Infection, Immune Disorders, Hemoglobinopathies, and Lower Extremity Wounds: Are We Doing Enough?
(Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - October 9, 2015 Category: Surgery Authors: Rerkasem, K., Mani, R. Tags: Editorial Source Type: research

Wound Documentation by Using 3G Mobile as Acquisition Terminal: An Appropriate Proposal for Community Wound Care
The increasing numbers of cases of wound disease are now posing a big challenge in China. For more convenience of wound patients, wound management in community health care centers under the supervision of a specialist at general hospitals is an ideal solution. To ensure an accurate diagnosis in community health clinics, it is important that "the same language" for wound description, which may be composed of unified format description, including wound image, must be achieved. We developed a wound information management system that was built up by acquisition terminal, wound description, data bank, and related software. In t...
Source: The International Journal of Lower Extremity Wounds - July 17, 2015 Category: Surgery Authors: Ge, K., Wu, M., Liu, H., Gong, J., Zhang, Y., Hu, Q., Fang, M., Tao, Y., Cai, M., Chen, H., Wang, J., Xie, T., Lu, S. Tags: Technical Report Source Type: research

Epidermolysis Bullosa Pruriginosa: Case Series and Review of the Literature
In this report, we describe 3 cases of EB pruriginosa and review the current literature. (Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - July 17, 2015 Category: Surgery Authors: Kim, W. B., Alavi, A., Pope, E., Walsh, S. Tags: Case Series and Case Reports Source Type: research

Partial Removal of Nail Matrix in the Treatment of Ingrown Nails: Prospective Randomized Control Study Between Curettage and Electrocauterization
The aim of this study was to compare the result of electrocauterization and curettage, which can be done with basic instruments. Patients with ingrown nail were randomized to 2 groups. In the first group, nail matrix was removed by curettage, and the second group, nail matrix was removed by electrocautery. A total of 61 patients were enrolled; 32 patients were operated by curettage, and 29 patients were operated by electrocautery. Wound infections, as early complication, were found in 15.6% (5/32) of the curettage group, 10.3% (3/29) of the electrocautery group patients each (P = .710). Nonrecurrence was observed in 93.8% ...
Source: The International Journal of Lower Extremity Wounds - July 17, 2015 Category: Surgery Authors: Kim, M., Song, I.-G., Kim, H. J. Tags: Case Series and Case Reports Source Type: research

Propylthiouracil-Induced Vasculitis With Antineutrophil Cytoplasmic Antibody
We report a case of perinuclear antineutrophil cytoplasmic antibody–associated vasculitis developed during treatment with PTU for Grave’s disease. (Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - July 17, 2015 Category: Surgery Authors: Criado, P. R., Grizzo Peres Martins, A. C., Gaviolli, C. F., Alavi, A. Tags: Case Series and Case Reports Source Type: research

Clinical Examination and Treatment of a Leg Ulcer Caused by a Stingray Puncture
The most frequent causes of leg ulcers include venous incompetency (superficial and deep), arterial insufficiency, trauma, vasculitis, and neoplasm. Leg ulcers from injury by stingrays are quite rare. In this case report, we describe a leg ulcer caused by a stingray sting complicated by infection, which healed completely without surgery. In addition, since there few cases in the literature describing such traumas, we performed a comprehensive review of the literature. Important is the fact that the wound healing was complete without resorting to surgery, but only with a correct targeted antibiotic therapy and the use of a ...
Source: The International Journal of Lower Extremity Wounds - July 17, 2015 Category: Surgery Authors: Fino, P., Onesti, M. G., Felli, A., Scuderi, N. Tags: Case Series and Case Reports Source Type: research

Bacteriological Investigation of Chronic Wounds in a Specialized Wound Healing Department: A Retrospective Analysis of 107 Cases
In conclusion, the microbial characteristics were mostly in the site of lower extremity, gram-negative bacteria, and monopathogen, respectively. Furthermore, the relationship between the wound culture result and chronic wound infection was not exactly coincident. It may be useful for guiding the empiric therapy of chronic wounds. (Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - July 17, 2015 Category: Surgery Authors: Wu, M., Ruan, H., Huang, Y., Liu, C., Ni, P., Ye, J., Lu, S., Xie, T. Tags: Case Series and Case Reports Source Type: research

HbA1c and Lower Extremity Amputation Risk in Patients With Diabetes: A Meta-Analysis
In this meta-analysis, we aimed to assess glycosylated hemoglobin (HbA1c) level and lower extremity amputation (LEA) risk in patients with diabetes. Systematic computerized searches of the PubMed and Web of Knowledge were performed. We compared HbA1c level between groups with LEA and without LEA by meta-analysis; we also examined the dose–response relationship between HbA1c level and LEA risk. Sixteen studies were included in the meta-analysis. Eleven studies with 43 566 patients compared HbA1c between groups with and without LEA. The mean HbA1c (%) ranged from 8.3 to 12.5 in the group with LEA and from 7.4 to 11.3 i...
Source: The International Journal of Lower Extremity Wounds - July 17, 2015 Category: Surgery Authors: Zhou, Z.-Y., Liu, Y.-K., Chen, H.-L., Yang, H.-L., Liu, F. Tags: Clinical and Translational Research Source Type: research

