Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Nanotherapy for Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is a lethal X‐linked childhood muscle wasting disease caused by mutations in the dystrophin gene. Nanobiotechnology‐based therapies (such as synthetic nanoparticles and naturally existing viral and nonviral nanoparticles) hold great promise to replace and repair the mutated dystrophin gene and significantly change the disease course. While a majority of DMD nanotherapies are still in early preclinical development, several [such as adeno‐associated virus (AAV)‐mediated systemic micro‐dystrophin gene therapy] are advancing for phase I clinical trials. Recent regulatory approval of ...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - March 1, 2017 Category: Nanotechnology Authors: Michael E. Nance, Chady H. Hakim, N. Nora Yang, Dongsheng Duan Tags: Focus Article Source Type: research

Gold nanoparticles in cardiovascular imaging
In this study, we detail the most promising preclinical scientific progresses based on the use of GNPs for imaging in cardiovascular field and their improvements for a potential clinical application. For further resources related to this article, please visit the WIREs website. Gold nanoparticles and cardiovascular imaging. (Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - March 1, 2017 Category: Nanotechnology Authors: Mariana Varna, Hoa V. Xuan, Emmanuel Fort Tags: Overview Source Type: research

Antibodies from plants for bionanomaterials
Antibodies are produced as part of the vertebrate adaptive immune response and are not naturally made by plants. However, antibody DNA sequences can be introduced into plants, and together with laboratory technologies that allow the design of antibodies recognizing any conceivable molecular structure, plants can be used as ‘green factories’ to produce any antibody at all. The advent of plant‐based transient expression systems in particular allows the rapid, convenient, and safe production of antibodies, ranging from laboratory‐scale expression to industrial‐scale manufacturing. The key features of plant‐based p...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - March 1, 2017 Category: Nanotechnology Authors: Gueven Edgue, Richard M Twyman, Veronique Beiss, Rainer Fischer, Markus Sack Tags: Overview Source Type: research

Multifunctional nanoparticle composites: progress in the use of soft and hard nanoparticles for drug delivery and imaging
With continued advancements in nanoparticle (NP) synthesis and in the interfacing of NPs with biological systems has come the exponential growth in the use of NPs for therapeutic drug delivery and imaging applications. In recent years, the advent of NP multifunctionality—the ability to perform multiple, disparate functions on a single NP platform—has garnered much excitement for the potential realization of highly functional NP‐mediated drug delivery for use in the clinical setting. This Overview will survey the current state of the art (reports published within the last 5 years) of multifunctional NPs for therapeuti...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - February 28, 2017 Category: Nanotechnology Authors: Ajmeeta Sangtani, Okhil K. Nag, Lauren D. Field, Joyce C. Breger, James B. Delehanty Tags: Overview Source Type: research

Promise and peril in nanomedicine: the challenges and needs for integrated systems biology approaches to define health risk
This article will provide a concise opinion on the state‐of‐the‐art, the challenges, and the use of systems biology—another equally revolutionary field of science—to assess the unique health hazards of nanomaterial exposures. For further resources related to this article, please visit the WIREs website. Safe application of nanomaterials in therapeutics requires a deeper understanding of the material properties and behaviors at different levels of biological organization; increasing insight necessitates cross‐disciplinary research collaborations. (Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - February 28, 2017 Category: Nanotechnology Authors: Sabina Halappanavar, Ulla Vogel, Hakan Wallin, Carole L Yauk Tags: Opinion Source Type: research

Pioneering medical advances through nanofluidic implantable technologies
Discussion includes current limitations and future directions for these systems, as commensurate advances in power density and electronic processing are continually redefining the possible. As the research and funding attention coincide with complementary technological breakthroughs, the field is expected to grow into an advanced toolset for preserving human health. a) Render of a next‐generation, nanofluidic implantable system capable of active controlled delivery. (b and c) Illustration of how ion concentration polarization (ICP) is employed for active control. (d) Graph of dendritic fullerene 1 release modulation ove...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - February 28, 2017 Category: Nanotechnology Authors: R. Lyle Hood, Gold Darr Hood, Mauro Ferrari, Alessandro Grattoni Tags: Advanced Review Source Type: research

Nanomedicine approaches to improve cancer immunotherapy
Significant advances have been made in the field of cancer immunotherapy by orchestrating the body's immune system to eradicate cancer cells. However, safety and efficacy concerns stemming from the systemic delivery of immunomodulatory compounds limits cancer immunotherapies expansion and application. In this context, nanotechnology presents a number of advantages, such as targeted delivery to immune cells, enhanced clinical outcomes, and reduced adverse events, which may aid in the delivery of cancer vaccines and immunomodulatory agents. With this in mind, a diverse range of nanomaterials with different physicochemical ch...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - February 28, 2017 Category: Nanotechnology Authors: Hui Qiu, Yuanzeng Min, Zach Rodgers, Longzhen Zhang, Andrew Z. Wang Tags: Advanced Review Source Type: research

