Hypoxia Regulates the Therapeutic Potential of Mesenchymal Stem Cells Through Enhanced Autophagy

In conclusion, hypoxia pretreatment enhances survival in BM-MSCs, promoting angiogenesis by increasing autophagy and significantly decreasing apoptosis. Therefore, modulation of autophagy with hypoxic pretreatment may provide a novel strategy to improve MSC-based therapies.

Source: The International Journal of Lower Extremity Wounds - April 8, 2015 Category: Surgery Authors: Liu, J., Hao, H., Huang, H., Tong, C., Ti, D., Dong, L., Chen, D., Zhao, Y., Liu, H., Han, W., Fu, X. Tags: Basic and Experimental Research Source Type: research