Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The effects of nanomaterials on blood coagulation in hemostasis and thrombosis
The blood coagulation balance in the organism is achieved by the interaction of the blood platelets (PLTs) with the plasma coagulation system (PCS) and the vascular endothelial cells. In healthy organism, these systems prevent thrombosis and, in events of vascular damage, enable blood clotting to stop bleeding. The dysregulation of hemostasis may cause serious thrombotic and/or hemorrhagic pathologies. Numerous engineered nanomaterials are being investigated for biomedical purposes and are unavoidably exposed to the blood. Also, nanomaterials may access vascular system after occupational, environmental, or other types of e...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - January 10, 2017 Category: Nanotechnology Authors: Jan Simak, Silvia De Paoli Tags: Advanced Review Source Type: research

Gold nanoparticle ‐mediated photothermal therapy: applications and opportunities for multimodal cancer treatment
Photothermal therapy (PTT), in which nanoparticles embedded within tumors generate heat in response to exogenously applied laser light, has been well documented as an independent strategy for highly selective cancer treatment. Gold‐based nanoparticles are the main mediators of PTT because they offer: (1) biocompatibility, (2) small diameters that enable tumor penetration upon systemic delivery, (3) simple gold‐thiol bioconjugation chemistry for the attachment of desired molecules, (4) efficient light‐to‐heat conversion, and (5) the ability to be tuned to absorb near‐infrared light, which penetrates tissue more de...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - December 31, 2016 Category: Nanotechnology Authors: Rachel S. Riley, Emily S. Day Tags: Focus Article Source Type: research

Reengineering red blood cells for cellular therapeutics and diagnostics
Recently optimized technologies that permit the reversible opening of nanopores across the red blood cell membrane, give the extraordinary opportunity for reengineering human erythrocytes to be used in different biomedical applications, both for therapeutic and diagnostic purposes. Engineered erythrocytes have been exploited as a system for the controlled release of drugs in circulation upon encapsulation of prodrugs or small molecules; as bioreactors when they are endowed of recombinant enzymes able to catalyze the conversion of toxic metabolite into inert products; as drug targeting system for the delivery of compounds t...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - December 31, 2016 Category: Nanotechnology Authors: Francesca Pierig è, Noemi Bigini, Luigia Rossi, Mauro Magnani Tags: Focus Article Source Type: research

Synthetic plant virology for nanobiotechnology and nanomedicine
Nanotechnology is a rapidly expanding field seeking to utilize nano‐scale structures for a wide range of applications. Biologically derived nanostructures, such as viruses and virus‐like particles (VLPs), provide excellent platforms for functionalization due to their physical and chemical properties. Plant viruses, and VLPs derived from them, have been used extensively in biotechnology. They have been characterized in detail over several decades and have desirable properties including high yields, robustness, and ease of purification. Through modifications to viral surfaces, either interior or exterior, plant‐virus�...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - December 31, 2016 Category: Nanotechnology Authors: John F. C. Steele, Hadrien Peyret, Keith Saunders, Roger Castells ‐Graells, Johanna Marsian, Yulia Meshcheriakova, George P. Lomonossoff Tags: Overview Source Type: research

Renal clearable noble metal nanoparticles: photoluminescence, elimination, and biomedical applications
Metal nanoparticles have demonstrated broad and promising biomedical applications in research laboratories, but how to fulfill their promises in the clinical practices demands extensive effort to minimize their non‐specific accumulation in the body. In the past 6 years, we have developed a class of renal clearable noble metal nanoparticles with tunable visible and near‐infrared emission, which can behave like small molecular contrast agents to be effectively eliminated through the kidneys. By taking advantage of the unique clearance pathway, we were able to gain some fundamental understanding of how engineering nanop...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - December 31, 2016 Category: Nanotechnology Authors: Jing Xu, Chuanqi Peng, Mengxiao Yu, Jie Zheng Tags: Overview Source Type: research

Inside Cover Image, Volume 9, Issue 1
The inside cover image, by Hélder Santos et al., is based on the Overview Delivery of therapeutics with nanoparticles: what's new in cancer immunotherapy?, DOI: 10.1002/wnan.1421. The inside cover image, by Hélder Santos et al., is based on the Overview Delivery of therapeutics with nanoparticles: what's new in cancer immunotherapy?, DOI: 10.1002/wnan.1421. (Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - December 28, 2016 Category: Nanotechnology Authors: Flavia Fontana, Dongfei Liu, Jouni Hirvonen, H élder A. Santos Tags: Cover Image Source Type: research

Cover Image, Volume 9, Issue 1
The cover image, by James J. Moon and Yuchen Fan, is based on the Advanced Review Particulate delivery systems for vaccination against bioterrorism agents and emerging infectious pathogens, DOI: 10.1002/wnan.1403. The cover image, by James J. Moon and Yuchen Fan, is based on the Advanced Review Particulate delivery systems for vaccination against bioterrorism agents and emerging infectious pathogens, DOI: 10.1002/wnan.1403. (Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - December 28, 2016 Category: Nanotechnology Authors: Yuchen Fan, James J. Moon Tags: Cover Image Source Type: research

Issue information
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Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - December 20, 2016 Category: Nanotechnology Tags: Issue Information Source Type: research