Changes in Bacterial Profiles and Antibiotic Sensitivity Before and After Wound Bed Preparation for Diabetic Foot Ulcers
In conclusion, following wound bed preparation for diabetic foot ulcers, MDR bacteria numbers were increased and antibiotic sensitivity was decreased; inflammation was decreased. These findings warrant future studies for confirmation. (Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - July 17, 2015 Category: Surgery Authors: Wang, G., Tian, J., Zhu, L.-y., Yang, S., Ding, Y., Kang, Y., Wang, F., Wang, Y., Dong, Y., Li, Y., Xu, X. Tags: Clinical and Translational Research Source Type: research

Analysis of Ulcer Recurrences After Metatarsal Head Resection in Patients Who Underwent Surgery to Treat Diabetic Foot Osteomyelitis
Metatarsal head resection is a common and standardized treatment used as part of the surgical routine for metatarsal head osteomyelitis. The aim of this study was to define the influence of the amount of the metatarsal resection on the development of reulceration or ulcer recurrence in patients who suffered from plantar foot ulcer and underwent metatarsal surgery. We conducted a prospective study in 35 patients who underwent metatarsal head resection surgery to treat diabetic foot osteomyelitis with no prior history of foot surgeries, and these patients were included in a prospective follow-up over the course of at least 6...
Source: The International Journal of Lower Extremity Wounds - July 17, 2015 Category: Surgery Authors: Sanz-Corbalan, I., Lazaro-Martinez, J. L., Aragon-Sanchez, J., Garcia-Morales, E., Molines-Barroso, R., Alvaro-Afonso, F. J. Tags: Clinical and Translational Research Source Type: research

Alginate and DNA Gels Are Suitable Delivery Systems for Diabetic Wound Healing
In this study, we tested the efficacy of novel biomaterials in improving wound healing in mouse models of diabetes mellitus (DM). The biomaterials are composed of alginate- and deoxyribonucleic acid (DNA)-based gels that allow incorporation of effector cells, such as outgrowth endothelial cells (OEC), and provide sustained release of bioactive factors, such as neuropeptides and growth factors, which have been previously validated in experimental models of DM wound healing or hind limb ischemia. We tested these biomaterials in mice and demonstrate that they are biocompatible and can be injected into the wound margins withou...
Source: The International Journal of Lower Extremity Wounds - July 17, 2015 Category: Surgery Authors: Tellechea, A., Silva, E. A., Min, J., Leal, E. C., Auster, M. E., Pradhan-Nabzdyk, L., Shih, W., Mooney, D. J., Veves, A. Tags: Basic and Experimental Research Source Type: research

Transdifferentiation of Umbilical Cord-Derived Mesenchymal Stem Cells Into Epidermal-Like Cells by the Mimicking Skin Microenvironment
In conclusion, manipulating the 3D microenvironment is a novel method for inducing the epidermal differentiation of MSCs to engineer epidermal substitutes, which provides an alternative strategy for skin tissue engineering. (Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - July 17, 2015 Category: Surgery Authors: Chen, D., Hao, H., Tong, C., Liu, J., Dong, L., Ti, D., Hou, Q., Liu, H., Han, W., Fu, X. Tags: Basic and Experimental Research Source Type: research

Underrecognized Peripheral Arterial Disease in Patients With Diabetes Mellitus in Thailand: We Must Consider Neuroischemic Foot Ulcers From This Fallout
A range of prevalence of peripheral artery disease in diabetic patients has been estimated using the measurement of ankle brachial pressure index and clinical features in Asian countries. These data may be underestimates and hence underrecognized, raising questions about the numbers of patients with neuroischemic feet who are also at risk of diabetic foot ulcers. Underrecognition of these lesions may well increase the high levels of chronic wound burden resulting from peripheral artery disease as well as neuroischemic foot lesions. Improved education and training of clinical staff (nurses and family physicians) is required...
Source: The International Journal of Lower Extremity Wounds - July 17, 2015 Category: Surgery Authors: Rerkasem, K., Kosachunhanun, N., Sony, K., Inpankaew, N., Mani, R. Tags: Reviews Source Type: research

Conservative Surgery of Diabetic Forefoot Osteomyelitis: How Can I Operate on This Patient Without Amputation?
Surgery is necessary in many cases of diabetic foot osteomyelitis. The decision to undertake surgery should be based on the clinical presentation of diabetic foot osteomyelitis. Surgery is required when the bone is protruding through the ulcer, there is extensive bone destruction seen on x-ray or progressive bone damage on sequential x-ray while undergoing antibiotic treatment, the soft tissue envelope is destroyed, and there is gangrene or spreading soft tissue infection. Several issues should be taken into account when considering surgery for treating diabetic foot osteomyelitis. It is necessary to have a surgeon availab...
Source: The International Journal of Lower Extremity Wounds - July 17, 2015 Category: Surgery Authors: Aragon-Sanchez, J., Lazaro-Martinez, J. L., Alvaro-Afonso, F. J., Molines-Barroso, R. Tags: Reviews Source Type: research

Glycated Hemoglobin as a Risk Factor for Lower Extremity Amputations in Diabetes: "Success Is Counted Sweetest"
(Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - July 17, 2015 Category: Surgery Authors: Papanas, N., Maltezos, E. Tags: Guest Editorial Source Type: research