The International Journal of Lower Extremity Wounds This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Deep Vein Thrombosis After Total Hip Arthroplasty and Total Knee Arthroplasty in Patients With Previous Ischemic Stroke
The present study evaluated the prevalence and therapy of deep vein thrombosis (DVT) after total hip arthroplasty (THA) and total knee arthroplasty (TKA) in 57 patients with previous ischemic stroke. Postoperative anticoagulants were used for DVT prophylaxis, and batroxobin and prolonged anticoagulants were used for thrombolysis in DVT subjects. The incidence of DVT after THA and TKA in patients with previous ischemic stroke was 16.2% and 20%, respectively. No bleeding complications were observed and no new ischemic stroke occurred during the following 3 months. The prevalence DVT after THA and TKA in patients with previou...
Source: The International Journal of Lower Extremity Wounds - December 17, 2013 Category: Surgery Authors: Qin, J., Xu, Z., Shi, D., Chen, D., Dai, J., Teng, H., Jiang, Q. Tags: Clinical Research Source Type: research

Association of Variant rs7903146 (C/T) Single Nucleotide Polymorphism of TCF7L2 Gene With Impairment in Wound Healing Among North Indian Type 2 Diabetes Population: A Case-Control Study
The variants of transcription factor 7-like 2 (TCF7L2) gene have been shown to be associated with type 2 diabetes mellitus (T2DM) and its several secondary complications. Here, we aimed to examine the possible role of one of the common variant of this gene, rs7903146 (C/T), with impairment of wound healing in cases with T2DM. A total of 750 individuals, including 322 patients with T2DM and 120 patients with diabetic foot ulcers (DFUs) and 308 controls, were analyzed for rs7903146 variant of the TCF7L2 gene. Genotyping was done by polymerase chain reaction–restriction fragment length polymorphism. For rs7903146 varian...
Source: The International Journal of Lower Extremity Wounds - December 17, 2013 Category: Surgery Authors: Singh, K., Agrawal, N. K., Gupta, S. K., Singh, K. Tags: Clinical Research Source Type: research

Unilateral Livedoid Vasculopathy Associated With Involutional Phase of Cutaneous Infantile Hemangioma: The Connection to Coagulation Disorders
We present a young boy with an association between livedoid vasculopathy in the area of a previous involuted cutaneous hemangioma. We found 4 uncommon abnormalities associated with thrombo-occlusive events: heterozygous 20210 A->G genotype of prothrombin, reduced activity of anticoagulation proteins C and S, and elevated lipoprotein (a). (Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - December 17, 2013 Category: Surgery Authors: Criado, P. R., Alavi, A., Halpern, I., Sotto, M. N., Kirsner, R. S. Tags: Case Reports Source Type: research

Septic Nonunions of Lower Limb Long Bones: Don't Neglect Propionibacterium acnes!
We report 3 clinical cases of septic nonunions of lower limb long bones in which the pathogenicity of Propionibacterium acnes was retained after several weeks of poor outcome. The patients had fractures that were treated by internal fixation, without initially suspected infection. The diagnosis of delayed union coincided with the onset of treatment. Support was performed in 2 steps, allowing for the collection of several deep samples that were referred for microbiological analysis. Molecular techniques for microbiological investigation were performed on perioperative samples and were not contributive. The detection of P ac...
Source: The International Journal of Lower Extremity Wounds - December 17, 2013 Category: Surgery Authors: Gaillard, C., Dupond, M., Brisou, P., Gaillard, T. Tags: Case Reports Source Type: research

Squamous Cell Carcinoma and Ledderhose Disease: A Case Report
Ledderhose disease is disorder of the plantar aponeurosis. This disease is not so common and can be tackled with a surgical or conservative approach. A case of a 73-year-old man came to our attention who had a 26-year history of painless bilateral plantar nodules coalescing into an indurated mass. An ulcerative nodule had been noted in the last 16 months on the right foot, in the absence of trauma, not responsive to conservative treatment, so we decided to perform a biopsy. The histopatologic examination showed squamous cell carcinoma, with warty, well-differentiated, low-grade malignancy. Surgical treatment was suggested,...
Source: The International Journal of Lower Extremity Wounds - December 17, 2013 Category: Surgery Authors: Motolese, A., Mola, F., Cherubino, M., Giaccone, M., Pellegatta, I., Valdatta, L. Tags: Case Reports Source Type: research

A Case of Fatal Necrotizing Fasciitis Arising From Chronic Lymphedema
Chronic lymphedema and lymphangitis are common adverse effects following treatment for gynecological cancer. Because the early symptoms of necrotizing fasciitis are similar to those of lymphangitis, fatal outcome can occur if patients or physicians underestimate this condition. Here, we present a case of necrotizing fasciitis in a patient with chronic lymphedema. (Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - December 17, 2013 Category: Surgery Authors: Jun, Y. J., Kang, I. S., Lee, J. H., Kim, S. M., Kim, Y. J. Tags: Case Reports Source Type: research

The Importance of Wound Biopsy in the Accurate Diagnosis of Acral Malignant Melanoma Presenting as a Foot Ulcer
We report a case of rapidly progressing plantar melanoma presenting as a chronic, nonhealing ulcer. A 46-year-old patient presented at a specialized Wound Healing Center with an enlarging painful ulcer on the right heel of 3 months duration. The wound was biopsied and specimens were sent for examination at the Wound Pathology service at the Department of Dermatology and Cutaneous Surgery, University of Miami. Histology demonstrated features consistent with acral malignant melanoma. Immunohistochemistry using melanocytic markers MART-1, S-100, HMB-45 revealed positive staining indicating the presence of malignant cells, and...
Source: The International Journal of Lower Extremity Wounds - December 17, 2013 Category: Surgery Authors: Yin, N. C., Miteva, M., Covington, D. S., Romanelli, P., Stojadinovic, O. Tags: Case Reports Source Type: research

