Pumpkin seeds, Centella asiatica, Boswellia, Helichrysum, acetate vitamin E, Melaleuca alternifolia and hyaluronic acid phytocomplex monotherapy effects in patients with chronic pelvic pain syndrome.
CONCLUSIONS: Proxelan® monotherapy may represents a promising valid alternative to combined treatment with antibiotics in patients with CP/CPPS symptoms although the results obtained should be investigated in randomized controlled trials. PMID: 31558010 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - September 28, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Robotic partial nephrectomy versus radical nephrectomy in elderly patients with large renal masses.
CONCLUSIONS: RPN In elderly patientswith large renal masses provides RPN offers acceptable surgical, and oncological outcomes allowing better functional preservation relative to RRN. The decision to undergo RPN in this subset of patients should be tailored on a case by case basis. PMID: 31527571 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - September 20, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Clinical implications of prostatic capsular abutment or bulging on multiparametric magnetic resonance imaging.
CONCLUSIONS: The PIRADS v2 scoring system has a grey zone concerning ECE as defined by capsule abutment or bulging. We found an increased risk of ECE and specifically focal ECE when capsule bulging or abutment on mpMRI are documented. PMID: 31524202 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - September 17, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Multimodal treatment in Focal Therapy for localized prostate cancer using concomitant short-term androgen deprivation therapy: the ENHANCE prospective pilot study.
Authors: Marra G, Dell'oglio P, Baghdadi M, Cathelineau X, Sanchez-Salas R, EvaluatioN of HIFU Hemiablation and short term AndrogeN deprivation therapy Combination to Enhance prostate cancer control (ENHANCE) study investigators Abstract FT for localized PCa is emerging to reduce adverse effects of radical treatments, while maintaining comparable oncological outcomes. However, an area for improvement still exists and a gap in cancer control needs to be filled by complementing the with additional forms of treatment to minimize failures. Part of the recurrences/persistences after FT may be related to PCa mic...
Source: Minerva Urologica e Nefrologica - September 13, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

3D mixed reality holograms for preoperative surgical planning of nephron-sparing surgery: evaluation of surgeons' perception.
CONCLUSIONS: Our study suggests that surgeons perceive holograms and MR as a useful and interesting tool for the preoperative setting before partial nephrectomy, in the direction of an ever more precise surgery. PMID: 31486325 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - September 7, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Prostate cancer management at an Italian tertiary referral centre: does multidisciplinary team meeting influence diagnostic and therapeutic decision-making process? A snapshot of the everyday clinical practice.
CONCLUSIONS: The uro-oncology MDT meeting alters management plans in at least one-quarter of patients reaching almost 50% of cases in locally advanced disease. PMID: 31487974 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - September 7, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Real-life data on long-term follow-up of patients successfully treated with percutaneous tibial nerve stimulation (PTNS).
CONCLUSIONS: Despite some limitations, this study shows that the majority of patients who responded to PTNS considered themselves still improved at a seven- year follow-up. Larger studies are needed to confirm our results, but our study has the novel advantage of showing data derived from "real life" over the longest follow- up yet considered in the literature. PMID: 31487975 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - September 7, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Assessment of local tumor ablation and non-interventional management versus partial nephrectomy in T1a renal cell carcinoma.
CONCLUSIONS: In T1a RCC patients, NIM rates showed a modest but significant increase, while LTA and PN rates remained stable. In survival analyses, LTA exhibited higher CSM rates only for elderly patients. Conversely, NIM exhibited higher CSM rates in both younger and older patients. PMID: 31487976 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - September 7, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Anterograde ejaculation preservation after endoscopic treatments in patients with bladder outlet obstruction: systematic review and pooled-analysis of randomized clinical trials.
CONCLUSIONS: Data reporting anterograde ejaculation preservation after endoscopic treatment in patients with BPE are sparse and heterogeneous. Pooled analyses suggest that new technological alternatives to conventional TURP might improve sexual outcomes, especially for non-ablative treatments. PMID: 31487977 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - September 7, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Is there any benefit in adding postoperative adjuvant concurrent radiotherapy and chemotherapy for penile cancer with regional lymph node metastasis?
CONCLUSIONS: Penile cancer with extensive RLNM carries a poor prognosis. Despite having more extensive RLNM, the RT-CHT group had a similar overall survival as the Surveillance Group. This suggests a potential benefit of postoperative adjuvant concurrent RT-CHT for patients with extensive RLNM, although it carries an increased risk of complications. Further study is warranted to assess the benefit-to-risk ratio of this combined adjuvant therapy. PMID: 31353875 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - July 31, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Bone-targeted therapy in castration-resistant prostate cancer: where do we stand?
CONCLUSIONS: Reducing skeletal-related morbidity remains a crucial goal of palliative life-extending therapy in mCRPC. New data about dosing schedules and combinations of different treatments will continue to refine the optimal strategy for incorporating BTAs into the new treatment paradigms for PCa. Novel molecules such as PSMA-targeted small molecules promise theranostic agents in the management of PCa patients. PMID: 31353876 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - July 31, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Liver transplantation techniques avoid extracorporeal circulation in the treatment of renal cell carcinoma with cavo-atrial tumor thrombi: a contemporary experience.
Authors: Selli C, Baldesi R, Manassero F, Mogorovich A, Galli L, Roffi N, Urban L Abstract PMID: 31287253 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - July 11, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Total anatomical reconstruction during robot-assisted radical prostatectomy in patients with previous prostate surgery: perioperative, oncologic and medium-term functional outcomes in a single surgeon's series.
CONCLUSIONS: In our experience patients with prostate cancer and a previous surgery for BPH should be managed as naïve patients. RARP is a safe and feasible procedure with no major risks of complications, provided that it is performed by a skilled robotic surgeon. PMID: 31287254 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - July 11, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

The visual percutaneous nephrolithotomy versus the conventional percutaneous nephrolithotomy in treatment for renal stone.
CONCLUSIONS: We found that visual PCNL was a safe and efficacious treatment for renal stones that may be considered as an alternative to conventional PCNL, especially in patients with mild hydronephrosis. Further prospective randomized controlled trials are needed to confirm the results of this study . PMID: 31287255 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - July 11, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Partial nephrectomy versus radical nephrectomy for cT2 or greater renal tumors: a systematic review and meta-analysis.
CONCLUSIONS: PN shows a feasible, safe and viable treatment option for larger renal tumors because it provides better preservation of kidney function and non-inferior survival. However, PN in patients with stage T2 or greater renal masses should be more selective, because of higher complications. PMID: 31287256 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - July 11, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research