The International Journal of Lower Extremity Wounds This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Vasculitic Ulcers
Vasculitic ulcers are an emerging problem in wound care that needs to be well defined and adequately approached by caregivers. Cutaneous vasculitis includes several inflammatory disorders that compromise microvessels and specifically the cutaneous vascular system: arterioles, capillaries, postcapillary venules. The pathogenetic role of circulating immunocomplexes and autoantibodies (antineutrophil antibodies) in these diseases has been widely demonstrated in animal models and in humans. Vasculitis can be limited to the skin or represent the cutaneous signs in case of systemic vasculitis with visceral involvement. The injur...
Source: The International Journal of Lower Extremity Wounds - March 1, 2016 Category: Surgery Authors: Papi, M., Papi, C. Tags: Original Review Source Type: research

Is There a Need for Change in Managing Mixed Arteriovenous Leg Ulcers?
(Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - March 1, 2016 Category: Surgery Authors: Rerkasem, K., Mani, R. Tags: Editorial Source Type: research

Chronic Ulceration and Sinus Formation due to Foreign Body: An Often-Forgotten Problem
We present a more than 9 years long medical record of a 49 year old man after a simple surgical procedure. The background was a sinus formation generated from a foreign body reaction. The case report shows that this condition is often overlooked and even using advanced equipment, it is difficult to diagnose. The only solution is to diagnose and remove the triggering cause. Fistulography and ultrasound scanning seem to be the optimal diagnostic tool in these cases. The knowledge of the foreign body reaction in tissue continuously needs to be reestablished in the health care system especially in areas, where implantation of ...
Source: The International Journal of Lower Extremity Wounds - December 17, 2015 Category: Surgery Authors: Hansen, K. B., Gottrup, F. Tags: Case Series and Case Report Source Type: research

Modern Orthopedic Inpatient Care of the Orthopedic Patient With Diabetic Foot Disease
In this article, we describe emergency and elective pathways within our orthopedic multidisciplinary inpatient care of patients with diabetic foot problems. We performed a retrospective cohort review of 19 complex patients requiring orthopedic surgical treatment of infected ulceration or Charcot feet or deformity at our institution. A total of 30 admissions (19 emergency, 11 elective) were included. The pathways were coordinated by a multidisciplinary team and comprised initial assessment and investigation and a series of key events, which consisted of emergency and elective surgery together with the introduction, and chan...
Source: The International Journal of Lower Extremity Wounds - December 17, 2015 Category: Surgery Authors: Bateman, A. H., Bradford, S., Hester, T. W., Kubelka, I., Tremlett, J., Morris, V., Pendry, E., Kavarthapu, V., Edmonds, M. E. Tags: Clinical and Translational Research Source Type: research

Risk Factors for Chronic Intertrigo of the Lymphedema Leg in Southern India: A Case-Control Study
Rich clinical experiences indicate that toe web intertrigo is a major predisposing condition for cellulitis/acute dermatolymphango adenitis (ADLA) and the number of lesions is the strongest predictor of frequency of ADLA in lymphedema (LE) patients. However, there is scanty information on the risk factors for the establishment of chronic toe web intertrigo in LE patients. We performed a case-control study recruiting 52 lower limb LE with intertrigo and 52 lower limb LE without intertrigo in community settings and assessed general and local potential risk factors for chronic intertrigo. Analysis of local risk factors reveal...
Source: The International Journal of Lower Extremity Wounds - December 17, 2015 Category: Surgery Authors: De Britto, L. J., Yuvaraj, J., Kamaraj, P., Poopathy, S., Vijayalakshmi, G. Tags: Clinical and Translational Research Source Type: research

What Is the Clinical Utility of the Ankle-Brachial Index in Patients With Diabetic Foot Ulcers and Radiographic Arterial Calcification?
The purpose of this study was to analyze the influence of radiographic arterial calcification (RAC) on the clinical interpretation of ankle-brachial index (ABI) values in patients with diabetic foot ulcers. We analyzed a retrospective clinical database of 60 patients with diabetic foot ulcers from the Diabetic Foot Unit (Complutense University, Madrid, Spain) between January 2012 and March 2014. For each patient, anteroposterior XR-plains were evaluated, and the ABI and toe-brachial index (TBI) were assessed by an experienced clinician. To analyze the correlation among quantitative variables, we applied the Pearson correla...
Source: The International Journal of Lower Extremity Wounds - December 17, 2015 Category: Surgery Authors: Alvaro-Afonso, F. J., Lazaro-Martinez, J. L., Aragon-Sanchez, J., Garcia-Morales, E., Garcia-Alvarez, Y., Molines-Barroso, R. J. Tags: Clinical and Translational Research Source Type: research

