Genetics of rheumatoid arthritis: a new boost is needed in Latin American populations
This article describes what is known about the RA genetics, the future that is emerging, and how this will develop a more personalized approach for the treatment of the disease. Latin American RA patients cannot be excluded from this final aim, and a higher collaboration with the international consortia may be needed for a better knowledge of the genetic profile of patients from this origin.RESUMO A artrite reumatoide (AR) é uma doença reumática inflamatória autoimune que afeta vários órgãos e tecidos, predominantemente as articulações sinoviais. Como muitas outras doenças autoimunes, a AR é uma doença complexa...
Source: Revista Brasileira de Reumatologia - May 3, 2016 Category: Rheumatology Source Type: research
Periodontitis and systemic lupus erythematosus
This study aims to review the literature about this potential association and their different pathogenic mechanisms. Considering that periodontal disease is a disease characterized by inflammation influenced by infectious factors, such as SLE, it is plausible to suggest that SLE would influence periodontal disease and vice-versa. However, this issue is not yet fully elucidated and several mechanisms have been proposed to explain this association, as deregulation mainly in innate immune system, with action of phagocytic cells and proinflammatory cytokines such as IL-1β and IL-18 in both conditions’ pathogenesis, leading ...
Source: Revista Brasileira de Reumatologia - May 3, 2016 Category: Rheumatology Source Type: research
Platelet-rich plasma for osteoarthritis treatment
ABSTRACT We conducted a comprehensive and systematic search of the literature on the use of platelet-rich plasma (PRP) in the treatment of osteoarthritis, using the Medline, Lilacs, Cochrane and SciELO databases, from May 2012 to October 2013. A total of 23 studies were selected, with nine being controlled trials and, of these, seven randomized, which included 725 patients. In this series, the group receiving PRP showed improvement in pain and joint function compared to placebo and hyaluronic acid. The response lasted up to two years and was better in milder cases. However it was found that there is no standardization in t...
Source: Revista Brasileira de Reumatologia - May 3, 2016 Category: Rheumatology Source Type: research
Brazilian multicenter study of 71 patients with juvenile-onset Takayasu's arteritis: clinical and angiographic features
Conclusion: This is the largest study on juvenile-onset Takayasu arteritis, and a high number of patients under the age of 10 years, with predominance of constitutional symptoms early in the disease, was observed.RESUMO Objetivo: Descrever as caracterÃsticas clÃnicas e angiográficas da arterite de Takayasu em crianças e adolescentes brasileiros. Métodos: Foi feita coleta retrospectiva de dados de 71 crianças e adolescentes acompanhados em 10 centros brasileiros de referência em reumatologia pediátrica. A avaliação foi feita em três tempos: inÃcio dos sintomas até o diagnóstico, do 6º ao 12º mês de diagnÃ...
Source: Revista Brasileira de Reumatologia - May 3, 2016 Category: Rheumatology Source Type: research
Assessment of cardiovascular risk in patients with rheumatoid arthritis using the SCORE risk index
Conclusion: The SCORE risk index is similar in both groups, but with the application of the mSCORE index, we recognized that RA patients have a higher 10-year risk of a fatal cardiovascular disease event, and this reinforces the importance of factors inherent to the disease not measured in the SCORE risk index, but considered in mSCORE risk index.RESUMO Introdução: Artrite reumatoide (AR) é uma doença autoimune que determina manifestações sistêmicas e está associada a aumento do risco de evento cardiovascular. Objetivo: Analisar o Ãndice SCORE de predição de evento cardiovascular em pacientes do gênero femini...
Source: Revista Brasileira de Reumatologia - May 3, 2016 Category: Rheumatology Source Type: research
Indirect and direct costs of treating patients with ankylosing spondylitis in the Brazilian public health system
Conclusions: The Brazilian public health system's spending related to ankylosing spondylitis has increased in recent years. An important part of these costs is due to the introduction of new, more expensive health technologies, as in the case of nuclear magnetic resonance and, mainly, the incorporation of anti-TNF therapy into the therapeutic arsenal. The mean annual direct and indirect cost to the Brazilian public health system to treat a patient with ankylosing spondylitis, according to our findings, is US$ 23,183.56.RESUMO Introdução: Os pacientes com espondilite anquilosante (EA) exigem uma abordagem de equipe com v...
Source: Revista Brasileira de Reumatologia - May 3, 2016 Category: Rheumatology Source Type: research
Comparative study of functional capacity and quality of life among obese and non-obese elderly people with knee osteoarthritis
Conclusion: OA associated with obesity caused a negative impact on functional capacity; however, quality of life scores were low, and no difference in obese and non-obese subjects was found.RESUMO Introdução: A associação entre osteoartrite (OA) e obesidade pode gerar redução da capacidade funcional e comprometer a qualidade de vida (QV) de idosos.Objetivo Comparar a capacidade funcional e a QV entre idosos com OA no joelho, obesos e não obesos.A amostra foi constituÃda por 35 idosos com OA divididos em dois grupos, obesos e não obesos, de acordo com o Ãndice de massa corporal. Para avaliação da capacidade fun...
