Myomectomy: technique and current indications.
Authors: Rakotomahenina H, Rajaonarison J, Wong L, Brun JL
Abstract
BACKGROUND: Uterine fibroids are the commonest benign tumor of the female genital tract. They affect a significant proportion of reproductive aged women and may cause excessive menstrual bleeding, pelvic pain or pressure, and adversely affect reproductive outcomes. However, many women remain asymptomatic. Fibroids are the first indication for hysterectomy, but myomectomy is the most suitable surgical option for women who desire preservation of their fertility potential. Only a selected group of women of childbearing age will benefit from a...
Source: Minerva Ginecologica - April 28, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Efficacy and tolerability of a plant-based, multi-component cream (Ginetrox ®) in vulvovaginal disorders of the genitourinary syndrome during menopause.
CONCLUSIONS: This preliminary study suggests that the plant-based, multi-component cream Ginetrox® could be effective and safe in counteracting menopause-related vaginal discomfort symptoms.
PMID: 28420227 [PubMed - in process] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - April 21, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Outcome of endometrial cancer after lymphadenectomy, a single center retrospective analysis of 829 cases with long-lasting follow-up.
CONCLUSIONS: Lymphadenectomy plays a role in preventing relapses but it is not proved that non-aggressive lymphadenectomy in endometrial cancer improves overall survival at p level of 0.05. Therefore, it cannot be excluded that a very small improvement in long lasting survival in few cases of endometrial cancer could be due to node dissections.
PMID: 28398020 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - April 13, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research
The role of seminal fluid in infertility.
Authors: Bonnic J, Fenech A, Muscat C, Calleja-Agius J
Abstract
Approximately 15 % of couples worldwide are considered infertile, with up to 50 % due to a defect in the male reproductive physiology. Many of these latter defects are idiopathic or genetically related and mostly focused on the spermatozoon and as such, the majority of studies to date have focused mainly on disorders related with the sperm cell. In this review, the importance of seminal fluid integrity and its effect on the female reproductive physiology is described in the context of male infertility. Human seminal plasma contains a vast arra...
Source: Minerva Ginecologica - April 13, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Teratology of valproic acid: an updated review of the possible mediating mechanisms.
Authors: Ponzano A, Tiboni GM
Abstract
Valproic acid (VPA) is an anti-epileptic drug (AED) which is currently being investigated for its potential application in the treatment of several types of cancers, including solid and non-solid tumor. It is well known that prenatal exposure to VPA largely increases the risk for malformations and other developmental disorders. This review concentrates on clinical and experimental data on congenital anomalies attributed to maternal VPA exposure during. Particular emphasis is paid to the potential mechanisms underlying VPA-induced malformations. Although several mechan...
Source: Minerva Ginecologica - April 13, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Clinical profile of women with VVA who are not candidates for local vaginal oestrogen therapy.
Authors: Nappi RE, Murina F, Perrone G, Villa P, Biglia N
Abstract
Vulvar and vaginal atrophy (VVA) is a chronic medical condition in postmenopausal women, which is predominantly due to a permanent cessation of ovarian oestrogen production. Current available treatment options for VVA are over-the-counter (OTC) symptomatic relief products or local oestrogen therapy (LET) aiming to treat this underlying atrophic condition. Recent surveys indicated that these products decrease sexual spontaneity, are messy and indiscrete. Ospemifene is an oral daily drug, which has proven to treat vaginal dryness and dyspareu...
Source: Minerva Ginecologica - April 13, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Gonadotropin-releasing hormone analogues for the prevention of chemotherapy-induced premature ovarian failure in breast cancer patients.
Authors: Conte B, Del Mastro L
Abstract
Since the survival of patients with cancer has significantly improved, chemotherapy-related premature ovarian failure (POF) in young cancer survivors has become a major issue in oncology. POF is associated with several health-related negative consequences, including menopausal symptoms, increased risk of cardiovascular diseases, osteoporosis, sexual disfunction, and infertility1-5. According to the major international guidelines, embryo/oocyte cryopreservation are the standard procedures for fertility preservation in young cancer women6,7. However, these techniques d...
Source: Minerva Ginecologica - April 13, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Sexual pain in women: quality of sex life and marital relations.
