Cardiac catheterization: consequences for the endothelium and potential for nanomedicine
(Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - April 20, 2016 Category: Nanotechnology Tags: Corrigendum Source Type: research

Issue information
(Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - April 20, 2016 Category: Nanotechnology Tags: Issue Information Source Type: research

Cover Image, Volume 8, Issue 3
The cover image, by Estefania Gonzalez Solveyra and Igal Szleifer, is based on the Overview What is the role of curvature on the properties of nanomaterials for biomedical applications?, DOI: 10.1002/wnan.1365. The cover image, by Estefania Gonzalez Solveyra and Igal Szleifer, is based on the Overview What is the role of curvature on the properties of nanomaterials for biomedical applications?, DOI: 10.1002/wnan.1365. (Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - April 20, 2016 Category: Nanotechnology Authors: Estefania Gonzalez Solveyra, Igal Szleifer Tags: Cover Image Source Type: research

Multifunctional platinum ‐based nanoparticles for biomedical applications
Platinum‐based anticancer drugs play a central role in current cancer therapy. However, their applicability and efficacy are limited by drug resistance and adverse effects. Nanocarrier‐based platinum drug delivery systems are promising alternatives to circumvent the disadvantages of bare platinum drugs. The various properties of nanoparticle chemistry allow for the trend toward multiple functionality. Nanoparticles preferentially accumulate at the tumor site through passive targeting, and the attachment of tumor targeting moieties further enhances their tumor‐specific localization as well as tumor cell uptake. The in...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - April 19, 2016 Category: Nanotechnology Authors: Qinqin Cheng, Yangzhong Liu Tags: Advanced Review Source Type: research

Photoactivated drug delivery and bioimaging
Among the various types of diseases, cancer remains one of the most leading causes of mortality that people are always suffering from and fighting with. So far, the effective cancer treatment demands accurate medical diagnosis, precise surgery, expensive medicine administration, which leads to a significant burden on patients, their families, and the whole national healthcare system around the world. In order to increase the therapeutic efficiency and minimize side effects in cancer treatment, various kinds of stimuli‐responsive drug delivery systems and bioimaging platforms have been extensively developed within the pas...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - April 19, 2016 Category: Nanotechnology Authors: Yanmei Yang, Jing Mu, Bengang Xing Tags: Overview Source Type: research

What is new in nanoparticle ‐based photoacoustic imaging?
Photoacoustic imaging combines the high temporal and spatial resolution of ultrasound with the good contrast and spectral tuning of optical imaging. Contrast agents are used in photoacoustic imaging to further increase the contrast and specificity of imaging or to image a specific molecular process, e.g., cell‐surface proteins or small molecule biomarkers. Nanoparticle‐based contrast agents are important tools in photoacoustic imaging because they offer intense and stable signal and can be targeted to specific molecular processes. In this review, we describe some of the most interesting and recent advances in nanoparti...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - March 31, 2016 Category: Nanotechnology Authors: Jeanne E. Lemaster, Jesse V. Jokerst Tags: Opinion Source Type: research

Particulate delivery systems for vaccination against bioterrorism agents and emerging infectious pathogens
Bioterrorism agents that can be easily transmitted with high mortality rates and cause debilitating diseases pose major threats to national security and public health. The recent Ebola virus outbreak in West Africa and ongoing Zika virus outbreak in Brazil, now spreading throughout Latin America, are case examples of emerging infectious pathogens that have incited widespread fear and economic and social disruption on a global scale. Prophylactic vaccines would provide effective countermeasures against infectious pathogens and biological warfare agents. However, traditional approaches relying on attenuated or inactivated va...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - March 31, 2016 Category: Nanotechnology Authors: Yuchen Fan, James J. Moon Tags: Advanced Review Source Type: research

What is new in nanoparticle‐based photoacoustic imaging?
Photoacoustic imaging combines the high temporal and spatial resolution of ultrasound with the good contrast and spectral tuning of optical imaging. Contrast agents are used in photoacoustic imaging to further increase the contrast and specificity of imaging or to image a specific molecular process, e.g., cell‐surface proteins or small molecule biomarkers. Nanoparticle‐based contrast agents are important tools in photoacoustic imaging because they offer intense and stable signal and can be targeted to specific molecular processes. In this review, we describe some of the most interesting and recent advances in nanoparti...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - March 31, 2016 Category: Nanotechnology Authors: Jeanne E. Lemaster, Jesse V. Jokerst Tags: Opinion Source Type: research

Multimodal micro, nano, and size conversion ultrasound agents for imaging and therapy
Ultrasound (US) is one of the most commonly used clinical imaging techniques. However, the use of US and US‐based intravenous agents extends far beyond imaging. In particular, there has been a surge in the fabrication of multimodality US contrast agents and theranostic US agents for cancer imaging and therapy. The unique interaction of US waves with microscale and nanoscale agents has attracted much attention in the development of contrast agents and drug‐delivery vehicles. The dimensions of the agent not only dictate how it behaves in vivo, but also how it interacts with US for imaging and drug delivery. Furthermore, ...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - March 22, 2016 Category: Nanotechnology Authors: Elizabeth Huynh, Maneesha A. Rajora, Gang Zheng Tags: Advanced Review Source Type: research

