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Summer Time
(Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - July 17, 2015 Category: Surgery Authors: Rerkasem, K., Mani, R. Tags: Editorial Source Type: research

In Remembrance of George W. Cherry (1940-2015)
(Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - July 17, 2015 Category: Surgery Authors: Terence, R. Tags: Obituary Source Type: research

Thank You Reviewers From IJLEW
(Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - April 8, 2015 Category: Surgery Tags: Reviewer Acknowledgment Source Type: research

Rare Complication of Silicone Fluid Injection Presenting as Multiple Calcification and Skin Defect in Both Legs: A Case Report
This article aims to demonstrate the diagnosis and treatment of multiple calcification and skin defect after silicone fluid injection for soft tissue augmentation. A 65-year-old female presented with skin defect and calcifications had been steadily increasing in size over a 3-month period. Examination confirmed pain, swelling, induration, and 5 x 5 cm sized skin defect with marginal and adjacent calcification in the left lateral malleolar area. She had been injected silicone fluid for soft tissue of lower extremity augmentation and contouring 30 years ago. Serial surgical debridement of this entire zone of calcification an...
Source: The International Journal of Lower Extremity Wounds - April 8, 2015 Category: Surgery Authors: Lee, J. H., Choi, H. J. Tags: Case Reports Source Type: research

A Case of Prolidase Deficiency Accompanying Leg Ulcers
We present this rare case to draw attention to consider prolidase deficiency in the differential diagnosis of leg ulcers. (Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - April 8, 2015 Category: Surgery Authors: Solak, B., Kara, R. O., Erdem, T., Muftuoglu, T. Tags: Case Reports Source Type: research

Local Antibiotic Delivery Systems in Diabetic Foot Osteomyelitis: Time for One Step Beyond?
In patients with diabetes mellitus, osteomyelitis is a severe, difficult-to-treat form of foot infection. In the management of diabetic foot osteomyelitis, carriers for local delivery of antimicrobial agents have begun to be tried, in an attempt to provide high local antibiotic concentrations. Randomized clinical trials are now expected to clarify when this new approach should be used and how it can be integrated into the overall therapeutic strategy for diabetic foot osteomyelitis. (Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - April 8, 2015 Category: Surgery Authors: Panagopoulos, P., Drosos, G., Maltezos, E., Papanas, N. Tags: Review Source Type: research

Mesenchymal Stem Cell-Conditioned Medium Improves the Proliferation and Migration of Keratinocytes in a Diabetes-Like Microenvironment
In this study, we explored the effects of diabetes-like microenvironment with high glucose (HG) and intense inflammation on the migration and proliferation of keratinocytes in vitro. We found that the migration and proliferation of rat keratinocytes were reduced with HG and lipopolysaccharide (LPS) stimulation via Erk signaling pathway in a reactive oxygen species (ROS)-dependent manner. Nevertheless, mesenchymal stem cell–conditioned medium (MSC-CM) counteracts the effects of HG and LPS. Treatment of rat keratinocyte with MSC-CM decreased HG- and/or LPS-induced ROS overproduction. Furthermore, MSC-CM reversed the do...
Source: The International Journal of Lower Extremity Wounds - April 8, 2015 Category: Surgery Authors: Li, M., Zhao, Y., Hao, H., Dai, H., Han, Q., Tong, C., Liu, J., Han, W., Fu, X. Tags: Basic and Experimental Research Source Type: research

Hypoxia Regulates the Therapeutic Potential of Mesenchymal Stem Cells Through Enhanced Autophagy
In conclusion, hypoxia pretreatment enhances survival in BM-MSCs, promoting angiogenesis by increasing autophagy and significantly decreasing apoptosis. Therefore, modulation of autophagy with hypoxic pretreatment may provide a novel strategy to improve MSC-based therapies. (Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - April 8, 2015 Category: Surgery Authors: Liu, J., Hao, H., Huang, H., Tong, C., Ti, D., Dong, L., Chen, D., Zhao, Y., Liu, H., Han, W., Fu, X. Tags: Basic and Experimental Research Source Type: research

Mesenchymal Stem Cells Suppress Fibroblast Proliferation and Reduce Skin Fibrosis Through a TGF-{beta}3-Dependent Activation
Recent studies showed that transplantation of mesenchymal stem cells (MSCs) significantly decreased tissue fibrosis; however, little attention has been paid to its efficacy on attenuating skin fibrosis, and the mechanism involved in its effect is poorly understood. In this work, we investigated the effects of MSCs on keloid fibroblasts and extracellular matrix deposition through paracrine actions and whether the antifibrotic properties of MSCs involved transforming growth factor-β (TGF-β)-dependent activation. In vitro experiments showed that conditioned media (CM) from MSCs decreased viability, a-smooth muscle a...
Source: The International Journal of Lower Extremity Wounds - April 8, 2015 Category: Surgery Authors: Wu, Y., Peng, Y., Gao, D., Feng, C., Yuan, X., Li, H., Wang, Y., Yang, L., Huang, S., Fu, X. Tags: Basic and Experimental Research Source Type: research