ELISA ‐type assays of trace biomarkers using microfluidic methods
Recently, great progress has been achieved for analytical technologies for biological substances. Traditionally, detection methods for analytes mainly rely on large instrumental analyses. These methods require costly equipment, skilled operators and long measurement time despite their generally low sensitivity. In contrast, immunoassays are becoming more and more popular for it is powerful, inexpensive, and convenient nature. Immunoassay has a range of applications, because it employs antibody, a protein produced by plasma cells in the acquired immune system to identify and neutralize diverse pathogens and other exogenous ...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - February 21, 2017 Category: Nanotechnology Authors: Jinhua Dong, Hiroshi Ueda Tags: Overview Source Type: research

Stimuli ‐responsive liposomes for drug delivery
The ultimate goal of drug delivery is to increase the bioavailability and reduce the toxic side effects of the active pharmaceutical ingredient (API) by releasing them at a specific site of action. In the case of antitumor therapy, association of the therapeutic agent with a carrier system can minimize damage to healthy, nontarget tissues, while limit systemic release and promoting long circulation to enhance uptake at the cancerous site due to the enhanced permeation and retention effect (EPR). Stimuli‐responsive systems have become a promising way to deliver and release payloads in a site‐selective manner. Potential ...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - February 15, 2017 Category: Nanotechnology Authors: Y. Lee, D.H. Thompson Tags: Advanced Review Source Type: research

In vitro microfluidic models of tumor microenvironment to screen transport of drugs and nanoparticles
Advances in nanotechnology have enabled numerous types of nanoparticles (NPs) to improve drug delivery to tumors. While many NP systems have been proposed, their clinical translation has been less than anticipated primarily due to failure of current preclinical evaluation techniques to adequately model the complex interactions between the NP and physiological barriers of tumor microenvironment. This review focuses on microfluidic tumor models for characterization of delivery efficacy and toxicity of cancer nanomedicine. Microfluidics offer significant advantages over traditional macroscale cell cultures by enabling recapit...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - February 15, 2017 Category: Nanotechnology Authors: Altug Ozcelikkale, Hye ‐ran Moon, Michael Linnes, Bumsoo Han Tags: Advanced Review Source Type: research

Deconstruction of complex protein signaling switches: a roadmap toward engineering higher ‐order gene regulators
The control of gene expression is an important tool for metabolic engineering, the design of synthetic gene networks, gene‐function analysis, and protein manufacturing. The most successful approaches to date are based on modulating messenger RNA (mRNA) synthesis via their inducible coupling to transcriptional effectors, which requires biosensing functionality. A hallmark of biological sensing is the conversion of an exogenous signal, usually a small molecule or environmental cue such as a protein–ligand interaction, into a useful output or response. One of the most utilized regulatory proteins is the lactose repressor ...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - February 10, 2017 Category: Nanotechnology Authors: James  A. Davey, Corey J. Wilson Tags: Advanced Review Source Type: research

Nanoparticle drug ‐delivery systems for peritoneal cancers: a case study of the design, characterization and development of the expansile nanoparticle
Nanoparticle (NP)‐based drug‐delivery systems are frequently employed to improve the intravenous administration of chemotherapy; however, few reports explore their application as an intraperitoneal therapy. We developed a pH‐responsive expansile nanoparticle (eNP) specifically designed to leverage the intraperitoneal route of administration to treat intraperitoneal malignancies, such as mesothelioma, ovarian, and pancreatic carcinomatoses. This review describes the design, evaluation, and evolution of the eNP technology and, specifically, a Materials‐Based Targeting paradigm that is unique among the many active‐ ...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - February 8, 2017 Category: Nanotechnology Authors: Aaron H. Colby, Nicholas H. Oberlies, Cedric J. Pearce, Victoria L.M. Herrera, Yolonda L. Colson, Mark W. Grinstaff Tags: Advanced Review Source Type: research

Issue information
(Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - February 8, 2017 Category: Nanotechnology Tags: Issue Information Source Type: research

Cover Image, Volume 9, Issue 2
The cover image, by Elizabeth Nance et al., is based on the Advanced Review Systems‐level thinking for nanoparticlemediated therapeutic delivery to neurological diseases, DOI: 10.1002/wnan.1422. The cover image, by Elizabeth Nance et al., is based on the Advanced Review Systems‐level thinking for nanoparticlemediated therapeutic delivery to neurological diseases, DOI: 10.1002/wnan.1422. (Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - February 8, 2017 Category: Nanotechnology Authors: Chad Curtis, Mengying Zhang, Rick Liao, Thomas Wood, Elizabeth Nance Tags: Cover Image Source Type: research

Nanoescapology: progress toward understanding the endosomal escape of polymeric nanoparticles
Using nanoparticles to deliver drugs to cells has the potential to revolutionize the treatment of many diseases, including HIV, cancer, and diabetes. One of the major challenges facing this field is controlling where the drug is trafficked once the nanoparticle is taken up into the cell. In particular, if drugs remain localized in an endosomal or lysosomal compartment, the therapeutic can be rendered completely ineffective. To ensure the design of more effective delivery systems we must first develop a better understanding of how nanoparticles and their cargo are trafficked inside cells. This needs to be combined with an u...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - February 2, 2017 Category: Nanotechnology Authors: Laura I. Selby, Christina M. Cortez ‐Jugo, Georgina K. Such, Angus P.R. Johnston Tags: Advanced Review Source Type: research