Structural colors: from natural to artificial systems
Structural coloration has attracted great interest from scientists and engineers in recent years, owing to fascination with various brilliant examples displayed in nature as well as to promising applications of bio‐inspired functional photonic structures and materials. Much research has been done to reveal and emulate the physical mechanisms that underlie the structural colors found in nature. In this article, we review the fundamental physics of many natural structural colors displayed by living organisms as well as their bio‐inspired artificial counterparts, with emphasis on their connections, tunability strategies, ...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - March 1, 2016 Category: Nanotechnology Authors: Yulan Fu, Cary A. Tippets, Eugenii U. Donev, Rene Lopez Tags: Advanced Review Source Type: research

Multifunctional platinum‐based nanoparticles for biomedical applications
Platinum‐based anticancer drugs play a central role in current cancer therapy. However, their applicability and efficacy are limited by drug resistance and adverse effects. Nanocarrier‐based platinum drug delivery systems are promising alternatives to circumvent the disadvantages of bare platinum drugs. The various properties of nanoparticle chemistry allow for the trend toward multiple functionality. Nanoparticles preferentially accumulate at the tumor site through passive targeting, and the attachment of tumor targeting moieties further enhances their tumor‐specific localization as well as tumor cell uptake. The in...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - February 29, 2016 Category: Nanotechnology Authors: Qinqin Cheng, Yangzhong Liu Tags: Advanced Review Source Type: research

Functional nanoparticles for magnetic resonance imaging
Nanoparticle‐based magnetic resonance imaging (MRI) contrast agents have received much attention over the past decade. By virtue of a high payload of magnetic moieties, enhanced accumulation at disease sites, and a large surface area for additional modification with targeting ligands, nanoparticle‐based contrast agents offer promising new platforms to further enhance the high resolution and sensitivity of MRI for various biomedical applications. T 2* superparamagnetic iron oxide nanoparticles (SPIONs) first demonstrated superior improvement on MRI sensitivity. The prevailing SPION attracted growing interest in the deve...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - February 29, 2016 Category: Nanotechnology Authors: Xinpei Mao, Jiadi Xu, Honggang Cui Tags: Advanced Review Source Type: research

Modifying the tumor microenvironment using nanoparticle therapeutics
Treatment of cancer has come a long way from the initial ‘radical surgeries’ to the multimodality treatments. For the major part of the last century, cancer was considered as a monocellular disorder, and treatment strategies were designed according to that hypothesis. However, the mortality rate from cancer continued to be high and a comprehensive treatment remained elusive. Recent progress in research has demonstrated that tumors are a complex network of neoplastic and non‐neoplastic cells. The non‐neoplastic cells, which are collectively called stroma, assist in tumor survival and progression. It has been shown t...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - February 29, 2016 Category: Nanotechnology Authors: Aniruddha Roy, Shyh‐Dar Li Tags: Advanced Review Source Type: research

Polymeric nanoparticles in development for treatment of pulmonary infectious diseases
Serious lung infections, such as pneumonia, tuberculosis, and chronic obstructive cystic fibrosis‐related bacterial diseases, are increasingly difficult to treat and can be life‐threatening. Over the last decades, an array of therapeutics and/or diagnostics have been exploited for management of pulmonary infections, but the advent of drug‐resistant bacteria and the adverse conditions experienced upon reaching the lung environment urge the development of more effective delivery vehicles. Nanotechnology is revolutionizing the approach to circumventing these barriers, enabling better management of pulmonary infectious d...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - February 29, 2016 Category: Nanotechnology Authors: Young H. Lim, Kristin M. Tiemann, David A. Hunstad, Mahmoud Elsabahy, Karen L. Wooley Tags: Advanced Review Source Type: research

Nanoparticles and radiotracers: advances toward radionanomedicine
In this study, we cover the convergence of radiochemistry for imaging and therapy with advances in nanoparticle (NP) design for biomedical applications. We first explore NP properties relevant for therapy and theranostics and emphasize the need for biocompatibility. We then explore radionuclide‐imaging modalities such as positron emission tomography (PET), single‐photon emission computed tomography (SPECT), and Cerenkov luminescence (CL) with examples utilizing radiolabeled NP for imaging. PET and SPECT have served as diagnostic workhorses in the clinic, while preclinical NP design examples of multimodal imaging with r...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - February 29, 2016 Category: Nanotechnology Authors: Edwin C. Pratt, Travis M. Shaffer, Jan Grimm Tags: Advanced Review Source Type: research