Infections of Diabetic Foot Ulcers With Methicillin-Resistant Staphylococcus aureus
Infected diabetic foot is the most common reason for hospitalization and complications in patients with type 2 diabetes mellitus (DM2). Methicillin-resistant Staphylococcus aureus (MRSA) is frequently isolated from such lesions, and its presence is growing, seriously deteriorating the infected patient’s quality of life. The aim of this study was to assess the prevalence of MRSA as well as other microbiota in 100 patients diagnosed with (DM2) and with infected foot ulcers at the Hospital General de Mexico. The main results obtained show a prevalence of Staphylococcus aureus (42%), followed by Escherichia coli (36%) an...
Source: The International Journal of Lower Extremity Wounds - April 8, 2015 Category: Surgery Authors: Cervantes-Garcia, E., Garcia-Gonzalez, R., Resendiz-Albor, A., Salazar-Schettino, P. M. Tags: Clinical and Translational Research Source Type: research

Healing Rate and Autoimmune Safety of Full-Thickness Wounds Treated With Fish Skin Acellular Dermal Matrix Versus Porcine Small-Intestine Submucosa: A Noninferiority Study
A novel product, the fish skin acellular dermal matrix (ADM) has recently been introduced into the family of biological materials for the treatment of wounds. Hitherto, these products have been produced from the organs of livestock. A noninferiority test was used to compare the effect of fish skin ADM against porcine small-intestine submucosa extracellular matrix in the healing of 162 full-thickness 4-mm wounds on the forearm of 81 volunteers. The fish skin product was noninferior at the primary end point, healing at 28 days. Furthermore, the wounds treated with fish skin acellular matrix healed significantly faster. These...
Source: The International Journal of Lower Extremity Wounds - April 8, 2015 Category: Surgery Authors: Baldursson, B. T., Kjartansson, H., Konradsdottir, F., Gudnason, P., Sigurjonsson, G. F., Lund, S. H. Tags: Clinical and Translational Research Source Type: research

The Association Between Skin Autofluorescence and Vascular Complications in Chinese Patients With Diabetic Foot Ulcer: An Observational Study Done in Shanghai
In conclusion, SAF, reflecting tissue accumulation of AGEs, is independently associated with the presence of vascular complications in DFU patients. (Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - April 8, 2015 Category: Surgery Authors: Liu, C., Xu, L., Gao, H., Ye, J., Huang, Y., Wu, M., Xie, T., Ni, P., Yu, X., Cao, Y., Lu, S. Tags: Clinical and Translational Research Source Type: research

Epidemiology of Type 2 Diabetic Foot Problems and Predictive Factors for Amputation in China
To determine incidence and clinically relevant risk factors for diabetic amputation in a large cohort study of diabetic foot ulceration patients in China, we investigated a total of 669 diabetic foot ulceration patients, who were assessed at baseline for demographic information, medical and social history, peripheral neuropathy screening, periphery artery disease screening, assessment of nutritional status and diabetic control, physical examination including foot deformity in 15 Grade III-A hospitals. Of the 669 patients, 435 were male and 201 were female, with the mean age being 64.0 years. Of all patients, 110 had neurop...
Source: The International Journal of Lower Extremity Wounds - April 8, 2015 Category: Surgery Authors: Jiang, Y., Ran, X., Jia, L., Yang, C., Wang, P., Ma, J., Chen, B., Yu, Y., Feng, B., Chen, L., Yin, H., Cheng, Z., Yan, Z., Yang, Y., Liu, F., Xu, Z. Tags: Clinical and Translational Research Source Type: research

Liver Enzymes and Lipid Levels in Patients With Lipodermatosclerosis and Venous Ulcers Treated With a Prototypic Anabolic Steroid (Stanozolol): A Prospective, Randomized, Double-Blinded, Placebo-Controlled Trial
Anabolic steroids have been used to treat lower extremity ulcerations, including venous and cryofibrinogenemic ulcers and lipodermatosclerosis (LDS). Yet there have been no studies to determine the severity and reversibility of side effects of anabolic steroids on liver enzymes and lipid profiles in elderly patients. We therefore evaluated, in a prospective, randomized, double-blinded, placebo-controlled trial, the extent and reversibility of abnormal liver enzymes and lipid profiles in patients with LDS and venous leg ulcers treated with stanozolol at 2 mg twice daily for up to 6 months. Follow-up laboratory testing was d...
Source: The International Journal of Lower Extremity Wounds - April 8, 2015 Category: Surgery Authors: Carson, P., Hong, C. J., Otero-Vinas, M., Arsenault, E. F., Falanga, V. Tags: Clinical and Translational Research Source Type: research

Safety and Effectiveness of Therapeutic Magnetic Resonance in the Management of Postsurgical Lesion of the Diabetic Foot
To evaluate the safety and effectiveness of therapeutic magnetic resonance (TMR) in the management of the diabetic foot (DF), we treated a group of consecutive type 2 diabetic inpatients with wide postsurgical lesions (Group A: N = 10; age 67.7 ± 18.9 years, duration of diabetes 22.3 ± 6.6 years, 8.1 ± 1.1%, body mass index 29.4 ± 2.1 kg/m2), for 2 consecutive weeks, while admitted, with a low-intensity magnetic resonance equipment, in addition to standard treatment. Patients, compared with a matched control group with the same clinical characteristics (Group B), were then followed monthly for 6...
Source: The International Journal of Lower Extremity Wounds - April 8, 2015 Category: Surgery Authors: Abbruzzese, L., Iacopi, E., Coppelli, A., Bonino, G., Goretti, C., Piaggesi, A. Tags: Clinical and Translational Research Source Type: research