Authors: Ghizzani A, Orlandini C, Bernardi MG, Cevenini G, Luisi S
Abstract
Common gynecological and dermatological conditions resulting in sexual pain are seen often in gynecological practice and are easily diagnosed with visual observation and laboratory tests. The lower genital tract diseases we are referring to are: vaginitis, vaginoses, dermatoses, hypoestrogenism and endometriosis. All of them affect the vaginal mucosa with diverse mechanisms, their effects lasting for only few days or many months. Furthermore, they change the women's sense of well being sometimes significantly and for a long period....
Source: Minerva Ginecologica - April 8, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Complications of colorectal resection for endometriosis. Review.
Authors: Bouaziz J, Soriano D
Abstract
Based on a review of the current literature, we will discuss early and late (more than 3 months postoperative) complications associated with surgery for colorectal endometriosis resection. The most common surgical complications are: rectovaginal fistulae, anastomotic leakages and abscesses. Post-operative bleeding occurs rarely but has also been reported; and usually requires blood transfusion without surgical interventions. The selection of patients for surgery requires a multidisciplinary approach and complete preoperative imaging work-up by an experienced physician...
Source: Minerva Ginecologica - April 8, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Bladder endometriosis: a summary of current evidence.
Authors: Saccardi C, Vitagliano A, Litta P
Abstract
Bladder endometriosis is a specific form of endometriosis characterized by the presence of endometrial glands and stroma in the detrusor muscle. Such disease may involve different sites of the bladder, most frequently the base and the dome, with various grade of infiltration. Bladder nodules typically coexists with other localizations of deep pelvic endometriosis, resulting in a wide variety of abdominal and urinary symptoms that may be overlooked by clinicians. In spite of advances in understanding the genetic and molecular development of endometriosis, ...
Source: Minerva Ginecologica - April 8, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Genetic determinants of low birth weight.
Authors: Mallia T, Grech A, Hili A, Calleja Agius J, Pace NP
Abstract
Birth weight depends on the elaborate interaction between maternal and foetal genotypes, placental function, maternal nutrition and lifestyle and their effect on epigenetic regulators ofgene activity. The maternal environment in which the foetus develops is a critical factor indetermining birth weight. This review provides an overview of the effect of several geneticvariants leading to intrauterine growth restriction and low birth weight. Irrespective of theexact cause of genetic variations of foetal genes, intrauterine growth restrictio...
Source: Minerva Ginecologica - March 24, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Current evidence and emerging drug therapies for overactive bladder.
Authors: Izett M, Zacche M, Thiagamoorthy G, Robinson D, Cardozo L
Abstract
Overactive bladder is a common symptom complex with health related quality of life impacts on the individual as well as utilising health resources. Antimuscarinic therapy has been the mainstay of treatment and is well supported within the literature and guidelines. However, compliance is poor due to lack of efficacy and adverse events leading to the development of novel therapies. Mirabegron, the B3-adrenoreceptor agonist has emerged as an evidence-based alternative first or second line therapy. Two decades after its first clinical...
Source: Minerva Ginecologica - March 17, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Contraception for women with heart disease: an update.
Authors: Bonassi Machado R, Gandolpho AC, Santana N, Bocardo RC, Palandri N, Morassutti Machado R
Abstract
There is a lack of studies dealing specifically with contraceptive use in women with heart disease. This may generate doubts in professionals counseling on the patient's risk of pregnancy as a function of her cardiomyopathy. Moreover, uncertainties may arise with respect to the optimal contraceptive choice for each individual case. In view of the increasing number of women of reproductive age with cardiac disease, this review aims at providing practical guidance for clinicians, including cardiolo- gis...
Source: Minerva Ginecologica - March 10, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Ovarian cancer in endometriosis. Clinical and molecular aspects: an update.
Authors: Ruderman R, Pavone ME
Abstract
While endometriosis is a benign condition, the presence of endometriosis has been associated with the development of several types of cancers, including ovarian. Endometriomas, or ovarian endometriotic cysts, are found in 17-44% of patients with endometriosis, and may be a common precursor lesions to ovarian cancer. Endometriosis associated ovarian cancer is especially prominent in endometrioid and clear cell ovarian tumor histological subtypes. Several common pathways linking endometriosis and ovarian cancer have been elucidated, including the dominance of certain c...
Source: Minerva Ginecologica - March 10, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Individualization of controlled ovarian stimulation in IVF using ovarian reserve markers.
CONCLUSIONS: In this review we discuss how to choose the best COS therapy for the single patient, on the basis of the markers-guided ovarian response prediction.
PMID: 28271699 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - March 10, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research
