The International Journal of Lower Extremity Wounds This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A Huge Morel-Lavallee Lesion Treated Using a Quilting Suture Method: A Case Report and Review of the Literature
We present a case of a huge recurrent Morel-Lavallée lesion in the lower back and buttock region that was treated with quilting sutures, fibrin sealant, and compression, with a review of the literature. (Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - June 13, 2014 Category: Surgery Authors: Seo, B. F., Kang, I. S., Jeong, Y. J., Moon, S. H. Tags: Case Report Source Type: research

Successful Treatment of a Patient With Complicated Diabetic Foot Wound: A Case Report
This article reports a complicated diabetic patient with severe limb-threatening necrotizing infection. We successfully applied endovascular stent insertion, digit amputation, negative pressure wound therapy, and advanced dressings in different wound phases to achieve definitive wound healing after 12 months of treatment. Based on this case report, we would like to emphasize the importance of combined multiple therapies and patient compliance for severe diabetic foot ulcers. (Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - June 13, 2014 Category: Surgery Authors: Zheng, Y., Wang, X., Zhang, L., You, C., Feng, Z., Han, C. Tags: Case Report Source Type: research

Maggot Therapy for Elephantiasis Nostras Verrucosa Reveals New Applications and New Complications: A Case Report
We report novel therapy for ENV with maggot debridement therapy (MDT), an effective wound therapy that has gained popularity with the rise of antimicrobial resistance. MDT, in combination with tangential surgical debridement, was effective in the treatment of ENV. In nature, sheep infested with more than 16 000 blow fly larvae exhibit ammonia toxicity. Although hyperammonemia as a side effect of maggot therapy has been theorized, its existence has not been described in human studies until this case. This patient exhibited hyperammonemia during maggot therapy; with alterations in serum ammonia reflecting changes in larval p...
Source: The International Journal of Lower Extremity Wounds - June 13, 2014 Category: Surgery Authors: Borst, G. M., Goettler, C. E., Kachare, S. D., Sherman, R. A. Tags: Case Report Source Type: research

Elevated Levels of Coagulation Factor VIII in Patients With Venous Leg Ulcers
We report 3 patients with chronic leg ulcers and high levels of FVIII:C activity in plasma and other associated thrombophilic factors. We highlight the need to get a workup done for thrombophilia in young patients with recurrent and chronic leg ulcers related to venous insufficiency or livedoid vasculopathy. Further studies with larger sample sizes are required to define the definite indications for the thrombophilia workups. (Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - June 13, 2014 Category: Surgery Authors: Criado, P. R., Alavi, A., Kirsner, R. S. Tags: Case Report Source Type: research

A CD30(-) Transformed Mycosis Fungoides Case Responding Very Well to Systemic Bexarotene and Methotrexate
The course of mycosis fungoides (MF) is indolent except when transformation to a large T-cell lymphoma occurs. The diagnosis of transformed MF relies on the presence of more than 25% of large cells on biopsy of an MF lesion. Treatment of transformed MF is a major challenge as these patients have poor outcome. Here, we report a 61-year-old man presenting with tumoral ulcer on the plantar area of the foot who was diagnosed cutaneous CD30(–) large cell transformed MF and treated with systemic methotraxate and bexarotene therapy. (Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - June 13, 2014 Category: Surgery Authors: Zindanci, I., Kavala, M., Turkoğlu, Z., Can, B., Ozturk, E., Zemheri, E., Akbulak, O., Mansuroglu, C., Topaloğlu Demir, F. Tags: Case Report Source Type: research

Autologous Platelet Gel: Five Cases Illustrating Use on Sickle Cell Disease Ulcers
Leg ulcers represent a particularly disabling complication in patients with sickle cell disease (SCD). Platelet gel (PG) is a novel therapeutic strategy used for accelerating wound healing of a wide range of tissues through the continuous release of platelet growth factors. Here, we describe the use of PG preparation according to Anitua’s PRGF (preparations rich in growth factors) protocol for treating chronic nonhealing ulcers in patients with SCD. A positive response occurred in 3 patients with an area reduction of 85.7% to 100%, which occurred within 7 to 10 weeks, and a 35.2% and 20.5% of area reduction in 2 othe...
Source: The International Journal of Lower Extremity Wounds - June 13, 2014 Category: Surgery Authors: Gilli, S. C. O., do Valle Oliveira, S. A., Saad, S. T. O. Tags: Clinical and Translational Research Source Type: research

Quantitative Evaluation of Maceration in Venous Leg Ulcers by Transepidermal Water Loss (TEWL) Measurement
Skin maceration is a clinical manifestation in venous leg ulcers that leads to severe consequences for patients’ quality of life and wound management. The aim of this study was to explore the use of transepidermal water loss (TEWL) measurement technique to quantify different level of surrounding skin maceration in patients with venous leg ulcers. A total of 50 patients were recruited and TEWL measurements were taken with a portable device on different locations surrounding the leg ulcer and on control skin. A clinical score for maceration was used and correlated to the involvement of surrounding skin. Statistically s...
Source: The International Journal of Lower Extremity Wounds - June 13, 2014 Category: Surgery Authors: Dini, V., Barbanera, S., Romanelli, M. Tags: Clinical and Translational Research Source Type: research

