Rituximab for the therapy of systemic sclerosis: a series of 10 cases in a single center
This study was conducted with the aim to retrospectively evaluate all patients who used RTX for the treatment of SSc in our center. Patients and methods We retrospectively evaluated medical records of all patients with SSc who used RTX to treat this disease from January 2009 to January 2015. Systemic, cutaneous, and pulmonary involvement data and laboratory results before and six months after the first infusion of RTX were collected. Results Ten patients received treatment during the study period and were included in this series. All patients had a diffuse form of the disease. Five patients suffered from an early (durati...
Source: Revista Brasileira de Reumatologia - October 25, 2016 Category: Rheumatology Source Type: research
IL33 in rheumatoid arthritis: potential contribution to pathogenesis
ABSTRACT A better understanding of the inflammatory mechanisms of rheumatoid arthritis and the development of biological therapy revolutionized its treatment, enabling an interference in the synovitis – structural damage – functional disability cycle. Interleukin 33 was recently described as a new member of the interleukin-1 family, whose common feature is its pro-inflammatory activity. Its involvement in the pathogenesis of a variety of diseases, including autoimmune diseases, raises the interest in the possible relationship with rheumatoid arthritis. Its action has been evaluated in experimental models of arthritis...
Source: Revista Brasileira de Reumatologia - October 25, 2016 Category: Rheumatology Source Type: research
What rheumatologists should know about orofacial manifestations of autoimmune rheumatic diseases
This article reviews the main orofaci al manifestations of rheumatic diseases that may be of interest to the rheumatologist for diagnosis and monitoring of autoimmune rheumatic diseases.RESUMO Manifesta ções orofaciais ocorrem com frequência nas doenças reumáticas e, comumente, representam sinais iniciais ou de atividade da doença que ainda são negligenciados na prática clínica. Entre as doenças reumáticas autoimunes com possíveis manifestações orais, incluem-se a artrite reumatoide ( AR), miopatias inflamatórias (MI), esclerose sistêmica (ES), lúpus eritematoso sistêmico (LES), policondrite recidivante (...
Source: Revista Brasileira de Reumatologia - October 25, 2016 Category: Rheumatology Source Type: research
Clinical characteristics and frequency of TLR4 polymorphisms in Brazilian patients with ankylosing spondylitis
Conclusions: TLR4 polymorphisms 399 and 299 were not more frequent in patients with AS in comparison to the health controls and none of the clinical variables were associated with these polymorphisms.RESUMO Objetivos: A imunidade inata est á envolvida na fisiopatologia da espondilite anquilosante (EA), com a participação de bactérias gram-negativas, modulação do antígeno leucocitário humano (HLA) B27 e o envolvimento de receptores de reconhecimento de padrões, como os receptores Toll-like (TLR). O objetivo deste estudo foi in vestigar as características clínicas e a frequência de polimorfismos em TLR4 (Asp299G...
Source: Revista Brasileira de Reumatologia - October 25, 2016 Category: Rheumatology Source Type: research
A new musculoskeletal ultrasound scoring system (US10) of the hands and wrist joints for evaluation of early rheumatoid arthritis patients
Conclusion: The proposed US10 scoring system proved to be a useful tool for monitoring inflammation and joint damage in early RA patients, demonstrating significant correlations with longitudinal changes in disease activity and functional status.RESUMO Objetivo: Propor um novo sistema de escore ultrassonogr áfico das articulações da mão e punho (US10) para a avaliação de pacientes com artrite reumatoide (AR) e correlacionar o US10 com variáveis clínicas, laboratoriais e funcionais. Métodos: Foram submetidos 48 pacientes com AR em fase inicial a avaliações clínicas e laboratoriais, bem como a exames cegos de ...
Source: Revista Brasileira de Reumatologia - October 25, 2016 Category: Rheumatology Source Type: research
Methylene tetrahydrofolate reductase, transforming growth factor-β1 and lymphotoxin-α genes polymorphisms and susceptibility to rheumatoid arthritis
Conclusion: Our findings suggest that there is association between MTHFR C677 T and LT- α A252G genes polymorphisms and increased risk of RA in this sample of Egyptian population.RESUMO Antecedentes: A artrite reumatoide é uma doença autoimune amplamente prevalente com sugerida predisposição genética. Objetivos: Detectar o padrão de polimorfismo dos genes metilenotetrahidrofolato redutase (MTHFR C677 T e A1298 C), fator de crescimento transformador β 1 (TGF- β 1 T869 C) e linfotoxina- α (LT- α A252G) em pacientes com artrite reumatoide e correlacionar esses padr ões com a atividade da doença e os níveis ...
Source: Revista Brasileira de Reumatologia - October 25, 2016 Category: Rheumatology Source Type: research
Sensitivity and specificity of assessment instruments of quality of life in rheumatoid arthritis
Conclusion: For evaluation of the physical aspects in patients with RA, the HAQ is the most accurate. For evaluation of emotional aspects the NHP is the most indicated, although the SF-36 was the only one in the evaluation of general domains.RESUMO Objetivo: Verificar a sensibilidade e a especificidade dos instrumentos de avalia ção da qualidade de vida em pacientes com artrite reumatoide (AR). Metodologia: Estudo de acurácia em uma amostra de pacientes com diagnóstico confirmado de AR. Aplicaram-se os questionários de QV SF-36 (padrão ouro), HAQ e NHP. Usaram-se o coeficiente de correlação de Pearson, a curva RO...
