Role of HIF-1α signaling pathway in osteoarthritis: a systematic review
Abstract Osteoarthritis (OA) is the most common form of arthritis and is frequently diagnosed and managed in primary care; it is characterized by loss of articular hyaline cartilage, which is a unique connective tissue that physiologically lacks blood vessels. Articular cartilage survives in a microenvironment devoid of oxygen, which is regulated by hypoxia inducible factor (HIF-1 α ). HIF-1 α is considered the main transcriptional regulator of cellular and developmental response to hypoxia. To date, the relevance of HIF-1 α in the assessment of cartilage has increased since its participation is essential in the homeo...
Source: Revista Brasileira de Reumatologia - May 4, 2017 Category: Rheumatology Source Type: research
Fixed-flexion knee radiography using a new positioning device produced highly repeatable measurements of joint space width: ELSA-Brasil Musculoskeletal Study (ELSA-Brasil MSK)
Conclusions: Despite the difficulty in achieving consistent radioanatomic alignment between subsequent radiographs in terms of IMD, the protocol produced highly repeatable JSW measurements when these were taken at midpoint and 10 mm from the medial extremity of the medial tibial plateau. Therefore, measurements of JSW at these locations can be considered adequate for the assessment of knee OA in ELSA-Brasil MSK.Resumo Objetivo: Descrever o desempenho de um protocolo radiogr áfico em flexão fixa sem fluoroscopia em incidência PA com um novo posicionador, desenvolvido para a avaliação da osteoartrite de joelho (OA) no ...
Source: Revista Brasileira de Reumatologia - May 4, 2017 Category: Rheumatology Source Type: research
Vascular endothelial growth factor G1612A (rs10434) gene polymorphism and neuropsychiatric manifestations in systemic lupus erythematosus patients
Conclusion: Polymorphism in the gene coding for VEGF may be associated with increased incidence of neuropsychiatric lupus in SLE patients.Resumo Objetivo: Investigar a rela ção entre o polimorfismo genético do fator de crescimento vascular endotelial (VEGF) em pacientes com lúpus eritematoso sistêmico (LES) e manifestações neuropsiquiátricas relacionadas com o lúpus. Pacientes e métodos: Foram recrutados 60 pacientes adultos com LES nos departamentos de Reum atologia e Neurologia de hospitais universitários do Cairo e classificados em dois grupos; grupo A: 30 pacientes com manifestações neuropsiquiátricas (...
Source: Revista Brasileira de Reumatologia - May 4, 2017 Category: Rheumatology Source Type: research
Translation and validation of Neck Bournemouth Questionnaire to Brazilian Portuguese
Conclusion: Neck Bournemouth Questionnaire was translated and culturally adapted to Portuguese language, and it demonstrated to be valid and reliable to evaluate patients ’ neck pain.Resumo Objetivo: Traduzir o Neck Bournemouth Questionnaire para o portugu ês do Brasil, adaptá-lo culturalmente e verificar a sua validade e confiabilidade. Métodos: O desenvolvimento da versão brasileira do Neck Bournemouth Questionnaire (NBQ-Brasil) foi baseado nas diretrizes propostas por Guillemin. O processo aplicado consistiu em tradução, retrotradução, rev isão por um comitê e pré-teste. Participaram deste estudo 61 volu...
Source: Revista Brasileira de Reumatologia - May 4, 2017 Category: Rheumatology Source Type: research
Analysis of sexual function of patients with dermatomyositis and polymyositis through self-administered questionnaires: a cross-sectional study
Conclusion s: This was the first study to identify sexual dysfunction in patients with DM/PM. Therefore, a multidisciplinary approach is essential for patients with idiopathic inflammatory myopathies, in order to provide prevention and care for their sexual life, providing a better quality of life, both for pa tients and their partners.Resumo Introdu ção: Até o presente momento, não há descrições na literatura da avaliação ginecológica e da função sexual em pacientes do sexo feminino com dermatomiosite (DM) e polimiosite (PM). Objetivos: Avaliar a função sexual em pacientes do sexo feminino com DM/PM. Casu...
