A CD30(-) Transformed Mycosis Fungoides Case Responding Very Well to Systemic Bexarotene and Methotrexate

The course of mycosis fungoides (MF) is indolent except when transformation to a large T-cell lymphoma occurs. The diagnosis of transformed MF relies on the presence of more than 25% of large cells on biopsy of an MF lesion. Treatment of transformed MF is a major challenge as these patients have poor outcome. Here, we report a 61-year-old man presenting with tumoral ulcer on the plantar area of the foot who was diagnosed cutaneous CD30(–) large cell transformed MF and treated with systemic methotraxate and bexarotene therapy.

Source: The International Journal of Lower Extremity Wounds - June 13, 2014 Category: Surgery Authors: Zindanci, I., Kavala, M., Turkoğlu, Z., Can, B., Ozturk, E., Zemheri, E., Akbulak, O., Mansuroglu, C., Topaloğlu Demir, F. Tags: Case Report Source Type: research