The International Journal of Lower Extremity Wounds This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Managing Diabetic Foot Infection in India
The burden of diabetic foot complications, in terms of both physical and socioeconomical constraints, poses a heavy challenge both to the patient and the physician, especially in developing countries, where the number of people living with diabetes is increasing at an alarming rate compared with the developed world. In developing countries like India, there are specific causes and risk factors that increase the burden of diabetic foot infections (DFIs), for example, sociocultural risk factors such as barefoot walking, using improper footwear, poor knowledge of foot care practices, lack of adequate and timely access to podi...
Source: The International Journal of Lower Extremity Wounds - June 14, 2013 Category: Surgery Authors: Viswanathan, V., Rao, V. N. Tags: Review Source Type: research

Hyperbaric Oxygen Therapy as Adjunctive Treatment for Diabetic Foot Ulcers
Hyperbaric oxygen therapy (HBOT) has been suggested to improve healing of hard-to-heal diabetic foot ulcers. Although the wide use of HBOT as a treatment for diabetic foot ulcers has been founded on weak scientific ground, 2 well-designed randomized, double-blind, placebo-controlled studies have in recent years put HBOT on firmer ground as treatment for diabetic patients with chronic foot ulcers. The recognition of inclusion criteria in these studies may help identify a select group of diabetic patients with hard-to-heal ulcers who might benefit from HBOT. In this review, we discuss the rationale behind the use of HBOT, it...
Source: The International Journal of Lower Extremity Wounds - June 14, 2013 Category: Surgery Authors: Londahl, M. Tags: Review Source Type: research

Revision Surgery for Diabetic Foot Infections: Giving Another Chance to the Patient
Revision surgery (RS) is frequently needed to control diabetic foot infections. It is the aim of this retrospective observational study to analyze the variables associated with undergoing RS and the variables associated with undergoing a major amputation when RS was required. We conducted a retrospective study of patients with diabetes treated in our department during 10 years (January 1, 2000 to January 1, 2010) who had foot infections identifying those who required RS. In all, 167 out of 417 patients (40%) with diabetes who underwent surgery for foot infections underwent RS for persistent infection. The predictive variab...
Source: The International Journal of Lower Extremity Wounds - June 14, 2013 Category: Surgery Authors: Aragon-Sanchez, J., Lazaro-Martinez, J. L., Molines-Barroso, R., Garcia Alvarez, Y., Quintana-Marrero, Y., Hernandez-Herrero, M. J. Tags: Seminar Review Source Type: research

Current Achievements With Topical Negative Pressure to Improve Wound Healing in Dehiscent Ischemic Stumps of Diabetic Patients: A Case Series
Negative pressure wound therapy has been increasingly used either as a primary or as an adjunctive therapeutic measure to treat a variety of recalcitrant wounds during the past years. It is thought to act by creating a local environment that promotes cell proliferation, angiogenesis, and granulation tissue formation, leading to accelerated wound healing to the point of spontaneous closure or reducing the wound size to facilitate significantly further surgical reconstruction. This case series presents our preliminary experience with the use of a Topical Negative Pressure system in the treatment of challenging ischemic wound...
Source: The International Journal of Lower Extremity Wounds - June 14, 2013 Category: Surgery Authors: Georgakarakos, E., Charalampidis, D., Kakagia, D., Georgiadis, G. S., Lazarides, M. K., Papanas, N. Tags: Case Reports Source Type: research

Super-Oxidized Solution (Dermacyn Wound Care) as Adjuvant Treatment in the Postoperative Management of Complicated Diabetic Foot Osteomyelitis: Preliminary Experience in a Specialized Department
Surgery is usually used to treat diabetic foot osteomyelitis (DFO), whether primarily or in cases in which antibiotics are not able to control infection. In many cases, the bone is only partially removed, which means that residual infection remains in the bone margins, and the wound is left open to heal by secondary intent. The use of culture-guided postoperative antibiotic treatment and adequate management of the wound must be addressed. No trials exist dealing with local treatment in the postoperative management of these cases of complicated DFO. We decided to test a super-oxidized solution, Dermacyn Wound Care (DWC; Ocu...
Source: The International Journal of Lower Extremity Wounds - June 14, 2013 Category: Surgery Authors: Aragon-Sanchez, J., Lazaro-Martinez, J. L., Quintana-Marrero, Y., Sanz-Corbalan, I., Hernandez-Herrero, M. J., Cabrera-Galvan, J. J. Tags: Case Reports Source Type: research

Wound Fluid in Diabetic Foot Ulceration: More Than Just an Undefined Soup?
Valid and reproducible sampling techniques as well as processing protocols are required for the assessment of biomarkers and mediators contained in wound exudate. Moreover, the ideal technique should be easy to use even in daily clinical routine. This is challenging since wound fluid represents an inhomogeneous mixture of different exogenous and endogenous sources. Analyzing wound fluid, however, may facilitate clinical decision making. Many techniques for obtaining wound fluid have been described. There is very little validation data, and the array of different techniques appears confusing. Structuring and new standards a...
Source: The International Journal of Lower Extremity Wounds - June 14, 2013 Category: Surgery Authors: Loffler, M. W., Schuster, H., Buhler, S., Beckert, S. Tags: Review Source Type: research