Source: Revista Brasileira de Reumatologia - May 4, 2017 Category: Rheumatology Source Type: research
EpiFibro (Brazilian Fibromyalgia Registry): data on the ACR classification and diagnostic preliminary criteria fulfillment and the follow-up evaluation
Conclusion: InEpiFibro, most patients fulfill simultaneously the ACR1990 and ACR2010. A larger number of patients fulfill the ACR2010 at the time of the evaluation. There was a moderate correlation between the Polysymptomatic Distress Scale and the Fibromyalgia Impact Questionnaire. Most patients remained stable over time.Resumo Introdu ção: O EpiFibro (Estudo Epidemiológico Brasileiro de Fibromialgia) foi criado para estudar pacientes com fibromialgia. Foram incluídos pacientes desde 2011 de acordo com os critérios de classificação para a fibromialgia do American College of Rheumatology de 1990 (ACR1990). Objetiv...
Source: Revista Brasileira de Reumatologia - May 4, 2017 Category: Rheumatology Source Type: research
Has the median nerve involvement in rheumatoid arthritis been overemphasized?
Abstract Rheumatoid arthritis (RA) is a well and widely recognized cause of carpal tunnel syndrome (CTS). In the rheumatoid wrist, synovial expansion, joint erosions and ligamentous laxity result in compression of the median nerve due to increased intracarpal pressure. We evaluated the published studies to determine the prevalence of CTS and the characteristics of the median nerve in RA and its association with clinical parameters such as disease activity, disease duration and seropositivity. A total of 13 studies met the eligibility criteria. Pooled data from 8 studies with random selection of RA patients revealed that 86...
Source: Revista Brasileira de Reumatologia - May 4, 2017 Category: Rheumatology Source Type: research
Intra-articular injection with triamcinolone hexacetonide in patients with rheumatoid arthritis: prospective assessment of goniometry and joint inflammation parameters
Conclusion: VASSw responded better at short and medium term after IAI with triamcinolone hexacetonide in our sample of RA patients.Resumo Objetivos: Avaliar vari áveis articulares locais após a injeção intra-articular (IIA) de hexacetonido de triancinolona (HT) em pacientes com artrite reumatoide (AR). Métodos: Avaliaram-se de modo cego e prospectivo (inicial, 1, 4, 12 e 24 semanas) as articulações metacarpofalângica (MCF), punho, cotovelo, ombro, j oelho e tornozelo após a IIA de HT à procura das seguintes medidas de desfecho: escala visual analógica (EVA) de 0 a 10 cm para dor em repouso (EVAr); EVA para dor...
Source: Revista Brasileira de Reumatologia - May 4, 2017 Category: Rheumatology Source Type: research
Incidence and prevalence of systemic sclerosis in Campo Grande, State of Mato Grosso do Sul, Brazil
Conclusions: The city of Campo Grande, the state capital of MS, presented a lower incidence/prevalence of systemic sclerosis in comparison with those numbers found in US studies and close to European studies ’ data.Resumo Introdu ção: A esclerose sistêmica (ES) é uma enfermidade autoimune, extremamente heterogênea na sua apresentação clínica e segue um curso variável e imprevisível. Embora algumas discrepâncias nas taxas de incidência e prevalência entre regiões possam refletir as diferenças metodológicas na definição e verificação dos casos, elas também podem refletir as verdadeiras diferenças lo...
Source: Revista Brasileira de Reumatologia - May 4, 2017 Category: Rheumatology Source Type: research
Effects of the use of growth hormone in children and adolescents with juvenile idiopathic arthritis: a systematic review
Conclusion: The majority of studies reported positive effects after the therapeutic use of GH, but some variability in response to treatment was observed. The combination of growth hormone with other drugs seems to be a good option.Resumo Introdu ção: Crianças com artrite idiopática juvenil (AIJ) frequentemente apresentam prejuízo no crescimento e baixa estatura. Existem evidências de que o uso terapêutico do hormônio de crescimento (GH) é útil e seguro nesses pacientes. Objetivo: Analisar os efeitos do uso de GH em pacientes com AIJ. Método: Fez-se revisão sistemática da literatura nos últimos 18 anos, na...
