Role of HIF-1α signaling pathway in osteoarthritis: a systematic review

Abstract Osteoarthritis (OA) is the most common form of arthritis and is frequently diagnosed and managed in primary care; it is characterized by loss of articular hyaline cartilage, which is a unique connective tissue that physiologically lacks blood vessels. Articular cartilage survives in a microenvironment devoid of oxygen, which is regulated by hypoxia inducible factor (HIF-1 α ). HIF-1 α is considered the main transcriptional regulator of cellular and developmental response to hypoxia. To date, the relevance of HIF-1 α in the assessment of cartilage has increased since its participation is essential in the homeostasis of this tissue. Taking into account the new emerging insights of HIF-1 α in the scientific literature in the last years, we focused the present review on the potential role of HIF-1 α signaling pathway in OA development, especially in how some genetic factors may influence the maintenance or breakdown of articular cartilage.Resumo A osteoartrite (OA) é a forma mais comum de artrite e frequentemente é diagnosticada e gerenciada na atenção primária; é caracterizada por perda da cartilagem articular hialina, um tecido conjuntivo único que fisiologicamente carece de vasos sanguíneos. A cartilagem articular sobrevive em um microambiente despr ovido de oxigênio, que é regulado pelo fator induzível por hipóxia-1 α (HIF-1 α ). O HIF-1 α é considerado o principal regulador transcricional da resposta celular e de desenvolvimento à hipóxia...
Source: Revista Brasileira de Reumatologia - Category: Rheumatology Source Type: research