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Promising Role of ANGPTL4 Gene in Diabetic Wound Healing
This article will therefore focus on the efficacy of ANGPTL4 (angiopoietin-like 4) gene, which plays a novel role in keratinocyte migration during wound healing. (Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - March 21, 2014 Category: Surgery Authors: Arya, A. K., Tripathi, K., Das, P. Tags: Basic and Experimental Research Source Type: research

Wound Healing Activity of the Inflorescence of Typha elephantina (Cattail)
Methanolic extracts of Typha elephantina inflorescence (TE) and its bandage were screened for wound healing by incision and excision wound models in Wistar rats. In the incision wound model, incision wounds were topically treated with TE gel (2.0% [w/w], 3.0% [w/w], and 5.0% [w/w]), Typha elephantina inflorescence bandage, and the reference standard 5.0% w/w povidone iodine for a period of 10 days. When the wounds healed thoroughly, sutures were removed on the 8th postwounding day, and the tensile strength of the skin was measured on the 10th day. In the excision wound model, excision wounds were treated with TE gel (3.0% ...
Source: The International Journal of Lower Extremity Wounds - March 21, 2014 Category: Surgery Authors: Panda, V., Thakur, T. Tags: Basic and Experimental Research Source Type: research

Pharmacological Evaluation and Chemical Standardization of an Ayurvedic Formulation for Wound Healing Activity
Wound healing is a topic of substantial prominence in Ayurveda, the Indian traditional system of medicine. Test drug Kshatantak Malam (KM), otherwise named as Baharer Nani, is described in Ayurveda since a long time for wound healing activity but necessitates scientific base. The test drug was prepared in the form of natural ointment with the plants like Achyranthes aspera, Allium cepa, and Canabis sativa under the base of butter in a specialized form of preparation. Chemical standardization was made on the basis of the physical character, rancidity test, extractive value, thin-layer chromatography, and gas chromatography....
Source: The International Journal of Lower Extremity Wounds - March 21, 2014 Category: Surgery Authors: Gangopadhyay, K. S., Khan, M., Pandit, S., Chakrabarti, S., Mondal, T. K., Biswas, T. K. Tags: Basic and Experimental Research Source Type: research

Outcomes After 294 Transtibial Amputations With the Posterior Myocutaneous Flap
The transtibial amputation is a common operation for which there is little agreement regarding which technique provides the most reliable and resilient outcomes. We performed a retrospective chart review of all transtibial amputations performed by a single surgeon between 2004 and 2011 using the posterior myocutaneous flap with triceps surae myodesis technique. A stepwise logistic regression analysis was performed to evaluate the association between independent variables and dependent outcome variables. A total of 270 patients with 294 transtibial amputations were identified. Ambulation data were available for 192 patients...
Source: The International Journal of Lower Extremity Wounds - March 21, 2014 Category: Surgery Authors: Brown, B. J., Iorio, M. L., Klement, M., Conti Mica, M. R., El-Amraoui, A., O'Halloran, P., Attinger, C. E. Tags: Translational Research Source Type: research

The Influence of the Length of the First Metatarsal on the Risk of Reulceration in the Feet of Patients With Diabetes
Our aim was to identify the optimal diagnostic cutoff point on the scale of protrusion measurements of the first metatarsal (M1) to predict the probability of reulceration after metatarsal head resection in patients with diabetes mellitus. We conducted a prospective study of patients with diabetes who underwent resection of at least 1 metatarsal head in our department. After surgery, we measured the difference in length (protrusion) between the M1 and the longest of the 4 lesser metatarsals by radiographic view. The patients were divided into those in whom the M1 was the longest of the 5 metatarsals (group 1) and patients ...
Source: The International Journal of Lower Extremity Wounds - March 21, 2014 Category: Surgery Authors: Molines-Barroso, R. J., Lazaro-Martinez, J. L., Aragon-Sanchez, J., Garcia-Morales, E., Carabantes-Alarcon, D., Alvaro-Afonso, F. J. Tags: Translational Research Source Type: research