Source: Revista Brasileira de Reumatologia - May 3, 2016 Category: Rheumatology Source Type: research
Metabolic syndrome in patients with rheumatoid arthritis followed at a University Hospital in Northeastern Brazil
Conclusions: RA patients in a tertiary center in Northeastern Brazil showed high prevalence of MS. It is worth noting that almost all patients had MS and abdominal obesity, which has important practical implications. In addition to the components of MS, age and smoking were associated with this syndrome.RESUMO Introdução: Pacientes com artrite reumatoide (AR) têm 30 a 60% mais chances de desenvolver doenças cardiovasculares (DCV) do que a população geral. A sÃndrome metabólica (SM), definida por um conjunto de fatores de risco cardiovasculares, confere maior risco de DCV e diabete. A associação da SM com AR aind...
Source: Revista Brasileira de Reumatologia - May 3, 2016 Category: Rheumatology Source Type: research
Osteoporosis in primary care: an opportunity to approach risk factors
Conclusion: The patients followed the socioeconomic and demographic profile of Maranhão. Most had menarche and menopause in appropriate periods, showed no positive family history of osteoporosis, did not usually drink alcohol, were sedentary and the caffeine intake was high.RESUMO Introdução: As mulheres no climatério estão suscetÃveis a uma série de mudanças, entre elas a osteoporose. A osteoporose é uma doença caracterizada por uma baixa massa óssea e susceptibilidade à fratura. Atualmente, essa doença é um problema de saúde pública e é necessário reconhecer seus fatores de risco. Objetivos: Identific...
Source: Revista Brasileira de Reumatologia - May 3, 2016 Category: Rheumatology Source Type: research
Food intake assessment and quality of life in women with fibromyalgia
Conclusion: Women with FM showed a lower qualitatively and quantitatively intake in comparison with CT group. Only vitamin E correlated with quality of life and percentage of protein in the diet with sensation of pain.RESUMO Comparar a ingestão alimentar de mulheres com e sem fibromialgia e verificar se a ingestão alimentar das pacientes com fibromialgia interfere na sensação de dor e qualidade de vida.Participaram do estudo mulheres com fibromialgia (FM) atendidas no Ambulatório de Fibromialgia do Hospital de ClÃnicas/UFPR e para o grupo controle (CT) foram convidadas mulheres saudáveis. A coleta de dados foi feita...
Source: Revista Brasileira de Reumatologia - May 3, 2016 Category: Rheumatology Source Type: research
Retroperitoneal fibrosis: case series of five patients and review of the literature
ABSTRACT Chronic periaortitis (CP) is an umbrella term used to describe a group of nosologically allied conditions that include idiopathic retroperitoneal fibrosis (Ormond's disease), inflammatory abdominal aortic aneurysm, and perianeurysmal retroperitoneal fibrosis. Retroperitoneal fibrosis encompasses a range of diseases characterized by the presence of a fibro-inflammatory tissue, which usually surrounds the abdominal aorta and the iliac arteries and extends into the retroperitoneum to envelop neighboring structures-ureters. Retroperitoneal fibrosis is generally idiopathic, but can also be secondary to the use of certa...
Source: Revista Brasileira de Reumatologia - May 3, 2016 Category: Rheumatology Source Type: research
Electrocardiographic changes in dermatomyositis and polymyositis
Conclusions: We showed distinct ECG changes between DM and PM and a higher frequency of LVH in patients compared to controls. Investigation of cardiac involvement should be considered even in asymptomatic patients, especially PM. Further studies are necessary in order to determine the correlation of ECG findings with other complementary tests, clinical manifestations, disease activity and progression to other cardiac diseases.RESUMO Introdução: Acometimento cardÃaco nas miopatias inflamatórias é frequente. Eletrocardiograma (ECG) pode mostrar indÃcios desse acometimento e suas alterações devem ser bem conhecidas e...
Source: Revista Brasileira de Reumatologia - May 3, 2016 Category: Rheumatology Source Type: research
Rheumatoid arthritis and metabolic syndrome
(Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - May 3, 2016 Category: Rheumatology Source Type: research
Development of rheumatology training in Brazil: the option for a medical residency program
Conclusions In the last sixteen years, in parallel with the expansion of places of access, MRPR has established itself as the preferred route for rheumatology training in Brazil, mainly supported by public funds. Regional inequalities in the provision of MRPR positions still persist, as challenges that must be faced. (Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - April 29, 2016 Category: Rheumatology Source Type: research
Association between academic performance and cognitive dysfunction in patients with juvenile systemic lupus erythematosus
Conclusion Patients with JSLE concomitantly with cognitive dysfunction showed worse academic performance in mathematics compared to patients without cognitive impairment. (Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - April 18, 2016 Category: Rheumatology Source Type: research