White Grain Mycetoma Caused by Scedosporium apiospermum in North India: A Case Report
We report a case of mycetoma caused by Scedosporium apiospermum in the right foot of a 45-year-old farmer in north India. The patient had a history of trauma in the sole of the right foot followed by discharge of white granules along with proximal progression. Scedosporium apiospermum was identified based on colony characteristics and microscopic features on slide culture. Mycetoma is a progressive disease. Foot is commonly affected in persons who walk barefoot, especially in south India. Untreated mycetoma progress and involve the underlying fasciae and tissues along with bones often resulting in loss of limb. By prompt a...
Source: The International Journal of Lower Extremity Wounds - December 17, 2013 Category: Surgery Authors: Gupta, M. K., Banerjee, T., Kumar, D., Rastogi, A., Tilak, R. Tags: Case Reports Source Type: research

A Minimally Invasive Modified Reverse Sural Adipofascial Flap for Treating Posttraumatic Distal Tibial and Calcaneal Osteomyelitis
Our aim was to report a modified reverse sural adipofascial flap for treating posttraumatic distal tibial or calcaneal osteomyelitis. We retrospectively reviewed the records of 15 patients with posttraumatic distal tibial or calcaneal osteomyelitis treated with modified reverse sural adipofascial flaps between 2005 and 2010. The flap was raised through 2 short incisions in the posterior aspect of the lower leg. The raw surface of the flap was covered with a full-thickness skin graft. Donor sites were closed primarily. Lower Extremity Functional Scale (LEFS) scores and 2-point discrimination (TPD) were recorded preoperative...
Source: The International Journal of Lower Extremity Wounds - December 17, 2013 Category: Surgery Authors: Yang, C., Geng, S., Fu, C., Sun, J., Bi, Z. Tags: Case Reports Source Type: research

Citric Acid Treatment of Chronic Nonhealing Ulcerated Tophaceous Gout With Bursitis
We report chronic nonhealing tophaceous gout with bursitis in an 80-year-old male, not responding to conventional treatment modality for months together. This nonhealing ulcer was treated successfully with local application of 3% citric acid ointment for 22 days. (Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - December 17, 2013 Category: Surgery Authors: Nagoba, B. S., Punpale, A., Poddar, A., Suryawanshi, N. M., Swami, G. A., Selkar, S. P. Tags: Case Reports Source Type: research

Ascending Infection of Foot Tendons in Diabetic Patients
We describe four cases of diabetic foot infection complicated by long ascending infection. All did not respond initially to antibiotic treatment and the usual surgical debridement and were cured only after excision of the infected tendons. We highlight a rare but serious complication of the diabetic foot disease not commonly seen by the surgical community. We hope that this report raises the awareness of this condition so that a prompt diagnosis is made and appropriate treatment started, thereby reducing the risk of major lower limb amputations. (Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - December 17, 2013 Category: Surgery Authors: Mismar, A., Yousef, M., Badran, D., Younes, N. Tags: Case Reports Source Type: research

Effect of Radiofrequency Ablation on Healing of Infected Full-Thickness Wounds in Minipigs
The success of debridement is critical to optimize the treatment outcomes of traumatic wounds. To investigate the impact of radiofrequency ablation on healing potential of infected wounds, minipigs with infected full-thickness skin defects on backs were divided into 4 treatment groups randomly: radiofrequency ablation debridement, electric knife debridement, sharp instrument debridement, and no treatment. The healing rate, healing time, tissue filling rate, bacterial quantitative, and histological assay were evaluated postoperatively. The results obtained provide evidence that the wounds after radiofrequency ablation treat...
Source: The International Journal of Lower Extremity Wounds - December 17, 2013 Category: Surgery Authors: Yang, R., Zuo, T., Zhu, J., Zhong, H., Wu, K., Hou, S. Tags: Clinical and Experimental Research Source Type: research

Bone Marrow Cell Mobilization by the Systemic Use of Granulocyte Colony-Stimulating Factor (GCSF) Improves Wound Bed Preparation
In this report, we show that systemic injections of granulocyte colony-stimulating factor (GCSF) can mobilize stem cells from bone marrow into the peripheral blood and then to the wound site. Our objectives were to optimize parameters for this method by using mouse models and proof of principle in a human chronic wound situation. Mice were injected for 5 days with 2 different formulations of GCSF and compared to control saline. To monitor stem cell mobilization, flow cytometric measurements of Sca-1 and c-Kit and colony-forming cell assays were performed. Full-thickness tail wounds in mice were created and monitored for he...
Source: The International Journal of Lower Extremity Wounds - December 17, 2013 Category: Surgery Authors: Iwamoto, S., Lin, X., Ramirez, R., Carson, P., Fiore, D., Goodrich, J., Yufit, T., Falanga, V. Tags: Clinical and Experimental Research Source Type: research

Factors Associated With Calcification in the Pedal Arteries in Patients With Diabetes and Neuropathy Admitted for Foot Disease and Its Clinical Significance
In conclusion, the predictive variables related to the presence of CPAs in a series of patients admitted for foot disease were duration of diabetes >20 years, retinopathy, albuminuria, and peripheral arterial disease. Differences in the outcomes were related to the association of CPAs with peripheral arterial disease. (Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - December 17, 2013 Category: Surgery Authors: Aragon-Sanchez, J., Lazaro-Martinez, J. L. Tags: Translational Research Source Type: research

Editorial
(Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - December 17, 2013 Category: Surgery Authors: Mani, R. Tags: Editorial Source Type: research