Baropodometric Evaluations and Sensitivity Alterations in Plantar Ulcer Formation in Leprosy
Leprosy is a chronically evolving granulomatous disease caused by the bacillus Mycobacterium leprae, which exhibits tropism for peripheral and motor nerves and slow-growing inflammation that affects the peripheral nervous system, especially the sensory fibers. The aim of this study was to observe the relationship between peak pressure and abnormal sensitivity for the formation of plantar ulcers in patients with multibacillary (MB) and paucibacillary (PB) leprosy. A total of 51 individuals with leprosy were evaluated and classified as either MB or PB and then submitted to the Semmes-Weinstein sensitivity test; 20 normal ind...
Source: The International Journal of Lower Extremity Wounds - June 13, 2014 Category: Surgery Authors: Cordeiro, T. L., Frade, M. A. C., Barros, A. R. S. B., Foss, N. T. Tags: Clinical and Translational Research Source Type: research

Sulodexide as Adjunctive Therapy in Diabetic Foot Patients With Critical Limb Ischemia Treated With Percutaneous Transluminal Angioplasty
We evaluated the safety and efficacy of sulodexide, a biocompound of glycosamin-glicans, as adjunct medical therapy to percutaneous transluminal angioplasty (PTA) in diabetes mellitus (DM) patients with critical limb ischemia (CLI). We studied 27 consecutive DM patients with CLI successfully subjected to PTA who, on top of standard antiplatelet therapy, received sulodexide 25 mg bid, and were followed-up for 24 weeks, monitoring adverse events, transcutaneous oxygen tension (TcPO2), ankle–brachial pressure index, pain, and ulcer dimension. At the end of follow-up, ulcer healing, amputation rates, and cardiovascular r...
Source: The International Journal of Lower Extremity Wounds - June 13, 2014 Category: Surgery Authors: Piaggesi, A., Abbruzzese, L., Mattaliano, C., Bargellini, I., Cicorelli, A., Iacopi, E., Lunardi, A., Coppelli, A., Goretti, C., Cioni, R. Tags: Clinical and Translational Research Source Type: research

Differential Expression of Matrix Metalloproteinase-9 Gene in Wounds of Type 2 Diabetes Mellitus Cases With Susceptible -1562C>T Genotypes and Wound Severity
In conclusion, The risk genotypes of -1562 C>T polymorphism along with lack of methylation of CpG sites in MMP9 gene promoter may result in altered expression of MMP9 in wounds of T2DM cases resulting into nonhealing chronic ulcers in them. (Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - June 13, 2014 Category: Surgery Authors: Singh, K., Agrawal, N. K., Gupta, S. K., Mohan, G., Chaturvedi, S., Singh, K. Tags: Basic and Experimental Research Source Type: research

Angiogenic Effect of Mesenchymal Stem Cells as a Therapeutic Target for Enhancing Diabetic Wound Healing
This article reviews the recent literatures on MSCs treatment for promoting angiogenesis or vascularization in diabetic wounds and the potential mechanisms involved, with an emphasis on the role of paracrine soluble factors. Meanwhile, the potential benefits and related risks associated with the therapeutic use of MSCs have been presented and may lead to better understanding of the influence of MSCs without increasing potential risks. Further investigation will be required to determine the molecular basis of paracrine mechanisms and regulated angiogenesis of MSCs for its rational manipulation for impaired angiogenesis repa...
Source: The International Journal of Lower Extremity Wounds - June 13, 2014 Category: Surgery Authors: Gu, C., Huang, S., Gao, D., Wu, Y., Li, J., Ma, K., Wu, X., Fu, X. Tags: Original Review Source Type: research

Wound Care Study and Translation Application: A Team's Work in China
Trauma, tissue repair, and regeneration are frontier research areas in China and a team led by Professor Xiaobing Fu has become an important unit in this field in China. Over the past years, this team has played a key role in wound prevention, management, and some regulation making at the state level. The works on functions of growth factor and the action of these functions in regulating wound healing, stem cell biology, and its application for sweat gland regeneration, education, or training and prevention for chronic skin wounds are outstanding. (Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - June 13, 2014 Category: Surgery Authors: Fu, X. Tags: Guest Editorial Source Type: research

Editorial
(Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - June 13, 2014 Category: Surgery Authors: Mani, R. Tags: Editorial Source Type: research

Free-Style Dual Plane Recycling Tensor Fascia Lata Musculocutaneous Perforator Flap for Reconstruction of Recurrent Trochanteric Defects
This article presents the concept of free-style recycling of a tensor fascia lata flap into a perforator-based flap separated in 2 planes in a patient with a recurrent bilateral trochanteric defect. If a reliable perforator is preserved and identified within the tissues by computed tomography angiography or a Doppler device, a new perforator flap can be designed and raised at the previous flap site. (Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - March 21, 2014 Category: Surgery Authors: Han, B. L., Choi, H. J. Tags: Case Report Source Type: research

Clinical Characteristics and Risk Factors of Diabetic Foot Ulcer With Multidrug-Resistant Organism Infection
The objective was to determine multidrug-resistant organisms’ (MDROs) profile in diabetic foot ulcers (DFU), antibiotic resistance of MDROs, and to find the potential risk factors for infection with MDROs. In 157 patients with DFU admitted to Tianjin Metabolic Disease Hospital, China, from January 2011 to January 2012, microbiological specimens were taken on admission. The patients were divided into 2 groups according to the infection of MDROs. Potential risk factors for MDRO-positive specimens were examined using univariate and multivariate analyses. Seventy-eight MDRO strains were isolated from patients in the MDRO...
Source: The International Journal of Lower Extremity Wounds - March 21, 2014 Category: Surgery Authors: Ji, X., Jin, P., Chu, Y., Feng, S., Wang, P. Tags: Basic and Experimental Research Source Type: research