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Nanophotonic trapping: precise manipulation and measurement of biomolecular arrays
Optical trapping is a powerful and widely used laboratory technique in the biological and materials sciences that enables rapid manipulation and measurement at the nanometer scale. However, expanding the analytical throughput of this technique beyond the serial capabilities of established single‐trap microscope‐based optical tweezers remains a current goal in the field. In recent years, advances in nanotechnology have been leveraged to create innovative optical trapping methods that increase the number of available optical traps and permit parallel manipulation and measurement of arrays of optically trapped targets. In...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - April 25, 2017 Category: Nanotechnology Authors: James E. Baker, Ryan P. Badman, Michelle D. Wang Tags: Advanced Review Source Type: research

Nanocarrier mediated retinal drug delivery: overcoming ocular barriers to treat posterior eye diseases
Effective drug delivery to the retina still remains a challenge due to ocular elimination mechanisms and complex barriers that selectively limit the entry of drugs into the eye. To overcome these barriers, frequent intravitreal injections are currently used to achieve high drug concentrations in vitreous and retina. However, these repetitive injections may result in several side effects. Recent advancements in the field of nanoparticle‐based drug delivery could overcome some of these unmet needs and various preclinical studies conducted to date have demonstrated promising results of nanotherapies in the treatment of reti...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - April 20, 2017 Category: Nanotechnology Authors: Rohit Bisht, Abhirup Mandal, Jagdish K. Jaiswal, Ilva D. Rupenthal Tags: Advanced Review Source Type: research

Nanocarrier mediated retinal drug delivery: overcoming ocular barriers to treat posterior eye diseases
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology,Volume 10, Issue 2, March/April 2018. (Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - April 20, 2017 Category: Nanotechnology Source Type: research

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Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology,Volume 10, Issue 2, March/April 2018. (Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - April 20, 2017 Category: Nanotechnology Source Type: research

Issue information
(Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - April 12, 2017 Category: Nanotechnology Tags: Issue Information Source Type: research

Cover Image, Volume 9, Issue 3
The cover image, by Aaron H. Colby et al., is based on the Advanced Review Nanoparticle drug‐delivery systems for peritoneal cancers: a case study of the design, characterization and development of the expansile nanoparticle, DOI: 10.1002/wnan.1451. The cover image, by Aaron H. Colby et al., is based on the Advanced Review Nanoparticle drug‐delivery systems for peritoneal cancers: a case study of the design, characterization and development of the expansile nanoparticle, DOI: 10.1002/wnan.1451. (Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - April 12, 2017 Category: Nanotechnology Authors: Aaron H. Colby, Nicholas H. Oberlies, Cedric J. Pearce, Victoria L.M. Herrera, Yolonda L. Colson, Mark W. Grinstaff Tags: Cover Image Source Type: research

Nanotherapy for Duchenne muscular dystrophy
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology,Volume 10, Issue 2, March/April 2018. (Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - April 11, 2017 Category: Nanotechnology Source Type: research

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Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology,Volume 10, Issue 2, March/April 2018. (Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - April 11, 2017 Category: Nanotechnology Source Type: research

Magnetic resonance relaxation induced by superparamagnetic particles used as contrast agents in magnetic resonance imaging: a theoretical review
Superparamagnetic nanoparticles are used as contrast agents in magnetic resonance imaging and allow, for example, the detection of tumors or the tracking of stem cells in vivo. By producing magnetic inhomogeneities, they influence the nuclear magnetic relaxation times, which results in a darkening, on the image, of the region containing these particles. A great number of studies have been devoted to their magnetic properties, to their synthesis and to their influence on nuclear magnetic relaxation. The theoretical and fundamental understanding of the behavior of these particles is a necessary step in predicting their effic...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - April 11, 2017 Category: Nanotechnology Authors: Quoc Lam Vuong, Pierre Gillis, Alain Roch, Yves Gossuin Tags: Advanced Review Source Type: research

