology Authors: Michael C. DeSantis, Wei Cheng Tags: Cover Image Source Type: research

Amylose engineering: phosphorylase ‐catalyzed polymerization of functional saccharide primers for glycobiomaterials
Interest in amylose and its hybrids has grown over many decades, and a great deal of work has been devoted to developing methods for designing functional amylose hybrids. In this context, phosphorylase‐catalyzed polymerization shows considerable promise as a tool for preparing diverse amylose hybrids. Recently, advances have been made in the chemoenzymatic synthesis and characterization of amylose‐block‐polymers, amylose‐graft‐polymers, amylose‐modified surfaces, hetero‐oligosaccharides, and cellodextrin hybrids. Many of these saccharides provide clear opportunities for advances in biomaterials because of the...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - June 30, 2016 Category: Nanotechnology Authors: Tomoki Nishimura, Kazunari Akiyoshi Tags: Advanced Review Source Type: research

Delivery of therapeutics with nanoparticles: what's new in cancer immunotherapy?
The application of nanotechnology to the treatment of cancer or other diseases has been boosted during the last decades due to the possibility to precise deliver drugs where needed, enabling a decrease in the drug's side effects. Nanocarriers are particularly valuable for potentiating the simultaneous co‐delivery of multiple drugs in the same particle for the treatment of heavily burdening diseases like cancer. Immunotherapy represents a new concept in the treatment of cancer and has shown outstanding results in patients treated with check‐point inhibitors. Thereby, researchers are applying nanotechnology to cancer imm...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - June 30, 2016 Category: Nanotechnology Authors: Flavia Fontana, Dongfei Liu, Jouni Hirvonen, H élder A. Santos Tags: Overview Source Type: research