Risk Factors and Gene Type for Infections of MRSA in Diabetic Foot Patients in Tianjin, China
The objective was to study risk factors and gene type of DF patients infected with MRSA. A total of 429 DF patients were recruited. The patients with S aureus infections were divided into MRSA and MSSA groups. MRSA were genotyped by SCCmec. pvl and lukE-lukD were detected. A total of 559 pathogens were isolated from them, with G+ bacteria firstly(59.0%), followed G- bacilli (37.7%) and true fungi (3.3%). The 3 most frequently isolated pathogens were S aureus (35.2%), S epidermidis (12.3%), and Pseudomonas aeruginosa (11.2%). SCCmec III MRSA and SCCmec IVa MRSA had the same antibacterial spectrum. mecA positive rate was 100...
Source: The International Journal of Lower Extremity Wounds - June 14, 2013 Category: Surgery Authors: Feng, S.-H., Chu, Y.-J., Wang, P.-H., Jun, X., Min, D., Li, X.-M. Tags: Clinical Research Source Type: research

Effect of Daptomycin on Local Interleukin-6, Matrix Metalloproteinase-9, and Metallopeptidase Inhibitor 1 in Patients With MRSA-Infected Diabetic Foot
Infection is a major cause of the diabetic foot syndrome being aggravating by the increased burden of multiresistant germs like methicillin-resistant Staphylococcus aureus (MRSA). Maximizing positive outcome for serious MRSA infections requires an aggressive treatment approach and a careful monitoring of the healing process. Therefore, we examined 8 patients with MRSA-infected diabetic foot syndrome Wagner classification grades 2 or 3 (corresponding to the Texas classification stage 2 and 3) during antibiotic treatment with daptomycin. We documented the wound size and obtained samples of wound secretion for analyses of pro...
Source: The International Journal of Lower Extremity Wounds - June 14, 2013 Category: Surgery Authors: Ambrosch, A., Halevy, D., Fwity, B., Brin, T., Lobmann, R. Tags: Clinical Research Source Type: research

The Performance of Serum Inflammatory Markers for the Diagnosis and Follow-up of Patients With Osteomyelitis
Serum inflammatory markers, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), white blood cells (WBC), and procalcitonin (PCT), have been used for the diagnosis of foot infections in patients with diabetes. However, little is known about their changes during treatment of patients with foot infections. The aim of this prospective study was to examine the performance of serum inflammatory markers for the diagnosis and follow-up of patients with osteomyelitis. A total of 61 patients (age 63.1 ± 7.0 years, 45 men and 16 women, 7 with type 1 and 54 with type 2 diabetes) with untreated foot infection (34 wit...
Source: The International Journal of Lower Extremity Wounds - June 14, 2013 Category: Surgery Authors: Michail, M., Jude, E., Liaskos, C., Karamagiolis, S., Makrilakis, K., Dimitroulis, D., Michail, O., Tentolouris, N. Tags: Clinical Research Source Type: research

Tissue and Swab Culture in Diabetic Foot Infections: Neuropathic Versus Neuroischemic Ulcers
In conclusion, swab cultures are highly sensitive but less specific and have an excellent NPV both in diabetic patients with neuropathic and in those with neuroischemic foot ulcer. There are no differences between the groups in microbial load. (Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - June 14, 2013 Category: Surgery Authors: Demetriou, M., Papanas, N., Panopoulou, M., Papatheodorou, K., Bounovas, A., Maltezos, E. Tags: Clinical Research Source Type: research

Advances in Infections and Wound Healing for the Diabetic Foot: The Die Is Cast
(Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - June 14, 2013 Category: Surgery Authors: Papanas, N., Mani, R. Tags: Editorial Source Type: research

Update on the Diabetic Foot 2012: The 14th Biennial Malvern Diabetic Foot Conference, May 9-11, 2012
The 14th biennial Malvern Diabetic Foot Conference was held in May 2012. Physicians, podiatrists, nurses, orthotists, surgeons, radiologists, and other professionals attended to reflect on the diabetic foot. The conference comprised interactive workshops, oral presentations of new research findings, and lectures from leading figures in the world of the diabetic foot. Over the 3 days, topics such as epidemiology, neuropathy, screening, vascular disease, prevention, and management among others were discussed. The conference has been an excellent platform from which to share new and ongoing research and it will without a doub...
Source: The International Journal of Lower Extremity Wounds - March 15, 2013 Category: Surgery Authors: Lamont, P., Franklyn, K., Rayman, G., Boulton, A. J. M. Tags: Regular Features Source Type: research

Leg Ulcers Associated With Giant Cell Arteritis Relapse
(Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - March 15, 2013 Category: Surgery Authors: Misciali, C., Tengattini, V., Baraldi, C., Magnani, L., Patrizi, A. Tags: Letter to the Editor Source Type: research

Gram-Negative Diabetic Foot Osteomyelitis: Risk Factors and Clinical Presentation
In conclusion, gram-negative organisms were isolated in nearly half of our cases of DFO and were associated with more severe infections, higher white blood cell counts, lower glycated hemoglobin levels, and wounds of traumatic etiology. (Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - March 15, 2013 Category: Surgery Authors: Aragon-Sanchez, J., Lipsky, B. A., Lazaro-Martinez, J. L. Tags: Case Report Source Type: research

The Application of Distally Pedicled Peroneus Brevis Muscle Flaps and Retrograde Neurocutaneous Accompanying Artery Flaps for Treatment of Bony and Soft-Tissue 3-Dimensional Defects of the Lower Leg and Foot
In conclusion, distally pedicled peroneus brevis muscle flaps and retrograde neurocutaneous flaps are simple, safe, reliable, and suitable for clinical treatment of hole-shaped bony defects and reconstruction of soft-tissue defects within a single stage, especially when the 2 defects are located in different 3-dimensional spaces. (Source: The International Journal of Lower Extremity Wounds)
Source: The International Journal of Lower Extremity Wounds - March 15, 2013 Category: Surgery Authors: Hu, X.-h., Du, W.-l., Chen, Z., Li, M., Wang, C., Shen, Y.-m. Tags: Case Report Source Type: research