Cytokeratin Expression at Different Stages in Sweat Gland Development of C57BL/6J Mice
Sweat glands exhibit a documented role in epidermal reepithelialization after wounding. However, the regenerative potential of sweat glands has remained underappreciated due to the absence of useful markers for the analysis of determination and differentiation processes in the developing eccrine sweat gland from epithelium. Although the current knowledge of keratin expression in most of the different origins has been described, it remains widely shared and not unified in eccrine sweat glands of C57BL/6J mice that are commonly used as animal models for sweat gland and wound healing studies, both at the molecular and cellula...
Source: The International Journal of Lower Extremity Wounds - December 17, 2015 Category: Surgery Authors: Xie, J., Yao, B., Han, Y., Shang, T., Gao, D., Yang, S., Ma, K., Huang, S., Fu, X. Tags: Basic and Experimental Research Source Type: research

Topical Application of Insulin Accelerates Vessel Maturation of Wounds by Regulating Angiopoietin-1 in Diabetic Mice
Reestablishment of the structural and functional microvasculature would be beneficial to promote healing of diabetic wounds. We explored the role of insulin application on microvascular maturation of diabetic wounds to determine whether it is associated with insulin-induced wound healing. We adopted the multiple injections of streptozotocin (STZ) to establish a diabetic animal model. The effect of insulin on microvessel formation, especially the effect of insulin on microvascular maturation was observed by transmission electron microscopy and laser scanning confocal microscopy. The pivotal protein regulated by insulin duri...
Source: The International Journal of Lower Extremity Wounds - December 17, 2015 Category: Surgery Authors: Li, C., Yu, T., Liu, Y., Chen, X., Zhang, X. Tags: Basic and Experimental Research Source Type: research

Opuntia Extract Reduces Scar Formation in Rabbit Ear Model: A Randomized Controlled Study
In conclusion, opuntia extract reduces hypertrophic scar formation by means of type I collagen inhibition, and increasing type III collagen and MMP-1.T he novel application of opuntia extract may lead to innovative and effective antiscarring therapies. (Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - December 17, 2015 Category: Surgery Authors: Fang, Q., Huang, C., You, C., Ma, S. Tags: Basic and Experimental Research Source Type: research

Effects of the Four-Herb Compound ANBP on Wound Healing Promotion in Diabetic Mice
In this study, we first used the ultralow temperature preparation method to produce mixed superfine powder from Agrimonia pilosa (A), Nelumbo nucifera (N), Boswellia carteri (B), and Pollen typhae (P), named as ANBP. Applying ANBP on 40 streptozotocin (STZ)-induced diabetic C57BL/6 mice (4-6 weeks, 20 ± 2 g), we observed that the wound healing process was accelerated and the wound healing time was shortened (14 days, P < .05). Pathological observation using hematoxylin–eosin staining indicated that inflammatory cells were reduced (P < .05) while the thickness of granulation tissue and length of epithelia...
Source: The International Journal of Lower Extremity Wounds - December 17, 2015 Category: Surgery Authors: Hou, Q., He, W.-J., Chen, L., Hao, H.-J., Liu, J.-J., Dong, L., Tong, C., Li, M.-R., Zhou, Z.-Z., Han, W.-D., Fu, X.-B. Tags: Basic and Experimental Research Source Type: research

Management of Necrotizing Fasciitis and Its Surgical Aspects
Necrotizing fasciitis (NF) is a severe and rapidly progressive infectious disease that attacks superficial an as well as deep fascia, subcutaneous fat tissue, and muscle. Although the incidence is of relatively low frequency, the median mortality is high. NF is a great burden to patients and hospitals. The most common cause of NF is trauma injuries, followed by other conditions with comorbidity. A classification for NF was presented concerning microbial cause, depth of infection, and anatomy. But the value of classification is not convincing. Early diagnosis of NF is essential and still to be realized by far. Information f...
Source: The International Journal of Lower Extremity Wounds - December 17, 2015 Category: Surgery Authors: Sun, X., Xie, T. Tags: Reviews Source Type: research

Necrotizing Fasciitis and The Diabetic Foot
Necrotizing fasciitis (NF) represents a rapidly progressive, life-threatening infection involving skin, soft tissue, and deep fascia. An early diagnosis is crucial to treat NF effectively. The disease is generally due to an external trauma that occurs in predisposed patients: the most important risk factor is represented by diabetes mellitus. NF is classified into 3 different subtypes according to bacterial strains responsible: type 1 associated to polymicrobial infection, type 2 NF, generally associated to Streptococcus species, often associated to Staphylococcus aureus and, eventually, Type 3, due to Gram-negative strain...
Source: The International Journal of Lower Extremity Wounds - December 17, 2015 Category: Surgery Authors: Iacopi, E., Coppelli, A., Goretti, C., Piaggesi, A. Tags: Reviews Source Type: research

Translating Innovations to Success
(Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - December 17, 2015 Category: Surgery Authors: Rerkasem, K., Mani, R. Tags: Editorial Source Type: research

Response to Letter From Benjamin A. Lipsky
(Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - October 9, 2015 Category: Surgery Authors: Wang, P. Tags: Letter to Editor Source Type: research

Stopping Antibiotic Therapy for a Diabetic Foot Infection: Some Answers, but More Questions
(Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - October 9, 2015 Category: Surgery Authors: Lipsky, B. A. Tags: Letter to Editor Source Type: research