Source: Revista Brasileira de Reumatologia - May 4, 2017 Category: Rheumatology Source Type: research
The effectiveness of Kinesio Taping on pain and disability in cervical myofascial pain syndrome
Conclusion: This study shows that Kinesio Taping leads to improvements on pain, pressure pain threshold and cervical range of motion, but not disability in short time. Therefore, Kinesio Taping can be used as an alternative therapy method in the treatment of patients with MPS.Resumo Objetivo Investigar a efic ácia do kinesio taping e do taping placebo sobre a dor, limiar de dor à pressão, amplitude de movimento cervical e incapacidade em pacientes com síndrome dolorosa miofascial (SDM) cervical. Métodos: Ensaio clínico randomizado duplo-cego controlado por placebo. Foram alocados em dois grupos, a leatoriamente, 61...
Source: Revista Brasileira de Reumatologia - May 4, 2017 Category: Rheumatology Source Type: research
Chronic low back pain in patients with systemic lupus erythematosus: prevalence and predictors of back muscle strength and its correlation with disability
Conclusions The prevalence of chronic low back pain in individuals with systemic lupus erythematosus was 26%. The maximal voluntary isometric contraction of the back muscles was 63% predicted by five variables of interest, however, only the handgrip strength was a statistically significant predictive variable. The maximal voluntary isometric contraction of the back muscles presented a linear relation directly proportional to handgrip and inversely proportional to Oswestry Index i.e. stronger back muscles are associated with lower disability scores. (Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - April 29, 2017 Category: Rheumatology Source Type: research
Role of HIF-1 α signaling pathway in osteoarthritis: a systematic review
Publication date: March–April 2017 Source:Revista Brasileira de Reumatologia (English Edition), Volume 57, Issue 2 Author(s): Javier Fernández-Torres, Gabriela Angélica Martínez-Nava, María Concepción Gutiérrez-Ruíz, Luis Enrique Gómez-Quiroz, Marwin Gutiérrez Osteoarthritis (OA) is the most common form of arthritis and is frequently diagnosed and managed in primary care; it is characterized by loss of articular hyaline cartilage, which is a unique connective tissue that physiologically lacks blood vessels. Articular cartilage survives in a microenvironment devoid of oxygen, which is regulated by hypoxia ...
Source: Revista Brasileira de Reumatologia - April 16, 2017 Category: Rheumatology Source Type: research
Relapsing polychondritis: prevalence of cardiovascular diseases and its risk factors, and general disease features according to gender
Publication date: Available online 15 March 2017 Source:Revista Brasileira de Reumatologia (English Edition) Author(s): Pablo Arturo Olivo Pallo, Maurício Levy-Neto, Rosa Maria Rodrigues Pereira, Samuel Katsuyuki Shinjo The comorbidities in relapsing polychondritis have been scarcely described in the literature. Moreover, apart from a few relapsing polychondritis epidemiological studies, no studies specifically addressing relapsing polychondritis distribution according to gender are available. Therefore, the objectives of the present study were: (a) to analyze the prevalence of cardiovascular diseases and its risk f...
Source: Revista Brasileira de Reumatologia - April 16, 2017 Category: Rheumatology Source Type: research
Pulmonary magnetic resonance imaging is similar to chest tomography in detecting inflammation in patients with systemic sclerosis
Publication date: Available online 18 March 2017 Source:Revista Brasileira de Reumatologia (English Edition) Author(s): Carolina de Souza Müller, Danny Warszawiak, Eduardo dos Santos Paiva, Dante Luiz Escuissato Interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH) are prevalent complications of systemic sclerosis (SSc) and are currently the leading causes of death related to the disease. The accurate recognition of these conditions is therefore of utmost importance for patient management. A study was carried out with 24 SSc patients being followed at the Rheumatology Department of the Hospital d...
Source: Revista Brasileira de Reumatologia - April 16, 2017 Category: Rheumatology Source Type: research