Reducing Major Lower Extremity Amputations After the Introduction of a Multidisciplinary Team for the Diabetic Foot
This study demonstrates that the introduction of a multidisciplinary team, coordinated by an endocrinologist and a podiatrist, for managing diabetic foot disease is associated with a reduction in the incidence of major amputations in patients with diabetes. (Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - March 21, 2014 Category: Surgery Authors: Rubio, J. A., Aragon-Sanchez, J., Jimenez, S., Guadalix, G., Albarracin, A., Salido, C., Sanz-Moreno, J., Ruiz-Grande, F., Gil-Fournier, N., Alvarez, J. Tags: Translational Research Source Type: research

Clinical Characteristics and Medical Costs in Patients With Diabetic Amputation and Nondiabetic Patients With Nonacute Amputation in Central Urban Hospitals in China
The objective was to analyze the clinical characteristics, amputation level, final outcome of amputation, and medical cost between diabetic amputation and nonacute amputation in China central urban hospitals. For year 2010, amputation data from 19 central municipal general hospitals located in different big cities in China were retrospectively analyzed according to a standardized protocol. A total of 308 amputation patients were recruited. The patients were divided into diabetic amputation group (n = 174) and nonacute amputation group (n = 134). A total of 27.3% of the amputated patients or 56.5% of the nonacute patients w...
Source: The International Journal of Lower Extremity Wounds - March 21, 2014 Category: Surgery Authors: Wang, A., Xu, Z., Mu, Y., Ji, L. Tags: Translational Research Source Type: research

Effect of Daptomycin on Local Interleukin-6, Matrix Metalloproteinase-9, and Metallopeptidase Inhibitor 1 in Patients With MRSA-Infected Diabetic Foot
Infection is a major cause of the diabetic foot syndrome that is promoted by the increased burden of multiresistant germs like methicillin-resistant Staphylococcus aureus (MRSA). Maximizing positive outcome for serious MRSA infections requires an aggressive treatment approach and careful monitoring of the healing process. Therefore, we examined 8 patients with MRSA-infected diabetic foot syndrome of Wagner classification grade 2 or 3 (corresponding to the Texas classification stage 2 or 3) during antibiotic treatment with daptomycin. We documented the wound size and obtained samples of wound secretion for analyses of proin...
Source: The International Journal of Lower Extremity Wounds - March 21, 2014 Category: Surgery Authors: Ambrosch, A., Halevy, D., Fwity, B., Brin, T., Lobmann, R. Tags: Clinical Research Source Type: research

Translation and Validation of the Chinese Cardiff Wound Impact Schedule
The objectives of the study were to translate the Cardiff Wound Impact Schedule (CWIS), a disease-specific quality-of-life measure, into Chinese, and to evaluate its psychometric properties. The CWIS went through the full linguistic translation process and was evaluated in patients with current diabetic foot ulcers (DFU). Patients were categorized using the Wagner grade. Mean CWIS scores were compared between categories to evaluate the scale’s ability to differentiate ulcer severity (Wagner grade). There were a total of 131 consecutive patients included in the study. Except item A22 (I am confident that the wound I h...
Source: The International Journal of Lower Extremity Wounds - March 21, 2014 Category: Surgery Authors: Huang, Y., Wu, M., Xing, P., Xie, T., Cao, Y., Qian, P., Ruan, H. Tags: Clinical Research Source Type: research

We Must Work Together to Provide a Better Solution
(Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - March 21, 2014 Category: Surgery Authors: Hong, J. P. Tags: Guest Editorial Source Type: research

A Mild Wet Winter
(Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - March 21, 2014 Category: Surgery Authors: Mani, R. Tags: Editorial Source Type: research

Reviewer List: IJLEW says Thanks to its Reviewers 2013
(Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - December 17, 2013 Category: Surgery Tags: News Source Type: research

Topical Application of Silver Nitrate
(Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - December 17, 2013 Category: Surgery Authors: Asaad, K., Mashhadi, S. Tags: Letter to the Editor Source Type: research

Lower Extremity Amputation: A Complete Series From a Tertiary Hospital
(Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - December 17, 2013 Category: Surgery Authors: Jindeel, A., Narahara, K. A. Tags: Letter to the Editor Source Type: research

Elephantasis Nostras Verrucosa and Psoriasis: Only a Coincidence?
(Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - December 17, 2013 Category: Surgery Authors: Savoia, F., Odorici, G., Tengattini, V., Patrizi, A., Gaddoni, G. Tags: Letter to the Editor Source Type: research