An update on carbon nanotube ‐enabled X‐ray sources for biomedical imaging
A new imaging technology has emerged that uses carbon nanotubes (CNT) as the electron emitter (cathode) for the X‐ray tube. Since the performance of the CNT cathode is controlled by simple voltage manipulation, CNT‐enabled X‐ray sources are ideal for the repetitive imaging steps needed to capture three‐dimensional information. As such, they have allowed the development of a gated micro‐computed tomography (CT) scanner for small animal research as well as stationary tomosynthesis, an experimental technology for large field‐of‐view human imaging. The small animal CT can acquire images at specific points in the ...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - April 11, 2017 Category: Nanotechnology Authors: Connor Puett, Christina Inscoe, Allison Hartman, Jabari Calliste, Dora K. Franceschi, Jianping Lu, Otto Zhou, Yueh Z. Lee Tags: Advanced Review Source Type: research

Targeted nanoparticles for head and neck cancers: overview and perspectives
Head and neck cancer (HNC) is common in several regions and is associated with high morbidity and mortality worldwide. This review summarizes the recent progress in the development of targeted nanoparticle systems for HNC therapy. WIREs Nanomed Nanobiotechnol 2017, 9:e1469. doi: 10.1002/wnan.1469 For further resources related to this article, please visit the WIREs website. Head and neck cancer statistics worldwide. (Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - April 7, 2017 Category: Nanotechnology Authors: Yuying Zhao, Haolin Chen, Xing Chen, Geoffrey Hollett, Zhipeng Gu, Jun Wu, Xiqiang Liu Tags: Overview Source Type: research

Targeted nanoparticle for head and neck cancers: overview and perspectives
Head and neck cancer (HNC) is common in several regions and is associated with high morbidity and mortality worldwide. This review summarizes the recent progress in the development of targeted nanoparticle systems for HNC therapy. For further resources related to this article, please visit the WIREs website. Head and neck cancer statistics worldwide. (Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - April 7, 2017 Category: Nanotechnology Authors: Yuying Zhao, Haolin Chen, Xing Chen, Geoffrey Hollett, Zhipeng Gu, Jun Wu, Xiqiang Liu Tags: Overview Source Type: research

Ultra ‐small superparamagnetic iron oxides for metastatic lymph node detection: back on the block
In the past 15 years, encouraging clinical results for the detection of small lymph node metastases was obtained by the use of Combidex‐enhanced MRI (CEM, also known as magnetic resonance lymphography). Withdrawal of the European Medicines Agency approval application by the manufacturer made it impossible for patients to benefit from this agent; a loss, especially for men with prostate cancer. Current conventional imaging techniques are not as accurate as CEM is, thus a surgical diagnostic exploration (extended lymph node dissection) is still the preferred technique to evaluate the lymph nodes, resulting in peri‐ and...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - April 6, 2017 Category: Nanotechnology Authors: Ansje S. Fortuin, Roger Br üggemann, Janine Linden, Ilia Panfilov, Bas Israël, Tom W.J. Scheenen, Jelle O. Barentsz Tags: Focus Article Source Type: research

Bio ‐inspired nanomedicine strategies for artificial blood components
Blood is a fluid connective tissue where living cells are suspended in noncellular liquid matrix. The cellular components of blood render gas exchange (RBCs), immune surveillance (WBCs) and hemostatic responses (platelets), and the noncellular components (salts, proteins, etc.) provide nutrition to various tissues in the body. Dysfunction and deficiencies in these blood components can lead to significant tissue morbidity and mortality. Consequently, transfusion of whole blood or its components is a clinical mainstay in the management of trauma, surgery, myelosuppression, and congenital blood disorders. However, donor‐der...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - March 14, 2017 Category: Nanotechnology Authors: Anirban Sen Gupta Tags: Advanced Review Source Type: research

Protein corona and nanoparticles: how can we investigate on?
Nanoparticles (NPs) represent one of the most promising tools for drug‐targeting and drug‐delivery. However, a deeper understanding of the complex dynamics that happen after their in vivo administration is required. Particularly, plasma proteins tend to associate to NPs, forming a new surface named the ‘protein corona’ (PC). This surface is the most exposed as the ‘visible side’ of NPs and therefore, can have a strong impact on NP biodistribution, targeting efficacy and also toxicity. The PC consists of two poorly delimited layers, known as ‘hard corona’ (HC) and ‘soft corona’ (SC), that are affected by...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - March 14, 2017 Category: Nanotechnology Authors: Francesca Pederzoli, Giovanni Tosi, Maria Angela Vandelli, Daniela Belletti, Flavio Forni, Barbara Ruozi Tags: Overview Source Type: research