Source: Revista Brasileira de Reumatologia - October 25, 2016 Category: Rheumatology Source Type: research
The representation of getting ill in adolescents with systemic lupus erythematosus
Conclusions: Considering as subjective and dynamic the experience of getting ill, knowing the representations can contribute to the orientation of conduct and type of psychotherapeutic intervention needed.RESUMO Introdu ção: Esse estudo, feito em um hospital federal na cidade do Rio de Janeiro, teve por objetivo analisar a representação social da doença crônica e de seu tratamento, na perspectiva de adolescentes e de seus cuidadores. Métodos: A amostra consistiu de 31 adolescentes (11 – 21 anos) com l úpus eritematoso sistêmico e 19 cuidadores (32 – 66 anos), seguidos em servi ços pediátricos e de clínica...
Source: Revista Brasileira de Reumatologia - October 25, 2016 Category: Rheumatology Source Type: research
High frequency of asymptomatic hyperparathyroidism in patients with fibromyalgia: random association or misdiagnosis?
Conclusions: A high frequency of hyperparathyroidism was noted in women with FM versus the general population. Normocalcemic hyperparathyroidism was also more frequent in patients with FM. Longitudinal studies with greater number of patients are needed to assess w hether this is an association by chance only, if the increased serum levels of PTH are part of FM pathophysiology, or even if these would not be cases of FM, but of hyperparathyroidism.RESUMO A fibromialgia (FM) e o hiperparatireoidismo podem apresentar sintomas semelhantes (dores osteomusculares, dist úrbios cognitivos, insônia, depressão e ansiedade) e causa...
Source: Revista Brasileira de Reumatologia - October 25, 2016 Category: Rheumatology Source Type: research
A prospective study predicting the outcome of chronic low back pain and physical therapy: the role of fear-avoidance beliefs and extraspinal pain
Conclusion: We identified high FABQ-work and extraspinal pain scores as key determinants of a worse response to physical therapy among CLBP patients, supporting the need for a special rehabilitation program for this subgroup.RESUMO Objetivo: Identificar os fatores progn ósticos para a fisioterapia convencional em pacientes com lombalgia mecânica comum crônica (LMC). Métodos: Estudo prospectivo observacional. Participantes: Foram selecionados pelo Ambulatório de Doenças da Coluna Vertebral 113 pacientes com lombalgia mecânica comum crônica. Medidas de des fecho principais: A intensidade da dor foi pontuada utili...
Source: Revista Brasileira de Reumatologia - October 25, 2016 Category: Rheumatology Source Type: research
The European Portuguese adaptation of the Fear of Pain Questionnaire
ABSTRACT In Portugal, it is estimated that chronic pain affects 36.7% of the population, constituting a multifactorial phenomenon with great impact at individual, family, community, and social levels. In the fear-avoidance model of pain, one of the most consistent consensual in the literature, the fear arises as one of the variables that can contribute to the development and maintenance of this condition. Thus, instruments for evaluating the fear of pain, as Fear of Pain Questionnaire (FPQ-III), may be useful in the conceptualization of the subjective experience of pain. Accordingly, this paper aims to describe the adaptat...
Source: Revista Brasileira de Reumatologia - October 25, 2016 Category: Rheumatology Source Type: research
Cyclophosphamide administration routine in autoimmune rheumatic diseases: a review
Publication date: Available online 24 October 2016 Source:Revista Brasileira de Reumatologia (English Edition) Author(s): Kaian Amorim Teles, Patricia Medeiros-Souza, Francisco Aires Correa Lima, Bruno Gedeon de Araújo, Rodrigo Aires Correa Lima Cyclophosphamide is an alkylating agent widely used for the treatment of malignant neoplasia and which can be used in the treatment of multiple rheumatic diseases. Medication administration errors may lead to its reduced efficacy or increased drug toxicity. Many errors occur in the administration of injectable drugs. The present study aimed at structuring a routine for cycl...
Source: Revista Brasileira de Reumatologia - October 24, 2016 Category: Rheumatology Source Type: research
Polymorphisms in NAT2 (N-acetyltransferase 2) gene in patients with systemic lupus erythematosus
Publication date: Available online 25 October 2016 Source:Revista Brasileira de Reumatologia (English Edition) Author(s): Elaine Cristina Lima dos Santos, Amanda Chaves Pinto, Evandro Mendes Klumb, Jacyara Maria Brito Macedo Objective To investigate potential associations of four substitutions in NAT2 gene and of acetylator phenotype of NAT2 with systemic lupus erythematosus (SLE) and clinical phenotypes. Methods Molecular analysis of 481C>T, 590G>A, 857G>A, and 191G>A substitutions in the NAT2 gene was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-R...
Source: Revista Brasileira de Reumatologia - October 24, 2016 Category: Rheumatology Source Type: research
Fc gamma receptor IIIa polymorphism is not associated with susceptibility to systemic lupus erythematosus in Brazilian patients
Publication date: Available online 25 October 2016 Source:Revista Brasileira de Reumatologia (English Edition) Author(s): Marcelle Grecco, Viviane Cardoso dos Santos, Kaline Medeiros Costa Pereira, Luís Eduardo Coelho Andrade, Neusa Pereira da Silva We evaluated the possible association between FCGR3A V/F (158) polymorphism and SLE susceptibility and clinical phenotype in 305 sequentially retrieved SLE patients and 300 healthy controls from the southeastern part of Brazil by allele-specific polymerase chain reaction. Our results showed no association between FCGR3A 158V/F alleles and susceptibility to SLE in this s...
Source: Revista Brasileira de Reumatologia - October 24, 2016 Category: Rheumatology Source Type: research
Esophageal abnormalities in juvenile localized scleroderma: is it associated with other extracutaneous manifestations?
Conclusions Our study demonstrated that EI was frequently observed in JLS patients, mainly in asymptomatic patients with linear subtype. EI occurred in JLS patients with other extracutaneous manifestations and required methotrexate therapy. (Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - October 23, 2016 Category: Rheumatology Source Type: research