Cerium oxide nanoparticles in neuroprotection and considerations for efficacy and safety
Cerium oxide nanoparticles have widespread use in the materials industry, and have recently come into consideration for biomedical use due to their potent regenerative antioxidant properties. Given that the brain is one of the most highly oxidative organs in the body, it is subject to some of the greatest levels of oxidative stress, particularly in neurodegenerative disease. Therefore, cerium oxide nanoparticles are currently being investigated for efficacy in several neurodegenerative disorders and have shown promising levels of neuroprotection. This review discusses the basis for cerium oxide nanoparticle use in neurodeg...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - November 7, 2016 Category: Nanotechnology Authors: Beverly A. Rzigalinski, Charles S. Carfagna, Marion Ehrich Tags: Advanced Review Source Type: research

Beyond quantification: in situ analysis of transcriptome and pre ‐mRNA alternative splicing at the nanoscale
In situ analysis offers a venue for dissecting the complex transcriptome in its natural context to tap into cellular processes that could explain the phenotypic physiology and pathology yet to be understood. Over the past decades, enormous progress has been made to improve the resolution, sensitivity, and specificity of single‐cell technologies. The continued efforts in RNA research not only facilitates mechanistic studies of molecular biology but also provides state‐of‐the‐art strategies for diagnostic purposes. The implementation of novel bio‐imaging platforms has yielded valuable information for inspecting gen...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - November 3, 2016 Category: Nanotechnology Authors: Yi Cui, Jing Liu, Joseph Irudayaraj Tags: Advanced Review Source Type: research

Tumor ‐targeted nanotherapeutics: overcoming treatment barriers for glioblastoma
Glioblastoma (GBM) is a highly aggressive and lethal form of primary brain cancer. Numerous barriers exist to the effective treatment of GBM including the tightly controlled interface between the bloodstream and central nervous system termed the ‘neurovascular unit,’ a narrow and tortuous tumor extracellular space containing a dense meshwork of proteins and glycosaminoglycans, and genomic heterogeneity and instability. A major goal of GBM therapy is achieving sustained drug delivery to glioma cells while minimizing toxicity to adjacent neurons and glia. Targeted nanotherapeutics have emerged as promising drug delivery ...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - November 3, 2016 Category: Nanotechnology Authors: Aniket S. Wadajkar, Jimena G. Dancy, David S. Hersh, Pavlos Anastasiadis, Nhan L. Tran, Graeme F. Woodworth, Jeffrey A. Winkles, Anthony J. Kim Tags: Advanced Review Source Type: research

Recent advances in aliphatic polyesters for drug delivery applications
The use of aliphatic polyesters in drug delivery applications has been a field of significant interest spanning decades. Drug delivery strategies have made abundant use of polyesters in their structures owing to their biocompatibility and biodegradability. The properties afforded from these materials provide many avenues for the tunability of drug delivery systems to suit individual needs of diverse applications. Polyesters can be formed in several different ways, but the most prevalent is the ring‐opening polymerization of cyclic esters. When used to form amphiphilic block copolymers, these materials can be utilized to ...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - October 31, 2016 Category: Nanotechnology Authors: Katherine E. Washington, Ruvanthi N. Kularatne, Vasanthy Karmegam, Michael C. Biewer, Mihaela C. Stefan Tags: Overview Source Type: research

Biological and environmental surface interactions of nanomaterials: characterization, modeling, and prediction
The understanding of nano‐bio interactions is deemed essential in the design, application, and safe handling of nanomaterials. Proper characterization of the intrinsic physicochemical properties, including their size, surface charge, shape, and functionalization, is needed to consider the fate or impact of nanomaterials in biological and environmental systems. The characterizations of their interactions with surrounding chemical species are often hindered by the complexity of biological or environmental systems, and the drastically different surface physicochemical properties among a large population of nanomaterials. Th...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - October 31, 2016 Category: Nanotechnology Authors: Ran Chen, Jim E. Riviere Tags: Advanced Review Source Type: research

Complex coacervate ‐based materials for biomedicine
There has been increasing interest in complex coacervates for deriving and transporting biomaterials. Complex coacervates are a dense, polyelectrolyte‐rich liquid that results from the electrostatic complexation of oppositely charged macroions. Coacervates have long been used as a strategy for encapsulation, particularly in food and personal care products. More recent efforts have focused on the utility of this class of materials for the encapsulation of small molecules, proteins, RNA, DNA, and other biomaterials for applications ranging from sensing to biomedicine. Furthermore, coacervate‐related materials have found ...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - October 31, 2016 Category: Nanotechnology Authors: Whitney C. Blocher, Sarah L. Perry Tags: Overview Source Type: research

Status and trends in the development of clinical diagnostic agents
Contrast agents (CA) are routinely used in clinical practice to improve the diagnosis of diseases and to monitor therapy response. The majority of CA comprises small molecules accumulating at pathological sites due to vascular abnormalities, such as changes in perfusion and permeability. For many diseases, high diagnostic accuracy can be achieved with contrast‐enhanced imaging. This means that new CA will only succeed in translation if they either show superior performance with respect to diagnostic accuracy, safety and cost, support a new imaging modality, or are directly linked to the refinement of therapy, e.g., as a ...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - October 31, 2016 Category: Nanotechnology Authors: Tatjana Opacic, Vera Paefgen, Twan Lammers, Fabian Kiessling Tags: Advanced Review Source Type: research